RECRUITING

Thromboxane Function in Women With Endometriosis

Description

The goal of this clinical trial is to compare neurovascular regulation in women with endometriosis and healthy women. The main questions it aims to answer are: * Do women with endometriosis have greater blood pressure and pain responses to a stimulus than healthy women? * Do women with endometriosis have greater platelet activity than healthy women? Participants will take aspirin and/or placebo and will: * perform hand grip exercise and cold pressor tests * undergo iontophoresis and blood draw Researchers will compare women with and without endometriosis to see if there is a difference in neurovascular regulation.

Conditions

Study Overview

Study Details

Study overview

The goal of this clinical trial is to compare neurovascular regulation in women with endometriosis and healthy women. The main questions it aims to answer are: * Do women with endometriosis have greater blood pressure and pain responses to a stimulus than healthy women? * Do women with endometriosis have greater platelet activity than healthy women? Participants will take aspirin and/or placebo and will: * perform hand grip exercise and cold pressor tests * undergo iontophoresis and blood draw Researchers will compare women with and without endometriosis to see if there is a difference in neurovascular regulation.

The Role of Thomboxane A2 and it's Receptor in Vascular Regulation in Women With Endometriosis

Thromboxane Function in Women With Endometriosis

Condition
Endometriosis
Intervention / Treatment

-

Contacts and Locations

University Park

Noll Laboratory, University Park, Pennsylvania, United States, 16802

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Born with a uterus
  • * 18-45 years old
  • * With and without endometriosis
  • * Currently pregnant or breastfeeding
  • * Diagnosed cardiovascular disease
  • * BMI over 35
  • * Nicotine use (e.g., smoking, chewing tobacco, vaping, etc.)
  • * Currently using hormone replacement therapy (or have used within previous 6 months)
  • * Known skin allergies or current rash, skin disease, disorders of pigmentation
  • * Diabetes
  • * Renal disease, renal artery stenosis, renal impairment
  • * Liver disease
  • * Stage II Hypertension (blood pressure \>140/\>90 mmHg)
  • * Hypotension (blood pressure \< 90/60 mmHg)
  • * Raynaud's syndrome
  • * Any current medications which could conceivably alter cardiovascular responses (e.g. antihypertension medication, diuretic, digoxin)
  • * Allergy or hypersensitivity to investigational agents
  • * Immunosuppressed/immunocompromised

Ages Eligible for Study

18 Years to 45 Years

Sexes Eligible for Study

FEMALE

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Penn State University,

Study Record Dates

2027-08-01