RECRUITING

Somatic Mosaicism in Twins Discordant for Childhood Cancer

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Conditions

Pediatric Central Nervous System TumorCentral Nervous System TumorDiscordant TwinSomatic Mutation

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

Somatic mosaicism in cancer associated genes is one potential explanation for discordance in childhood cancer that has not been fully explored to date. This pilot study will focus on twins with central nervous system (CNS) tumors who are identified through the Children's Oncology Group's Project: EveryChild (PEC) registry or volunteer.

Official Title

Somatic Mosaicism in Twins Discordant for Childhood Cancer: a Pilot Study

Quick Facts

Study Start:2024-06-03
Study Completion:2025-12-31
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06054295

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:Not specified to 18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:CHILD, ADULT
Inclusion CriteriaExclusion Criteria
  1. * Newly diagnosed patient with CNS tumor or have recurrent disease and enrolled on APEC14B1.
  2. * Patient must have same sex twin. Note: (history of) treatment on a COG therapeutic trial is not required.
  3. * Patients must be diagnosed at \< 19 years of age at the time of diagnosis.
  4. * A family is eligible to participate if the twin with the CNS tumor is deceased but has a blood sample banked through APEC14B1.
  5. * All patients and/or their parents or legal guardians must provide informed consent. Assent will be obtained for participants between the ages of 8-17 years.
  6. * All institutional, FDA, and NCI requirements for human studies must be met.
  1. Pregnancy or breastfeeding
  2. Severe psychiatric disorders
  3. Active substance abuse
  4. Unstable medical conditions
  5. Inability to comply with study requirements

Contacts and Locations

Study Contact

Jenny Poynter, PhD
CONTACT
(612) 625-4232
poynt006@umn.edu

Principal Investigator

Jenny Poynter, PhD
STUDY_CHAIR
University of Minnesota

Study Locations (Sites)

University of Minnesota
Minneapolis, Minnesota, 55455
United States

Collaborators and Investigators

Sponsor: Children's Oncology Group

  • Jenny Poynter, PhD, STUDY_CHAIR, University of Minnesota

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2024-06-03
Study Completion Date2025-12-31

Study Record Updates

Study Start Date2024-06-03
Study Completion Date2025-12-31

Terms related to this study

Additional Relevant MeSH Terms

  • Pediatric Central Nervous System Tumor
  • Central Nervous System Tumor
  • Discordant Twin
  • Somatic Mutation