RECRUITING

Single-tracer Multiparametric PET Imaging

Talk to us

Conditions

Healthy SubjectsCardiovascular Diseasetotal body positron emission tomography

Quick Navigation

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The overarching goal of this project is to develop and evaluate a single-tracer multiparametric positron emission tomography (PET) imaging solution for simultaneous imaging of blood flow and glucose metabolism using 18F-fluorodeoxyglucose (FDG) alone. The investigators working hypothesis is that quantitative blood flow can be extracted from dynamic 18F-FDG PET data by use of tracer kinetic modeling, in addition to glucose metabolism that 18F-FDG is conventionally used for.

Official Title

Single-tracer Multiparametric PET Imaging

Quick Facts

Study Start:2024-02-14
Study Completion:2033-08
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06014515

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. 1. Inclusion Criteria for all research participants:
  2. * Adults (age ≥ 18 years old)
  3. * Ability to understand and willingness to sign an informed consent form
  4. * Ability to adhere to the study visit schedule and other protocol requirements.
  5. * Willing and able to fast for at least 6 hours before and for the duration of the scan
  6. * No strenuous exercise for 24 hours prior to being scanned
  7. * Willing to lie on the scanner bed for up to 60 minutes
  8. * Free of active COVID-19 symptoms
  9. 2. Inclusion Criteria for healthy volunteers only:
  10. 3. Inclusion Criteria for patients with disease:
  11. * Patients with clinically acute or chronic conditions such as cardiovascular, cardiometabolic, or cardiopulmonary diseases, which may include but are not limited to ischemic heart disease, myocarditis, arrhythmias, heart failure, nonalcoholic fatty liver disease, COVID-related sequala, diabetes, hypertension, or renal disease that would result in changes in normal tissue perfusion and/or metabolism.
  1. * Self-reported history of dysphoria or anxiety in closed spaces
  2. * Body weight \>240 kg due to limitations of the scanner bed
  3. * Pregnant or breast-feeding (due to risks of ionizing radiation; urine pregnancy test will be administered prior to start of each PET/CT session for all participants between 18 to 60 years old who are able to get pregnant, unless documented hysterectomy or bilateral ovarian removal is available)
  4. * Blood glucose greater than 200 as assessed by fingerstick method before injection of 18F-FDG
  5. * Concurrent or prior enrollment in a separate research study involving a PET scan performed within the last 12 months for research purposes only.
  6. * Prisoners
  7. * Any condition that would prevent the understanding or rendering of informed consent.
  8. * Any comorbidity that, in the opinion of the investigator, could compromise protocol objectives.

Contacts and Locations

Study Contact

Lynda Painting, BS
CONTACT
9167319004
lpainting@ucdavis.edu
Dana Little, MS
CONTACT
916-734-7749
dalittle@ucdavis.edu

Principal Investigator

Guobao Wang, PhD
PRINCIPAL_INVESTIGATOR
University of California, Davis

Study Locations (Sites)

UC Davis EXPLORER Molecular Imaging Center
Sacramento, California, 95816
United States

Collaborators and Investigators

Sponsor: University of California, Davis

  • Guobao Wang, PhD, PRINCIPAL_INVESTIGATOR, University of California, Davis

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2024-02-14
Study Completion Date2033-08

Study Record Updates

Study Start Date2024-02-14
Study Completion Date2033-08

Terms related to this study

Keywords Provided by Researchers

  • total body positron emission tomography

Additional Relevant MeSH Terms

  • Healthy Subjects
  • Cardiovascular Disease