RECRUITING

Normothermic Machine Perfusion of Steatotic Livers for Expansion of Donor Organ Pool

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The goal of this clinical trial is to assess the ability of Normothermic Machine Perfusion (NMP) to resuscitate moderately steatotic livers for transplantation in patients. This will be a single-site clinical trial placing donor livers with 30-60% macrosteatosis on NMP, and then transplanting those that meet commonly accepted viability criteria. The results of this study could lead to a trial extending NMP transplantation to severely steatotic livers, further expanding the donor organ pool.

Official Title

Normothermic Machine Perfusion of Steatotic Livers for Expansion of Donor Organ Pool

Quick Facts

Study Start:2024-02-28
Study Completion:2026-11
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06088758

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 80 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Age 18-80 years
  2. * Listed for liver transplantation at MGH
  3. * Calculated MELD-Na score \<= 25
  4. * Able to consent
  1. * Status 1a
  2. * Cardiac or pulmonary disease
  3. * Prior liver transplant
  4. * Requiring pressors at the time of liver offer
  5. * MELD\<15 and asymptomatic from liver disease

Contacts and Locations

Study Contact

Heidi Yeh, MD
CONTACT
617-643-4533
hyeh@mgh.harvard.edu

Study Locations (Sites)

Massachusetts General Brigham
Boston, Massachusetts, 02114
United States

Collaborators and Investigators

Sponsor: Massachusetts General Hospital

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2024-02-28
Study Completion Date2026-11

Study Record Updates

Study Start Date2024-02-28
Study Completion Date2026-11

Terms related to this study

Additional Relevant MeSH Terms

  • Liver Transplant