ACTIVE_NOT_RECRUITING

Investigating Age-dependent Effects of Egg Intake on HDL and Immune Profiles

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The goal of this intervention study is to determine whether consumption of different fractions of chicken eggs, including egg whites, egg yolks, and whole eggs, confer different changes in markers of HDL function and T cell profiles in younger vs. older men and women. The study will address the following objectives: * Objective 1: Determine if daily consumption of egg fractions differentially alter HDL profiles across age groups. * Objective 2: Determine if daily consumption of egg fractions differentially alter immune cell profiles across age groups. Participants will be asked to consume egg whites, egg yolks, and whole eggs on a daily basis for 4-weeks each, and avoid eating eggs for a total of 8 weeks at different points in the study. Participants will additionally be provided guidance on following a generally healthy diet, and will be asked to complete surveys about dietary intake and physical activity, as well as provide blood samples throughout the course of the study. Researchers will compare whether daily consumption of egg whites, egg yolks, and whole eggs differentially alter markers of HDL function and T cell profiles in younger vs. older adults.

Official Title

Investigating Age-dependent Effects of Egg Intake on HDL and Immune Profiles

Quick Facts

Study Start:2024-01-23
Study Completion:2026-06
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:ACTIVE_NOT_RECRUITING

Study ID

NCT06086795

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 75 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * 18-30 years old, or 50-75 years old (at time of screening)
  2. * Body mass index (BMI) \< 30 kg/m2
  3. * Willing to consume whole eggs, egg whites, or egg yolks on a daily basis during study periods, and refrain from eating eggs during other study periods
  4. * Do not fit any exclusion criteria
  1. * \< 18 years old; 31-49 years old; \> 75 years old
  2. * BMI ≥ 30 kg/m2 or body weight \< 110 pounds
  3. * Weight changes \> 10% over the last 4 weeks
  4. * Self-reported history of diabetes, heart disease, stroke, renal or liver disease, cancer, eating disorders, certain severe and/or relapsing/remitting autoimmune, inflammatory, or metabolic diseases, chronic infections, scleroderma, blood clotting disorders, intravenous drug use, or current pregnancy or lactation
  5. * Allergy or intolerance to eggs, egg components, or egg products
  6. * Implanted medical device (e.g., pacemaker) or other health condition that would prevent measurement of body composition by bioelectrical impedance
  7. * Highly elevated fasting lipid and glucose levels (triglyceride levels higher than 500 mg/dL, fasting glucose higher than 126 mg/dL), or total cholesterol \< 120 mg/dL and HDL-cholesterol \< 15 mg/dL
  8. * Currently taking lipid-lowering medications (e.g. statins, fibrates), anti-inflammatory medications (e.g., NSAIDs, corticosteroids), or medications that primarily affect blood clotting (e.g., warfarin)

Contacts and Locations

Principal Investigator

Catherine J Andersen, PhD, RDN
PRINCIPAL_INVESTIGATOR
University of Connecticut

Study Locations (Sites)

University of Connecticut
Storrs, Connecticut, 06269
United States

Collaborators and Investigators

Sponsor: University of Connecticut

  • Catherine J Andersen, PhD, RDN, PRINCIPAL_INVESTIGATOR, University of Connecticut

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2024-01-23
Study Completion Date2026-06

Study Record Updates

Study Start Date2024-01-23
Study Completion Date2026-06

Terms related to this study

Keywords Provided by Researchers

  • Diet
  • Lipoproteins
  • T-Lymphocytes
  • Eggs
  • Aging

Additional Relevant MeSH Terms

  • Lipoproteins
  • Inflammatory Response