COMPLETED

Targeting Trimethylamine N-Oxide for Cardiovascular Health In Liver Transplant Recipients

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

Despite medical and surgical advances, long-term survival in liver transplant (LT) recipients is compromised by an increased risk of cardiovascular disease (CVD) after transplant, the mechanisms of which are still not fully understood. TMAO is an attractive therapeutic target to improve vascular health and diastolic function toward preventing CVD in LT patients. Therefore, the purpose of this study is to better understand the role of TMAO in cardiovascular dysfunction patients with chronic kidney disease.

Official Title

Targeting Trimethylamine N-Oxide for Cardiovascular Health In Liver Transplant Recipients

Quick Facts

Study Start:2024-01-18
Study Completion:2024-10-25
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:COMPLETED

Study ID

NCT06043531

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Aged \> 18 years
  2. * Speak and understand English
  3. * Have received and LT
  1. * Acute cellular or chronic rejection within 3 months
  2. * Post-LT liver or non-liver related malignancy
  3. * Active viral hepatitis (B or C) or autoimmune hepatitis
  4. * Untreated biliary strictures or vascular complications (e.g. hepatic artery thrombosis)
  5. * Poorly controlled diabetes (HbA1c \>8.5%)
  6. * Relapse of alcohol use after LT
  7. * Follow a vegetarian or vegan diet
  8. * Current pregnancy
  9. * Unable to provide informed consent

Contacts and Locations

Principal Investigator

Danielle Kirkman
PRINCIPAL_INVESTIGATOR
Virginia Commonwealth University

Study Locations (Sites)

Virginia Commonwealth University
Richmond, Virginia, 23298
United States

Collaborators and Investigators

Sponsor: Virginia Commonwealth University

  • Danielle Kirkman, PRINCIPAL_INVESTIGATOR, Virginia Commonwealth University

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2024-01-18
Study Completion Date2024-10-25

Study Record Updates

Study Start Date2024-01-18
Study Completion Date2024-10-25

Terms related to this study

Additional Relevant MeSH Terms

  • Liver Transplant