RECRUITING

Digital Accessible Remote Olfactory Mediated Health Assessments for Preclinical AD

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The goal of this study is to objectively test one's sense of smell, called olfaction, in participants with Subjective Cognitive Concerns (SCC), Mild Cognitive Impairment, Mild Behavioral Impairment (MBI), and age-matched controls. The main question it aims to answer is whether the AROMHA Brain Health Test could serve as a predictive biomarker of neurodegenerative disorders. This understanding will aid in the development of a noninvasive, cost-effective diagnostic tool that reliably and specifically distinguishes disease and normal aging populations. Participants will take the approximately 45-minute AROMHA Brain Health Smell Test where they will peel and sniff labels on the physical smell cards and answer questions on the web-based app relating to what they smelled. Participants will undergo tests for odor intensity, odor identification, odor discrimination, and episodic olfactory memory, but will not be provided the results of these tests.

Official Title

Digital Accessible Remote Olfactory Mediated Health Assessments for Preclinical AD

Quick Facts

Study Start:2023-05-09
Study Completion:2025-05
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT05881239

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 100 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * A clinical or research consensus diagnosis of the patient's condition or control status.
  2. * Individuals that are at least 18 years of age at the time of enrollment.
  3. * Individuals that are no older than 100 years of age at the time of enrollment.
  1. * Primary pulmonary disease such as severe emphysema or asthma not under good medical control.
  2. * Current sinusitis, common cold, upper respiratory infection, or nasal polyps.
  3. * Current or recent (past 6 months) alcohol or substance dependence. A prior history of alcohol or substance abuse will not be grounds for exclusion.
  4. * Pregnancy.
  5. * Severe cognitive dysfunction that would preclude completion of the olfactory testing.
  6. * An adverse reaction to fragrances (ie. they trigger a severe asthmatic attack or nausea).

Contacts and Locations

Study Contact

Mark W Albers, MD PhD
CONTACT
617-724-7401
albers.mark@mgh.harvard.edu
Alefiya Albers, PhD
CONTACT
AALBERS@mgh.harvard.edu

Principal Investigator

Mark W Albers, MD PhD
PRINCIPAL_INVESTIGATOR
Massachusetts General Hospital

Study Locations (Sites)

Massachusetts General Hospital
Boston, Massachusetts, 02129
United States

Collaborators and Investigators

Sponsor: Massachusetts General Hospital

  • Mark W Albers, MD PhD, PRINCIPAL_INVESTIGATOR, Massachusetts General Hospital

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2023-05-09
Study Completion Date2025-05

Study Record Updates

Study Start Date2023-05-09
Study Completion Date2025-05

Terms related to this study

Keywords Provided by Researchers

  • Alzheimer's disease
  • Olfactory
  • Neurodegeneration
  • Mild Cognitive Impairment
  • Mild Behavioral Impairment
  • Subjective Cognitive Concerns
  • Olfactory dysfunction
  • Biomarker
  • Cognitive Assessment

Additional Relevant MeSH Terms

  • Subjective Cognitive Concerns
  • Mild Cognitive Impairment
  • Mild Behavioral Impairment
  • Healthy Aging