RECRUITING

The Prostate Cancer, Genetic Risk, and Equitable Screening Study (ProGRESS)

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

Prostate cancer is the most common non-skin cancer among Veterans and the second leading cause of male cancer death. Current methods of screening men for prostate cancer are inaccurate and cannot identify which men do not have prostate cancer or have low-grade cases that will not cause harm and which men have significant prostate cancer needing treatment. False-positive screening tests can result in unnecessary prostate biopsies for men who do not need them. However, new genetic testing might help identify which men are at highest risk for prostate cancer. This study will examine whether a genetic test helps identify men at risk for significant prostate cancer while helping men who are at low risk for prostate cancer avoid unnecessary biopsies. If this genetic test proves beneficial, it will improve the way that healthcare providers screen male Veterans for prostate cancer.

Official Title

The Prostate Cancer, Genetic Risk, and Equitable Screening Study (ProGRESS): A Pragmatic Trial of Precision Prostate Cancer Screening

Quick Facts

Study Start:2024-02-01
Study Completion:2030-09-30
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT05926102

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:55 Years to 69 Years
Sexes Eligible for Study:MALE
Accepts Healthy Volunteers:Yes
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * baseline age 55-69 years
  2. * receipt of regular VA care
  3. * Veteran status
  1. * personal history of prostate cancer
  2. * prior prostate biopsy, prostatectomy, or prostate MRI
  3. * known carrier status of rare variant associated with cancer syndrome

Contacts and Locations

Study Contact

Charles A Brunette, PhD
CONTACT
(857) 364-6324
charles.brunette@va.gov

Principal Investigator

Jason L Vassy, MD MPH
PRINCIPAL_INVESTIGATOR
VA Boston Healthcare System Jamaica Plain Campus, Jamaica Plain, MA

Study Locations (Sites)

VA Boston Healthcare System Jamaica Plain Campus, Jamaica Plain, MA
Boston, Massachusetts, 02130-4817
United States

Collaborators and Investigators

Sponsor: VA Office of Research and Development

  • Jason L Vassy, MD MPH, PRINCIPAL_INVESTIGATOR, VA Boston Healthcare System Jamaica Plain Campus, Jamaica Plain, MA

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2024-02-01
Study Completion Date2030-09-30

Study Record Updates

Study Start Date2024-02-01
Study Completion Date2030-09-30

Terms related to this study

Keywords Provided by Researchers

  • early detection of cancer
  • prostatic neoplasms
  • polygenic risk scores
  • family health history

Additional Relevant MeSH Terms

  • Prostate Cancer