RECRUITING

Alendronate for Osteonecrosis in Adults With Sickle Cell Disease

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

A prospective, single-arm, intervention study of oral alendronate in adults with sickle cell disease and osteonecrosis

Official Title

A Feasibility Study of Alendronate as Treatment for Osteonecrosis in Adults With Sickle Cell Disease

Quick Facts

Study Start:2026-02-09
Study Completion:2027-12-31
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06016634

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 80 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Age 18-80 years with SCD (any genotype, confirmed by hemoglobin electrophoresis or high performance liquid chromatography)
  2. * Ability to provide written informed consent
  3. * Ability to lay on a dual-energy X-ray absorptiometry (DXA) scanner
  4. * Negative urine pregnancy test for anyone of childbearing potential at study entry
  1. * Pregnant women
  2. * Adults unable to consent
  3. * Individuals who are not yet adults (infants, children, teenagers)
  4. * Prisoners
  5. * Hospitalizations (for any cause) within 2 weeks of study entry

Contacts and Locations

Study Contact

Leyla Y Teos, PhD
CONTACT
(916) 460-2749
lyteos@ucdavis.edu

Principal Investigator

Oyebimpe O Adesina, MD, MS
PRINCIPAL_INVESTIGATOR
UC Davis School of Medicine

Study Locations (Sites)

UC Davis Comprehensive Cancer Center
Sacramento, California, 95817
United States

Collaborators and Investigators

Sponsor: University of California, Davis

  • Oyebimpe O Adesina, MD, MS, PRINCIPAL_INVESTIGATOR, UC Davis School of Medicine

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2026-02-09
Study Completion Date2027-12-31

Study Record Updates

Study Start Date2026-02-09
Study Completion Date2027-12-31

Terms related to this study

Keywords Provided by Researchers

  • sickle cell disease
  • sickle cell anemia
  • osteonecrosis of the femoral head
  • hip osteonecrosis
  • ischemic necrosis of the femur
  • avascular necrosis of the femur

Additional Relevant MeSH Terms

  • Sickle Cell Disease
  • Sickle Cell Anemia
  • Osteonecrosis
  • Ischemic Necrosis
  • Avascular Necrosis