RECRUITING

PRT for Adolescents With High Functioning Autism

Conditions

Autism Autism Spectrum Disorder High-Functioning Developmental Disability Child Development Behavior, Child Behavior, Social Autism Spectrum Disorder PRT Pivotal Response Treatment Autism intervention Social skills Adolescents

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The purpose of this study is to identify improvement in behavioral and social function and changes in the brain following Pivotal Response Treatment (PRT) for Adolescents in highly verbal adolescents with autism spectrum disorder (ASD).

Official Title

Pivotal Response Treatment for Adolescents With High Functioning Autism Intervention Study

Quick Facts

Study Start:2023-09-01

Study Completion:2026-08-31

Study Type:Not specified

Phase:Not Applicable

Enrollment:Not specified

Status:RECRUITING

Study ID

NCT05987761

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:11 Years to 14 Years

Sexes Eligible for Study:ALL

Accepts Healthy Volunteers:No

Standard Ages:CHILD

Inclusion Criteria	Exclusion Criteria
* Clinical Diagnosis of Autism Spectrum Disorder, higher functioning/low support needs * Intelligence Quotient (IQ): Participants with a Full Scale IQ \> 80 on the Wechsler Abbreviated Scale of Intelligence (WASI-II) * Right-handed * No metal in their body/unremovable metal on their body (i.e., braces) * First language is English * Must live in the San Francisco Bay Area * Able and willing to receive intervention weekly for 9 weeks * Adolescent is interested in improving their social skills * MRI Compatibility: No major contraindication for MRI. * Diagnosis of ASD using ADOS-2 and ADI-R. * No evidence of a genetic, metabolic, or infectious etiology for their autism. * Primary diagnosis of ASD * No evidence of significant difficulty during pregnancy, labor, delivery, or immediate neonatal period. * Stable treatment (e.g., ABA), speech therapy, school placement, psychotropic medication(s) or biomedical intervention(s) for at least 1 month prior to baseline measurements with no anticipated changes during study participation. * Score of at least 50% or below on at least 4 out of the 9 social target areas in the SLO (administered during pre-measures) * No evidence of significant difficulty during pregnancy, labor, delivery, or immediate neonatal period.	* History of claustrophobia, previous head injury, serious neurological or medical illness, birth weight less than 4 lb. and/or gestational age \< 34 weeks * Left-handed * Braces or any metal in their body

Inclusion Criteria

Exclusion Criteria

* Clinical Diagnosis of Autism Spectrum Disorder, higher functioning/low support needs
* Intelligence Quotient (IQ): Participants with a Full Scale IQ \> 80 on the Wechsler Abbreviated Scale of Intelligence (WASI-II)
* Right-handed
* No metal in their body/unremovable metal on their body (i.e., braces)
* First language is English
* Must live in the San Francisco Bay Area
* Able and willing to receive intervention weekly for 9 weeks
* Adolescent is interested in improving their social skills
* MRI Compatibility: No major contraindication for MRI.
* Diagnosis of ASD using ADOS-2 and ADI-R.
* No evidence of a genetic, metabolic, or infectious etiology for their autism.
* Primary diagnosis of ASD
* No evidence of significant difficulty during pregnancy, labor, delivery, or immediate neonatal period.
* Stable treatment (e.g., ABA), speech therapy, school placement, psychotropic medication(s) or biomedical intervention(s) for at least 1 month prior to baseline measurements with no anticipated changes during study participation.
* Score of at least 50% or below on at least 4 out of the 9 social target areas in the SLO (administered during pre-measures)
* No evidence of significant difficulty during pregnancy, labor, delivery, or immediate neonatal period.

* History of claustrophobia, previous head injury, serious neurological or medical illness, birth weight less than 4 lb. and/or gestational age \< 34 weeks
* Left-handed
* Braces or any metal in their body

Contacts and Locations

Principal Investigator

Dani A Abrams, Ph.D.

PRINCIPAL_INVESTIGATOR

Stanford University

Study Locations (Sites)

Stanford Research Park

Palo Alto, California, 94304

United States

Collaborators and Investigators

Sponsor: Stanford University

Dani A Abrams, Ph.D., PRINCIPAL_INVESTIGATOR, Stanford University

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2023-09-01

Study Completion Date2026-08-31

Study Record Updates

Study Start Date2023-09-01

Study Completion Date2026-08-31

Terms related to this study

Keywords Provided by Researchers

Autism
Autism Spectrum Disorder
PRT
Pivotal Response Treatment
Autism intervention
Social skills
Adolescents

Additional Relevant MeSH Terms

Autism
Autism Spectrum Disorder High-Functioning
Developmental Disability
Child Development
Behavior, Child
Behavior, Social