COMPLETED

Comparison of a Morphomic-Based to the Standard-of-Care-Based Cefazolin Dose for Antimicrobial Prophylaxis

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The goal of this clinical study is to compare the dosing of an antibiotic in overweight patients having surgery. The main question\[s\] it aims to answer are: * Are the antibiotic concentrations in blood and fat tissue in patients that are overweight sufficient to prevent the chance of infection? * Can dosing using body composition rather than body weight improve the chance of achieving good antibiotic concentrations in overweight patients? Participants will allow us to collect small amounts of blood and fat tissue during their regularly scheduled surgery. Researchers will compare differences in antibiotic concentrations based on dosing by standard of care (body weight based) versus body composition.

Official Title

Comparison of a Morphomic-Based to the Standard-of-Care-Based Cefazolin Dose for Antimicrobial Prophylaxis

Quick Facts

Study Start:2023-03-08
Study Completion:2025-10-01
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:COMPLETED

Study ID

NCT06005168

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. 1. Accessible abdominal computed tomography scan prior to surgery
  2. 2. Adult patients \> 18 years of age
  3. 3. Body Mass Index ≥ 25 kg/m\^2
  4. 4. Expected to receive cefazolin prior to surgical incision
  5. 5. Estimated creatinine clearance ≥90 mL/min
  1. 1. History of a hypersensitivity reaction to penicillin or cephalosporin
  2. 2. Pregnancy

Contacts and Locations

Study Locations (Sites)

University of Michigan Hospital
Ann Arbor, Michigan, 48108
United States

Collaborators and Investigators

Sponsor: University of Michigan

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2023-03-08
Study Completion Date2025-10-01

Study Record Updates

Study Start Date2023-03-08
Study Completion Date2025-10-01

Terms related to this study

Keywords Provided by Researchers

  • Surgical Prophylaxis
  • Pharmacokinetics
  • Cefazolin
  • Obesity
  • Morphomics
  • Colorectal

Additional Relevant MeSH Terms

  • Surgical Prophylaxis