RECRUITING

The Computational and Neural Mechanisms Linking Decision-making and Memory in Humans

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

Learning to make good decisions in the present, and accurately recalling events and information from the past, are critical aspects of human cognition that are often impaired in many psychiatric disorders. This project aims to identify the how the choices individuals make influence what, and how, people remember by combining disparate techniques in computational modeling and direct brain recordings in human subjects. The researcher developed a dual-task paradigm, probing how decisions in one task affect immediate recognition memory. To examine the neural mechanisms underlying model-free RL's influence on memory, the researcher will record local field potential (LFP) and single neuron activity in various brain regions as epilepsy patients perform the proposed task. The results of this project will identify specific neurocomputational mechanisms unifying decision-making and memory processes.

Official Title

The Computational and Neural Mechanisms Linking Decision-making and Memory in Humans

Quick Facts

Study Start:2023-10-31
Study Completion:2028-09-01
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06072378

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 65 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Has seizure activity which is deemed non-responsive to standard pharmacological intervention(s), as determined by treating Neurologist and established clinical practices
  2. * Has elected to receive clinically indicated intracranial EEG (electrocorticography (ECoG), stereoelectroencephalography (SEEG)) and/or temporal responsive neurostimulation (RNS) for medication-refractory epilepsy outside of this research study, as determined by treating clinician(s) and per current clinical practice
  3. * Capacity to provide written informed consent
  4. * Language proficiency in English or Spanish
  5. * Willing and able to comply with all study-related procedures
  1. * History of psychosis, such as in the context of depressive or manic episode.
  2. * Active suicidal ideation with intent, suicide attempt within the last six months, or other serious suicide risk
  3. * Inability to provide informed consent or reliably participate in study assessments, as per the Montreal Cognitive Assessment (MOCA; score \< 26) or in the opinion of the evaluating neuropsychologist.
  4. * Individuals unwilling or unable to undergo electrode implantation procedures
  5. * Medical contraindications to neurosurgery or for general anesthesia, neurosurgery, or an MRI scan (required for electrode implantation)
  6. * Neurological disorder other than epilepsy or other significant brain pathology, if contraindicated in the opinion of implanting neurosurgeon.
  7. * Women who are pregnant

Contacts and Locations

Study Contact

Salman E Qasim, PhD
CONTACT
212-824-9531
salman.qasim@mssm.edu

Principal Investigator

Salman E Qasim, PhD
PRINCIPAL_INVESTIGATOR
Icahn School of Medicine at Mt. Sinai

Study Locations (Sites)

Mount Sinai West
New York, New York, 10024
United States

Collaborators and Investigators

Sponsor: Rutgers, The State University of New Jersey

  • Salman E Qasim, PhD, PRINCIPAL_INVESTIGATOR, Icahn School of Medicine at Mt. Sinai

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2023-10-31
Study Completion Date2028-09-01

Study Record Updates

Study Start Date2023-10-31
Study Completion Date2028-09-01

Terms related to this study

Additional Relevant MeSH Terms

  • Memory, Short-Term