RECRUITING

Emgality for Migraine in Breastmilk

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The goal of this project is to evaluate galcanezumab transfer into maternal breastmilk, and to evaluate infant (growth, development, constipation, colic, infections) and maternal (headache) outcomes for dyads in which the mother was treated with galcanezumab and to compare outcomes for infants who were or were not breastfed after maternal treatment. In this prospective observational study, the study team proposes to prospectively collect serial milk samples from 30 adult women who are treated with galcanezumab for migraine. Mothers who are interested in participating will be connected with us, the main clinical site, by neurologists across the USA. Mothers must carry a diagnosis of migraine, be aged 18-45 years, and be between 14 days and 9 months postpartum, and still nursing, at the time of enrollment. This study will fill a significant unmet need as women of childbearing potential are over-represented in the migraine population, and yet they are excluded from clinical trials of migraine treatments during pregnancy and lactation.

Official Title

Prospective Evaluation of Emgality (Galcanezumab) in Breastmilk in Adult Women With Migraine

Quick Facts

Study Start:2023-12
Study Completion:2026-04
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06085144

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 45 Years
Sexes Eligible for Study:FEMALE
Accepts Healthy Volunteers:No
Standard Ages:ADULT
Inclusion CriteriaExclusion Criteria
  1. * Female
  2. * Childbearing age (18-45)
  3. * Established diagnosis of migraine
  4. * Status post uncomplicated delivery (no long-term maternal complications)
  5. * No prolonged (\>3 night) NICU stay for infant
  6. * Between 14 days and 9 months postpartum, and still nursing, at the time of enrollment
  7. * Planning to receive galcanezumab postpartum
  8. * Suitable candidate to receive galcanezumab postpartum, at discretion of prescribing clinician
  1. * Contraindications to breastfeeding, such as prior surgery or infant contraindications
  2. * Contraindications to galcanezumab or insurance coverage
  3. * Use of gepants
  4. * Moderately Severe or Severe Depression as established by the PHQ9 screen (i.e. score 15 or above)
  5. * Pregnant or planning pregnancy in the coming 6M
  6. * Patients with severe mastitis will not be enrolled; should mastitis occur during the study, this will be included as a covariate and results analyzed accordingly
  7. * Patients of infants with severe medical issues identified in the health record (developmental issues, delivery issues, concomitant medications)

Contacts and Locations

Study Contact

Ayushi D Balan, BA, BS
CONTACT
415-514-8330
ayushi.balan@ucsf.edu
Stephanie Hsu, BA
CONTACT
415-502-7209
stephanie.hsu@ucsf.edu

Principal Investigator

Riley Bove, MD, MSc
PRINCIPAL_INVESTIGATOR
University of California, San Francisco

Study Locations (Sites)

University of California, San Francisco
San Francisco, California, 94158
United States

Collaborators and Investigators

Sponsor: University of California, San Francisco

  • Riley Bove, MD, MSc, PRINCIPAL_INVESTIGATOR, University of California, San Francisco

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2023-12
Study Completion Date2026-04

Study Record Updates

Study Start Date2023-12
Study Completion Date2026-04

Terms related to this study

Keywords Provided by Researchers

  • Emgality
  • Galcanezumab
  • Migraine
  • Breastmilk
  • Milk
  • Breastfeeding
  • Pregnancy
  • Postpartum
  • Monoclonal Antibodies

Additional Relevant MeSH Terms

  • Migraine