RECRUITING

Postextubation Use of Noninvasive Respiratory Support in Severely Obese Patients

Description

Around 20% of the obese patients with higher body mass index (BMI) who are taken off the breathing tube and breathing machine (ventilator) end up needing it back to support breathing. The re-application of breathing tube is associated with poor outcomes, including high risk of pneumonia, longer hospital stays, and death. The purpose of this study is to assess if prophylactic use of noninvasive breathing support after removing the breathing tube lowers the chance of needing the breathing tube again.

Conditions

Obesity, MorbidExtubation Failure
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Related Conditions:

Obesity, MorbidExtubation Failure

Study Overview

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Study Details

Study overview

Around 20% of the obese patients with higher body mass index (BMI) who are taken off the breathing tube and breathing machine (ventilator) end up needing it back to support breathing. The re-application of breathing tube is associated with poor outcomes, including high risk of pneumonia, longer hospital stays, and death. The purpose of this study is to assess if prophylactic use of noninvasive breathing support after removing the breathing tube lowers the chance of needing the breathing tube again.

A Randomized Controlled Trial of Postextubation Use of Noninvasive Respiratory Support in Severely Obese Patients

Postextubation Use of Noninvasive Respiratory Support in Severely Obese Patients

Condition
Obesity, Morbid
Intervention / Treatment

-

Contacts and Locations

Chicago

Rush University Medical Center, Chicago, Illinois, United States, 60612

Milwaukee

Medical College of Wisconsin, Milwaukee, Wisconsin, United States, 53226

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • 1. Adult, age ≥ 18 years old
  • 2. Receiving invasive mechanical ventilation for ≥24 hours
  • 3. BMI ≥40 kg/m2
  • 4. Undergoing planned extubation per treating team
  • 5. Arterial pH ≥7.35 or venous pH ≥ 7.31 within 30 mins of spontaneous breathing trial (SBT)
  • 1. Pregnant
  • 2. Use of extra-corporeal membrane oxygenation
  • 3. Chronic tracheostomy in place
  • 4. Unplanned or accidental extubation
  • 5. Terminal/compassionate extubation
  • 6. Contraindication to NIV use
  • 7. Intubated for neurological reasons or for airway protection (stroke, intracerebral hemorrhage, intraventricular hemorrhage)
  • 8. Intubated because of an acute exacerbation of COPD
  • 9. Underlying neuromuscular disease
  • 10. No reintubation requested by patient/family
  • 11. Documented/known history of chronic hypercapnic respiratory failure on home NIV (including bilevel PAP).
  • 12. Enrolled in any other outcome study
  • 13. Treating clinician feels that HFNC or NIV are either mandatory or contraindicated for a given patient

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Rush University Medical Center,

Ramandeep Kaur, PhD, PRINCIPAL_INVESTIGATOR, Rush University Medical Center

Babak Mokhlesi, MD, PRINCIPAL_INVESTIGATOR, Rush University Medical Center

Study Record Dates

2026-12-01