RECRUITING

Investigation of Locus Coeruleus Function in Sustained Attention

Description

The norepinephrine-producing locus coeruleus (LC) is thought to be central to a wide array of cognitive functions, like attention and goal pursuit, and has been implicated in dysfunctions including attention deficit hyperactivity disorder and schizophrenia. The goal of this proposal is to develop methods that permit measurement of activity in the human LC. Because the LC is small and located in the pons, the Investigators will use high resolution magnetic resonance imaging techniques tailored to the brainstem environment, including neuromelanin-sensitive images shown to delineate the LC, combined with pharmacological manipulation to confirm the location of functional activity.

Conditions

Attention - No Condition is Being Assessed - Healthy Adults
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Attention - No Condition is Being Assessed - Healthy Adults

Study Overview

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Study Details

Study overview

The norepinephrine-producing locus coeruleus (LC) is thought to be central to a wide array of cognitive functions, like attention and goal pursuit, and has been implicated in dysfunctions including attention deficit hyperactivity disorder and schizophrenia. The goal of this proposal is to develop methods that permit measurement of activity in the human LC. Because the LC is small and located in the pons, the Investigators will use high resolution magnetic resonance imaging techniques tailored to the brainstem environment, including neuromelanin-sensitive images shown to delineate the LC, combined with pharmacological manipulation to confirm the location of functional activity.

Investigation of Locus Coeruleus Function in Sustained Attention

Investigation of Locus Coeruleus Function in Sustained Attention

Condition
Attention - No Condition is Being Assessed - Healthy Adults
Intervention / Treatment

-

Contacts and Locations

Sacramento

University of California, Davis, Sacramento, California, United States, 95817

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Between the ages of 18 - 60 years of age,
  • * Typically developing, healthy adult
  • * History of schizophrenia, other forms of psychosis,
  • * Specific or focal neurological disorder or severe alcohol or drug use disorder within the past 5 years
  • * History of left ventricular hypertrophy or in patients with mitral valve prolapse who have experienced the mitral valve prolapse syndrome when previously receiving CNS stimulants, or who have had recent history of myocardial infarction or unstable angina.
  • * Volunteers with known hypersensitivity to modafinil or armodafinil or its inactive ingredients
  • * Known allergy/sensitivity or any hypersensitivity to components of modafinil or its formulation
  • * Inability to swallow tablets or tolerate oral medication;
  • * Pregnant or nursing (participants will be required to have a negative pregnancy test)
  • * Contraindication for MRI scanning (metal implants, pacemakers, metal foreign bodies, or pregnancy)
  • * Use of psychotropic medication within the past week
  • * Claustrophobic and not comfortable being in a small space may also not want to participate

Ages Eligible for Study

18 Years to 60 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

University of California, Davis,

Study Record Dates

2025-12-30