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Individual Closed-Loop Neuromodulation Therapy for Alzheimer's Disease

Description

The project is a placebo-controlled study that aims to use closed-loop transcranial alternating current stimulation (tACS) to study patients with symptoms of mild cognitive impairment which is likely due to Alzheimer's disease or another form of dementia (AD-MCI). Patients will undergo an EEG and complete some questionnaires and computer tasks during each study visit. The project has the following aims and hypotheses: 1.) To determine the impact of closed-loop 40 Hz tACS on the entrainment of natural gamma rhythms in patients with AD-MCI, 2.) To determine the impact of closed-loop 40 Hz tACS on cognitive performance in patients with AD-MCI, and 3.) To assess the relationship between baseline neurodegenerative burden and impact of tACS. \[exploratory\]

Conditions

Alzheimer DiseaseMild Cognitive Impairment
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Related Conditions:

Alzheimer DiseaseMild Cognitive Impairment

Study Overview

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Study Details

Study overview

The project is a placebo-controlled study that aims to use closed-loop transcranial alternating current stimulation (tACS) to study patients with symptoms of mild cognitive impairment which is likely due to Alzheimer's disease or another form of dementia (AD-MCI). Patients will undergo an EEG and complete some questionnaires and computer tasks during each study visit. The project has the following aims and hypotheses: 1.) To determine the impact of closed-loop 40 Hz tACS on the entrainment of natural gamma rhythms in patients with AD-MCI, 2.) To determine the impact of closed-loop 40 Hz tACS on cognitive performance in patients with AD-MCI, and 3.) To assess the relationship between baseline neurodegenerative burden and impact of tACS. \[exploratory\]

Individual Closed-Loop Neuromodulation Therapy for Alzheimer's Disease

Individual Closed-Loop Neuromodulation Therapy for Alzheimer's Disease

Condition
Alzheimer Disease
Intervention / Treatment

-

Contacts and Locations

Charlestown

Massachusetts General Hospital, Charlestown, Massachusetts, United States, 02129

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Overall cognitive functional status consistent with amnesic MCI (CDR 0.5) likely due to AD (AD biomarker supported)
  • * 50-80 years of age
  • * English native speakers
  • * Known presence of a structural brain lesion (e.g., tumor, cortical infarct)
  • * Acute or decompensated active medical conditions, including cancer, cardiovascular disease, stroke, congestive heart failure
  • * Active hematological, renal, pulmonary, endocrine or hepatic disorders
  • * Longstanding premorbid history (i.e., longer than 10 years) of alcohol or substance abuse with continuous abuse up to and including the time that the symptoms leading to clinical presentation developed
  • * tACS contraindications (lesions in the scalp, history of seizures)

Ages Eligible for Study

50 Years to 80 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Massachusetts General Hospital,

Joan Camprodon, MD, PhD, MPH, PRINCIPAL_INVESTIGATOR, MGH, Division of Neuropsychiatry and Neuromodulation

Study Record Dates

2026-06