RECRUITING

Sonodynamic Therapy in Patients With Recurrent GBM

Conditions

Recurrent Glioblastoma Glioblastoma Multiforme GBM Sonodynamic Therapy Low-Intensity Focused Ultrasound (LIFU)Focused Ultrasound 5-ALA Brain Cancer

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

Patients diagnosed with glioblastoma (GBM) are faced with limited treatment options. This pilot study will evaluate the safety and feasibility of combining an investigational drug called 5-ALA with neuronavigation-guided low-intensity focused ultrasound (LIFU) for patients who have recurrent GBM. Focused ultrasound (FUS) can be used to non-invasively destroy tumor tissue while preserving normal tissue. When FUS is combined with 5-ALA, this combinatorial approach is called sonodynamic therapy (SDT), and this investigational therapy is being tested for its ability to cause damage to GBM cells. SDT will take place prior to surgery for recurrent GBM.

Official Title

Pilot Study of Sonodynamic Therapy With 5-ALA for the Treatment of Recurrent Glioblastoma Using Neuronavigation-Guided Low-Intensity Focused Ultrasound

Quick Facts

Study Start:2024-01-31

Study Completion:2026-06

Study Type:Not specified

Phase:Not Applicable

Enrollment:Not specified

Status:RECRUITING

Study ID

NCT06039709

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 80 Years

Sexes Eligible for Study:ALL

Accepts Healthy Volunteers:No

Standard Ages:ADULT, OLDER_ADULT

Inclusion Criteria	Exclusion Criteria
1. Disease status and Disease Parameters: * Suspected recurrent glioblastoma that is clearly measurable based on the modified Response Assessment in Neuro-Oncology (RANO) criteria * The tumor lesion needs to comprise at least 1 contrast-enhancing lesion with a volume of ≥ 6 cm3 and ≤ 20 cm3 of targeted treatment area * Tumor tissue to be treated is in a surgically accessible brain region for resection * The brain tumor to be treated must be in the treatment envelope of the NaviFUS system (30 mm to 80 mm from the inner skull table) * Recurrence will be assessed by imaging and confirmed by consensus at tumor board 2. Men or women between the ages of 18-80 years of age at the time of consent 3. No contraindication to repeat brain surgery 4. Karnofsky Performance Score of 70-100 5. Able to undergo an MRI with contrast 6. Able to swallow oral medications 7. Willingness and ability to comply with scheduled visits, treatment plans, lifestyle considerations, laboratory tests, and other procedures. 8. Ability to understand and the willingness to sign a written informed consent document (personally or by the legally authorized representative, if applicable). 9. Participants who received prior chemotherapy, radiation therapy, immunotherapy, and/or another investigational therapy must have recovered (Common Terminology Criteria for Adverse Events \[CTCAE\] Grade ≤1 or baseline) from the acute effects of the therapy or therapies) except for residual alopecia or Grade 2 peripheral neuropathy prior to registration. 10. Has adequate bone marrow and organ function as defined by the following laboratory values (as assessed by the local laboratory for eligibility): * Absolute neutrophil count (ANC) ≥1000/mm3 * Platelets ≥ 100,000/mm3 * Hemoglobin ≥ 11 g/dL for women and ≥ 12 g/dL for men Participants may receive erythrocyte transfusions to achieve this hemoglobin level at the discretion of the investigator. * INR ≤ 1.4 * Creatinine clearance CrCl ≥ 60 mL/min/1.73 m2 as estimated by the Cockcroft-Gault (C-G) equation. If estimated CrCl is abnormal, accurate measurement should be obtained by 24- hour CrCl. * Bilirubin ≤ 1.5 x ULN (except in patients with Gilbert's disease, where bilirubin to 2.0x ULN is allowed). * AST and ALT ≤ 3 x ULN * Alkaline phosphatase ≤ 3 x ULN * GGT ≤ 3 x ULN * Estimated glomerular filtration rate ≥30mL/min/1.73m2	1. Known sensitivity or allergy to 5-ALA 2. Simultaneous use of other potentially phototoxic substances (e.g. tetracyclines, sulfonamides, fluoroquinolones, hypericin extracts) 3. Diagnosis of porphyria 4. Hypersensitivity against porphyrins 5. Pregnancy 6. Significant cardiac disease or coagulopathy 7. Herniation / intractable seizure / other clinical indications requiring urgent resection 8. Known active systemic bacterial infection (requiring intravenous \[IV\] antibiotics at time of initiating study treatment), fungal infection, or detectable viral infection (such as known human immunodeficiency virus positivity or with known active hepatitis B or C (for example, hepatitis B surface antigen positive) 9. Have had a recent (≤3 months prior to registration) transient ischemic attack or stroke 10. Significant vascular disease (e.g. aortic aneurysm) 11. Evidence of bleeding diathesis or coagulopathy 12. Need for systemic anticoagulation which cannot be held for 7 days prior to SDT 13. Unstable angina and/or congestive heart failure (NYH Class III or Class IV; see section 13.2) within 6 months prior to registration 14. Severe hypertension (systolic ≥ 180 mm Hg; diastolic ≥ 120 mm Hg) despite anti-hypertensive medications 15. Transmural myocardial infarction within 6 months prior to registration 16. Serious and inadequately controlled cardiac arrhythmia 17. Acute exacerbation of chronic obstructive pulmonary disease 18. Has serious and/or uncontrolled preexisting medical condition(s) that, in the judgment of the investigator, would preclude participation in this study 19. Treatment with another investigational drug or investigational procedure within 30 days prior to registration or within 5 half-lives of the investigational product, whichever is longer 20. Brain edema and/or mass effect that causes midline shift of more than 15 mm 21. Evidence of recent (within 30 days prior to registration) intracranial hemorrhage 22. Calcifications or metallic implanted objects in the focused ultrasound sonication path 23. Scalp atrophy or scars at the expected location of transducer 24. Cerebral or systemic vasculopathy 25. Need for or currently on dialysis 26. Respiratory: chronic pulmonary disorders (e.g., severe emphysema, COPD, pulmonary vasculitis, or other causes of reduced pulmonary vascular cross-sectional area). 27. Receipt of radiotherapy ≤21 days prior to registration 28. Receipt of chemotherapy ≤ 21 days prior to registration 29. Prior treatment with sonodynamic therapy 30. Concurrent use of Optune device 31. Concurrent use of supplements or medications with substantial antioxidant effects (including sulfhydryl-containing medications such as captopril or supplements such as N-acetylcysteine, or high doses of vitamins with antioxidant activity such as C or E) 32. Known sensitivity to gadolinium

