RECRUITING

Etomidate Versus Propofol in CABG Surgery

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The objective of this single-blinded randomized controlled interventional clinical trial is to learn about the efficacy and long-term safety of etomidate compared to propofol as an anesthesia induction agent in patients undergoing coronary artery bypass graft (CABG) surgery. The primary aim of this study is to determine whether patients receiving etomidate or propofol exhibit similar requirements for vasopressor or ionotropic agents during both the intraoperative and postoperative periods. To achieve this goal, participants who are scheduled for CABG surgery will be randomly assigned to receive either etomidate or propofol as the principal hypnotic agent. The researchers will then compare the effects of these two anesthesia induction agents on various factors, including the need for hemodynamic support, hemodynamic stability, duration of mechanical ventilation, length of stay in the intensive care unit (ICU), and overall hospital length of stay. Additionally, they will assess whether there are disparities in mortality rates and readmission rates within a 6-month timeframe after the surgery. By comparing the outcomes between the two groups, the study aims to provide valuable insights into the potential differences in vasopressor or ionotropic agent requirements between etomidate and propofol. This information can help inform clinical decision-making and potentially optimize anesthesia management strategies for patients undergoing CABG surgery.

Official Title

Etomidate Versus Propofol As An Anesthesia Induction Agent For Patients Undergoing CABG Surgery, Assessing Hemodynamic Stability. A Single Blinded, Randomized Controlled Trial.

Quick Facts

Study Start:2023-12-05
Study Completion:2026-08
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06068764

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 90 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. 1. Patients scheduled for elective open coronary arteries bypass graft CABG surgery
  2. 2. Patients with American Society of Anesthesiology (ASA) physical status score I- IV
  3. 3. Patients with the ability to speak and read both English and Spanish
  1. 1. Emergency CABG surgery, STAT cases, and add-on cases.
  2. 2. Refusal or lack of providing the study consent
  3. 3. Patients with a known current adrenocortical insufficiency
  4. 4. A patient who is presenting with any kind of shock, (e.g. septic, hypovolemic, cardiogenic, etc.)
  5. 5. Patients with chronic steroid use (defined as the use of glucocorticoids within 6 months preoperatively)
  6. 6. Patients with a known allergy to etomidate or propofol.
  7. 7. Patients with a known seizure disorder.
  8. 8. Patients who are enrolled in other clinical research studies that can compete with this study.

Contacts and Locations

Study Contact

Aseel Walker, MD
CONTACT
860-972-1778
Aseel.Walker@hhchealth.org

Principal Investigator

Joseph Hinchey, MD
PRINCIPAL_INVESTIGATOR
Hartford Hospital

Study Locations (Sites)

Hartford Hospital
Hartford, Connecticut, 06106
United States

Collaborators and Investigators

Sponsor: Hartford Hospital

  • Joseph Hinchey, MD, PRINCIPAL_INVESTIGATOR, Hartford Hospital

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2023-12-05
Study Completion Date2026-08

Study Record Updates

Study Start Date2023-12-05
Study Completion Date2026-08

Terms related to this study

Keywords Provided by Researchers

  • CABG surgery
  • Etomidate
  • Propofol
  • general anesthesia induction agenats
  • cardiothoracic anesthesia

Additional Relevant MeSH Terms

  • Coronary Artery Disease