RECRUITING

Accelerated TMS for Focal Hand Dystonia

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

This study aims to investigate the impact of accelerated transcranial magnetic stimulation (TMS) on brain function and behavior in patients with focal hand dystonia. Previous research demonstrated that individualized TMS improved dystonic behavior after one session. Building on this, the current study administers four TMS sessions in a day, with assessments conducted in four weeks, twelve weeks, and 20 weeks after each session. The research involves 8 in-person and 6 virtual visits focused on functional MRI brain scans and writing behavior analysis. The potential risk of seizures from TMS is mitigated through careful screening, adhering to safety guidelines. The study's main benefit is enhancing dystonic behavior and deepening the understanding of brain changes caused by TMS in focal hand dystonia, paving the way for further advancements in clinical therapy for this condition.

Official Title

Duke Accelerated Transcranial Magnetic Stimulation for Focal Hand Dystonia

Quick Facts

Study Start:2023-12-21
Study Completion:2025-12-31
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06015672

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * 18yrs and older
  2. * Diagnosed with isolated focal hand by Neurologist
  3. * Right-hand dominant
  4. * Must be able to sign an informed consent
  5. * Must be literate
  1. * Other neurological movement disorders diagnoses including other types of dystonia, Parkinsonism, or essential tremor
  2. * History of seizure disorder
  3. * Concomitant medications are known to decrease seizure threshold
  4. * Illicit drug use
  5. * No TMS therapy for another indication within one month of this research study
  6. * Botulinum toxin injections within 3months of the research study
  7. * Medications used for symptom treatment of dystonia including anticholinergic, benzodiazepines, and muscle relaxants among others within one month of the study
  8. * No physical or occupational therapy of the hand within one month of the study
  9. * Any contraindications to MRI or TMS

Contacts and Locations

Study Contact

Noreen Bukhari-Parlakturk, MD PhD
CONTACT
(919) 668-2879
movdisres@dm.duke.edu
Alaa Norain, MBS
CONTACT
(919) 668-2879
movdisres@dm.duke.edu

Principal Investigator

Noreen Bukhari-Parlakturk, MD PhD
PRINCIPAL_INVESTIGATOR
Duke Health

Study Locations (Sites)

Duke University Health System
Durham, North Carolina, 27705
United States

Collaborators and Investigators

Sponsor: Duke University

  • Noreen Bukhari-Parlakturk, MD PhD, PRINCIPAL_INVESTIGATOR, Duke Health

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2023-12-21
Study Completion Date2025-12-31

Study Record Updates

Study Start Date2023-12-21
Study Completion Date2025-12-31

Terms related to this study

Additional Relevant MeSH Terms

  • Isolated Focal Hand Dystonia