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Treatment of Cognitive Deficits in Multiple Sclerosis With High-Definition Transcranial Direct Current Stimulation

Description

The purpose of the study is to test whether low level electric stimulation, called transcranial Direct Current Stimulation (tDCS), on the part of the brain (i.e., presupplementary motor area) thought to aid in memory will improve verbal retrieval in multiple sclerosis patients. The primary outcome measures are neuropsychological assessments of verbal retrieval, and the secondary measures are neuropsychological assessments of other cognitive abilities and electroencephalography (EEG) measures. Additionally, the study will examine the degree to which baseline assessments of cognition and concussion history predict responses to treatment over time, both on assessments administered within the intervention period and at follow-up.

Study Overview

Study Details

Study overview

The purpose of the study is to test whether low level electric stimulation, called transcranial Direct Current Stimulation (tDCS), on the part of the brain (i.e., presupplementary motor area) thought to aid in memory will improve verbal retrieval in multiple sclerosis patients. The primary outcome measures are neuropsychological assessments of verbal retrieval, and the secondary measures are neuropsychological assessments of other cognitive abilities and electroencephalography (EEG) measures. Additionally, the study will examine the degree to which baseline assessments of cognition and concussion history predict responses to treatment over time, both on assessments administered within the intervention period and at follow-up.

Treatment of Cognitive Deficits in Multiple Sclerosis With High-Definition Transcranial Direct Current Stimulation

Treatment of Cognitive Deficits in Multiple Sclerosis With High-Definition Transcranial Direct Current Stimulation

Condition
Multiple Sclerosis, Relapsing-Remitting
Intervention / Treatment

-

Contacts and Locations

Richardson

The University of Texas at Dallas, Richardson, Texas, United States, 75080

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * dementia of any type
  • * epilepsy or other seizure disorders
  • * severe traumatic brain injury
  • * brain tumor
  • * present drug abuse
  • * stroke
  • * blood vessel abnormalities in the brain
  • * Parkinson's disease
  • * Huntington's disease
  • * anti-convulsants
  • * L-dopa
  • * carbamazepine
  • * sulpiride
  • * pergolide
  • * lorazepam
  • * rivastigmine
  • * dextromethorphan
  • * D-cycloserine
  • * flunarizine
  • * ropinirole
  • * stimulants (dextroamphetamine/amphetamine/modafinil/armodafinil) must be stopped during enrollment

Ages Eligible for Study

18 Years to 65 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

The University of Texas at Dallas,

John Hart, Jr, MD, PRINCIPAL_INVESTIGATOR, University of Texas at Dallas

Study Record Dates

2027-06-30