Inclusion Criteria

Exclusion Criteria

1. Disease status and Disease Parameters:
* Suspected recurrent glioblastoma that is clearly measurable based on the modified Response Assessment in Neuro-Oncology (RANO) criteria
* The tumor lesion needs to comprise at least 1 contrast-enhancing lesion with a volume of ≥ 6 cm3 and ≤ 20 cm3 of targeted treatment area
* Tumor tissue to be treated is in a surgically accessible brain region for resection
* The brain tumor to be treated must be in the treatment envelope of the NaviFUS system (30 mm to 80 mm from the inner skull table)
* Recurrence will be assessed by imaging and confirmed by consensus at tumor board
2. Men or women between the ages of 18-80 years of age at the time of consent
3. No contraindication to repeat brain surgery
4. Karnofsky Performance Score of 70-100
5. Able to undergo an MRI with contrast
6. Able to swallow oral medications
7. Willingness and ability to comply with scheduled visits, treatment plans, lifestyle considerations, laboratory tests, and other procedures.
8. Ability to understand and the willingness to sign a written informed consent document (personally or by the legally authorized representative, if applicable).
9. Participants who received prior chemotherapy, radiation therapy, immunotherapy, and/or another investigational therapy must have recovered (Common Terminology Criteria for Adverse Events \[CTCAE\] Grade ≤1 or baseline) from the acute effects of the therapy or therapies) except for residual alopecia or Grade 2 peripheral neuropathy prior to registration.
10. Has adequate bone marrow and organ function as defined by the following laboratory values (as assessed by the local laboratory for eligibility):
* Absolute neutrophil count (ANC) ≥1000/mm3
* Platelets ≥ 100,000/mm3
* Hemoglobin ≥ 11 g/dL for women and ≥ 12 g/dL for men Participants may receive erythrocyte transfusions to achieve this hemoglobin level at the discretion of the investigator.
* INR ≤ 1.4
* Creatinine clearance CrCl ≥ 60 mL/min/1.73 m2 as estimated by the Cockcroft-Gault (C-G) equation. If estimated CrCl is abnormal, accurate measurement should be obtained by 24- hour CrCl.
* Bilirubin ≤ 1.5 x ULN (except in patients with Gilbert's disease, where bilirubin to 2.0x ULN is allowed).
* AST and ALT ≤ 3 x ULN
* Alkaline phosphatase ≤ 3 x ULN
* GGT ≤ 3 x ULN
* Estimated glomerular filtration rate ≥30mL/min/1.73m2

