RECRUITING

Fluad vs. Fluzone High-Dose Vaccine Effectiveness Among Adults ≥65 Years

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

This study will evaluate the relative vaccine effectiveness of quadrivalent adjuvanted inactivated influenza vaccine (aIIV4) versus quadrivalent high-dose inactivated influenza vaccine (HD-IIV4) in preventing polymerase chain reaction (PCR)-confirmed influenza and influenza-related outcomes in adults ≥65 years of age during the 2023/24 and 2024/25 influenza seasons. The study is an observational study conducted at Kaiser Permanente Northern California (KPNC), an integrated health care system in the United States.

Official Title

Relative Vaccine Effectiveness of Adjuvanted Quadrivalent Inactivated Influenza Vaccine vs High-Dose Quadrivalent Inactivated Influenza Vaccine Among Adults ≥65 Years for the 2023-24 and 2024-25 Seasons

Quick Facts

Study Start:2023-08-17
Study Completion:2026-05
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06029933

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:65 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Age ≥65 years at the time of influenza vaccination
  2. * KPNC member at the time of vaccination
  3. * Receive either aIIV4 or HD-IIV4 at a KPNC facility during the 2023/24 and/or 2024/25 influenza seasons
  1. * Age \<65 years at the time of influenza vaccination
  2. * Received either aIIV4 or HD-IIV4 in the inpatient setting
  3. * Receive more than one influenza vaccination during a single season period (i.e., 2023/24 or 2024/25 influenza seasons)
  4. * Receive an influenza vaccination outside of KPNC

Contacts and Locations

Study Contact

Amber H. Hyman, PhD, MPH
CONTACT
510-267-7571
Amber.Hyman@kp.org

Study Locations (Sites)

Kaiser Permanente Northern California (entire region)
Oakland, California, 94612
United States

Collaborators and Investigators

Sponsor: Kaiser Permanente

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2023-08-17
Study Completion Date2026-05

Study Record Updates

Study Start Date2023-08-17
Study Completion Date2026-05

Terms related to this study

Additional Relevant MeSH Terms

  • Influenza
  • Community-acquired Pneumonia
  • Cardiovascular Events