COMPLETED

Methylphenidate and Response to Alcohol Cues

Conditions

Alcohol Use Disorder Attention Deficit Hyperactivity Disorder fMRI EEG

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The purpose of this study is to determine whether changes in attention levels related to taking a single dose of a medication called methylphenidate, also known as Ritalin, affects responses to alcohol cues. The study will observe the effects of methylphenidate or a placebo on attentional bias and craving responses to alcohol cues through fMRI, EEG, and behavioral testing. Participants will be involved in one remote and two in-person sessions.

Official Title

Methylphenidate and Response to Alcohol Cues (MARA) Pilot Study

Quick Facts

Study Start:2024-03-20

Study Completion:2025-07-01

Study Type:Not specified

Phase:Not Applicable

Enrollment:Not specified

Status:COMPLETED

Study ID

NCT06063200

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 25 Years

Sexes Eligible for Study:ALL

Accepts Healthy Volunteers:Yes

Standard Ages:ADULT

Inclusion Criteria	Exclusion Criteria
* Adults ages 18-25 years * Meets DSM-5 criteria for AUD * Meets DSM-5 criteria for ADHD * Fluent in English * Normal or corrected to normal vision	* Meets DSM-5 criteria for bipolar disorder, psychotic disorders, neurological disorders, or substance use disorders other than AUD. * Participant routinely uses psychoactive drugs or medications except for non-dependent marijuana or nicotine use (due to common use of these substances in individuals with AUD). * Participant has contraindications for taking methylphenidate. * Participant has contraindications for being in an MRI machine * Self-reported history of high blood pressure over 140/90 or consistent readings of 140/90 or above upon arrival for a session. * History of seizure disorder * Liver disease * Participant is currently pregnant or trying to become pregnant

Inclusion Criteria

Exclusion Criteria

* Adults ages 18-25 years
* Meets DSM-5 criteria for AUD
* Meets DSM-5 criteria for ADHD
* Fluent in English
* Normal or corrected to normal vision

* Meets DSM-5 criteria for bipolar disorder, psychotic disorders, neurological disorders, or substance use disorders other than AUD.
* Participant routinely uses psychoactive drugs or medications except for non-dependent marijuana or nicotine use (due to common use of these substances in individuals with AUD).
* Participant has contraindications for taking methylphenidate.
* Participant has contraindications for being in an MRI machine
* Self-reported history of high blood pressure over 140/90 or consistent readings of 140/90 or above upon arrival for a session.
* History of seizure disorder
* Liver disease
* Participant is currently pregnant or trying to become pregnant

Contacts and Locations

Study Locations (Sites)

University of Florida

Gainesville, Florida, 32610

United States

Collaborators and Investigators

Sponsor: University of Florida

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2024-03-20

Study Completion Date2025-07-01

Study Record Updates

Study Start Date2024-03-20

Study Completion Date2025-07-01

Terms related to this study

Keywords Provided by Researchers

fMRI
EEG

Additional Relevant MeSH Terms

Alcohol Use Disorder
Attention Deficit Hyperactivity Disorder