RECRUITING

Associations Between the Microbiome, Skeletal Muscle Perfusion, and Fitness Status

Description

The purpose of the study is to determine associations between fitness status, bacteria in the mouth, and the blood flow to muscle. This study is trying to find out if fitness status impacts the bacteria that are present in the oral microbiome (environment in the mouth) or the ability of the body to send blood to the skeletal muscle. Participants will complete all or some of the following: * A mouth swab to assess the bacteria in their mouths. * Produce a saliva sample into a tube. * Cycle on a bike until you reach maximum effort. * Undergo blood draws * Wear a 24-hour non-invasive device that monitors blood pressure. * Undergo a test to assess blood flow to the muscles measured with an ultrasound. * Drink 70mL (1/3 of a cup) of concentrated beetroot juice once

Conditions

Heart Failure, SystolicHeart Failure, DiastolicPeripheral Arterial DiseaseOverweight and Obesity
Talk to us

Related Conditions:

Heart Failure, SystolicHeart Failure, DiastolicPeripheral Arterial DiseaseOverweight and Obesity

Study Overview

On this page

Study Details

Study overview

The purpose of the study is to determine associations between fitness status, bacteria in the mouth, and the blood flow to muscle. This study is trying to find out if fitness status impacts the bacteria that are present in the oral microbiome (environment in the mouth) or the ability of the body to send blood to the skeletal muscle. Participants will complete all or some of the following: * A mouth swab to assess the bacteria in their mouths. * Produce a saliva sample into a tube. * Cycle on a bike until you reach maximum effort. * Undergo blood draws * Wear a 24-hour non-invasive device that monitors blood pressure. * Undergo a test to assess blood flow to the muscles measured with an ultrasound. * Drink 70mL (1/3 of a cup) of concentrated beetroot juice once

Associations Between the Microbiome, Skeletal Muscle Perfusion, and Fitness Status

Associations Between the Microbiome, Skeletal Muscle Perfusion, and Fitness Status

Condition
Heart Failure, Systolic
Intervention / Treatment

-

Contacts and Locations

Charlottesville

UVA Student Health and Wellness Building, Charlottesville, Virginia, United States, 22903

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Subjects must be able to communicate meaningfully with the investigator and must be legally competent to provide written informed consent.
  • * Subjects may be of either sex with age 18 years.
  • * Oral antibiotic use within previous four weeks
  • * Oral disease or poor oral health as determined by the Oral Health Questionnaire
  • * Using an antibacterial mouthwash or a mouthwash containing chlorhexidine and unwilling to discontinue use
  • * Tobacco smokers
  • * Pregnant or lactating females
  • * Hypersensitivity to any ultrasound contrast agent
  • * Inability to perform exercise
  • * Unable to communicate effectively in English to the study team.
  • * Diagnosis of chronic renal failure (GFR \< 60 ml/min/1.73m)
  • * Subjects taking nitroglycerine (or inorganic nitrates), PDE-5 inhibitors (ex: Cialis, Viagra), and xanthine oxidase inhibitors (ex: Allopurinol).

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

University of Virginia,

Jason D Allen, PhD, PRINCIPAL_INVESTIGATOR, University of Virginia

Study Record Dates

2024-08-07