1. Known sensitivity or allergy to 5-ALA
2. Simultaneous use of other potentially phototoxic substances (e.g. tetracyclines, sulfonamides, fluoroquinolones, hypericin extracts)
3. Diagnosis of porphyria
4. Hypersensitivity against porphyrins
5. Pregnancy
6. Significant cardiac disease or coagulopathy
7. Herniation / intractable seizure / other clinical indications requiring urgent resection
8. Known active systemic bacterial infection (requiring intravenous \[IV\] antibiotics at time of initiating study treatment), fungal infection, or detectable viral infection (such as known human immunodeficiency virus positivity or with known active hepatitis B or C (for example, hepatitis B surface antigen positive)
9. Have had a recent (≤3 months prior to registration) transient ischemic attack or stroke
10. Significant vascular disease (e.g. aortic aneurysm)
11. Evidence of bleeding diathesis or coagulopathy
12. Need for systemic anticoagulation which cannot be held for 7 days prior to SDT
13. Unstable angina and/or congestive heart failure (NYH Class III or Class IV; see section 13.2) within 6 months prior to registration
14. Severe hypertension (systolic ≥ 180 mm Hg; diastolic ≥ 120 mm Hg) despite anti-hypertensive medications
15. Transmural myocardial infarction within 6 months prior to registration
16. Serious and inadequately controlled cardiac arrhythmia
17. Acute exacerbation of chronic obstructive pulmonary disease
18. Has serious and/or uncontrolled preexisting medical condition(s) that, in the judgment of the investigator, would preclude participation in this study
19. Treatment with another investigational drug or investigational procedure within 30 days prior to registration or within 5 half-lives of the investigational product, whichever is longer
20. Brain edema and/or mass effect that causes midline shift of more than 15 mm
21. Evidence of recent (within 30 days prior to registration) intracranial hemorrhage
22. Calcifications or metallic implanted objects in the focused ultrasound sonication path
23. Scalp atrophy or scars at the expected location of transducer
24. Cerebral or systemic vasculopathy
25. Need for or currently on dialysis
26. Respiratory: chronic pulmonary disorders (e.g., severe emphysema, COPD, pulmonary vasculitis, or other causes of reduced pulmonary vascular cross-sectional area).
27. Receipt of radiotherapy ≤21 days prior to registration
28. Receipt of chemotherapy ≤ 21 days prior to registration
29. Prior treatment with sonodynamic therapy
30. Concurrent use of Optune device
31. Concurrent use of supplements or medications with substantial antioxidant effects (including sulfhydryl-containing medications such as captopril or supplements such as N-acetylcysteine, or high doses of vitamins with antioxidant activity such as C or E)
32. Known sensitivity to gadolinium

Contacts and Locations

Study Contact

Zachary Sturgill

CONTACT

434-243-9986

FFM7RC@uvahealth.org

Judith Beenhakker, M.S.

CONTACT

434-982-1856

jgb3p@uvahealth.org

Principal Investigator

Shayan Moosa, MD

PRINCIPAL_INVESTIGATOR

UVA

Study Locations (Sites)

University of Virginia

Charlottesville, Virginia, 22903

United States

Collaborators and Investigators

Sponsor: Shayan Moosa, MD

Shayan Moosa, MD, PRINCIPAL_INVESTIGATOR, UVA

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2024-01-31

Study Completion Date2026-06

Study Record Updates

Study Start Date2024-01-31

Study Completion Date2026-06

Terms related to this study

Keywords Provided by Researchers

Sonodynamic Therapy
Low-Intensity Focused Ultrasound (LIFU)
Focused Ultrasound
5-ALA
Brain Cancer

Additional Relevant MeSH Terms

Recurrent Glioblastoma
Glioblastoma Multiforme
GBM