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Ketone Conferred Resiliency Against Sleep Restriction With Nutritional Intervention.

Description

Sleep deprivation is a major problem in military populations. Some major consequences of sleep loss are inability to concentrate, poor work efficiency, and increase in errors during daily tasks. Ketogenic supplementation is speculated to alleviate some sleep deprivation issues via action of ketones. Ketones are small molecules that appear in the blood when following a ketogenic diet or consuming ketone supplements. The goal of this project is to find out if diet and/or ketones can improve sleep deprivation detriments over 5 days of sleep restriction (-50% from habitual sleep).

Conditions

Sleep DeprivationNutritional Intervention
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Related Conditions:

Sleep DeprivationNutritional Intervention

Study Overview

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Study Details

Study overview

Sleep deprivation is a major problem in military populations. Some major consequences of sleep loss are inability to concentrate, poor work efficiency, and increase in errors during daily tasks. Ketogenic supplementation is speculated to alleviate some sleep deprivation issues via action of ketones. Ketones are small molecules that appear in the blood when following a ketogenic diet or consuming ketone supplements. The goal of this project is to find out if diet and/or ketones can improve sleep deprivation detriments over 5 days of sleep restriction (-50% from habitual sleep).

Strategies to Augment Ketosis: Ketone Conferred Resiliency Against Sleep Restriction With Nutritional Intervention (STAK - Sleep + Feed)

Ketone Conferred Resiliency Against Sleep Restriction With Nutritional Intervention.

Condition
Sleep Deprivation
Intervention / Treatment

-

Contacts and Locations

Columbus

The Ohio State University, Columbus, Ohio, United States, 43210

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Healthy, 18-40 years old.
  • * BMI: 20-35 kg/m2
  • * Sleep at least 7h per night.
  • * Willing to participate in \~9-weeks of testing and provided food.
  • * Willing to adhere to all study procedures.
  • * \<18 or \>40 years of age
  • * \>35 body mass index (BMI).
  • * Diagnosed sleeping disorders (i.e., sleep apnea, insomnia).
  • * Gastrointestinal disorders or food allergies that would interfere with consuming the study supplements.
  • * Drink alcohol in excess of 3 drinks/day or 14 drinks/week
  • * Have any conditions or contraindications to blood draws.
  • * Have been diagnosed with diabetes, liver, kidney, or other metabolic or endocrine dysfunction, or use diabetic medications other than metformin
  • * Currently consume a low carbohydrate or ketogenic diet or have done so in the last 3 months
  • * Have experienced weight loss of \>10% of your body weight within the last 6 months
  • * Are pregnant, lactating, or planning on becoming pregnant during the study
  • * Have any major psychiatric disorders (e.g., schizophrenia, bipolar disorder)

Ages Eligible for Study

18 Years to 40 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Ohio State University,

Jeff S Volek, PhD, PRINCIPAL_INVESTIGATOR, Ohio State University

Study Record Dates

2026-12