RECRUITING

Virologic and Immunologic Characteristics of Severe Mpox in Persons With Advanced HIV

Description

The purpose of this study is to examine the extent of mpox viral spread and immunologic markers in people with advanced HIV. Study findings will enhance knowledge of mpox pathogenesis in severely immunocompromised people, which can inform treatment and prevention of severe illness and deaths associated with mpox in people with advanced HIV.

Study Overview

Study Details

Study overview

The purpose of this study is to examine the extent of mpox viral spread and immunologic markers in people with advanced HIV. Study findings will enhance knowledge of mpox pathogenesis in severely immunocompromised people, which can inform treatment and prevention of severe illness and deaths associated with mpox in people with advanced HIV.

Virologic and Immunologic Characteristics of Severe Mpox in Persons With Advanced HIV

Virologic and Immunologic Characteristics of Severe Mpox in Persons With Advanced HIV

Condition
Monkeypox
Intervention / Treatment

-

Contacts and Locations

Atlanta

Centers for Disease Control and Prevention, Atlanta, Georgia, United States, 30333

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Age ≥18 years; AND
  • * HIV infection with CD4 count \< 200 cells/uL; AND
  • * Probable or confirmed mpox (does NOT need to be a new diagnosis); AND
  • * Hospitalized while symptomatic from mpox, for reasons other than (or in addition to) infection prevention and control
  • * Inability of the individual or appropriate proxy to provide informed consent.
  • * In the judgment of the clinical treating team, has a medical condition or other factor that might affect their ability to participate in the evaluation.

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Centers for Disease Control and Prevention,

Agam Rao, MD, PRINCIPAL_INVESTIGATOR, Centers for Disease Control and Prevention

Irini Sereti, MD, STUDY_DIRECTOR, National Institutes of Health (NIH)

Faisal Minhaj, Pharm.D., STUDY_DIRECTOR, Centers for Disease Control and Prevention

Shama Cash-Goldwasser, MD, STUDY_DIRECTOR, Centers for Disease Control and Prevention

Jesse OShea, MD, STUDY_DIRECTOR, Centers for Disease Control and Prevention

Christine Hughes, PhD, STUDY_DIRECTOR, Centers for Disease Control and Prevention

Brian Epling, MD, STUDY_DIRECTOR, National Institutes of Health (NIH)

Katy Saliba, PhD, STUDY_DIRECTOR, National Institutes of Health (NIH)

Jason Zucker, MD, STUDY_DIRECTOR, Columbia University

Sarah Reagan Steiner, MD, STUDY_DIRECTOR, Centers for Disease Control and Prevention

Sarah Park, MD, STUDY_DIRECTOR, Karius Laboratories

Study Record Dates

2024-10-01