ACTIVE_NOT_RECRUITING

The PLATINUM Trial: Optimizing Chemotherapy for the Second-Line Treatment of Metastatic BRCA1/2 or PALB2-Associated Metastatic Pancreatic Cancer

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Conditions

Pancreatic Acinar Cell CarcinomaPancreatic AdenocarcinomaPancreatic Adenosquamous CarcinomaPancreatic CarcinomaPancreatic Ductal AdenocarcinomaPancreatic Squamous Cell CarcinomaStage IV Pancreatic Cancer AJCC v8

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

This phase II/III trial compares the effect of the 3-drug chemotherapy combination of nab-paclitaxel, gemcitabine, plus cisplatin versus the 2-drug chemotherapy combination of nab-paclitaxel plus gemcitabine for the treatment of patients with pancreatic cancer that has spread to other places in the body (metastatic) and a known genetic mutation in the BRCA1, BRCA2, or PALB2 gene.

Official Title

Phase II/III Second-Line NABPLAGEM vs. Nab-Paclitaxel/Gemcitabine in BRCA1/2 or PALB2 Mutant Metastatic Pancreatic Ductal Adenocarcinoma (PLATINUM)

Quick Facts

Study Start:2024-08-13
Study Completion:2029-12-09
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:ACTIVE_NOT_RECRUITING

Study ID

NCT06115499

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Metastatic pancreatic adenocarcinoma. Adenosquamous carcinoma, squamous carcinoma, acinar cell carcinoma, and carcinoma not otherwise specified are also acceptable
  2. * BRCA1/2 or PALB2 mutation (somatic or germline) identified on any Clinical Laboratory Improvement Amendments (CLIA)-certified gene panel. Mutations must be considered pathogenic or likely pathogenic by a reference database such as ClinVar or OncoKb.org. (Submission of mutation report will be required)
  3. * Measurable disease
  4. * Potential trial participants should have recovered from clinically significant adverse events of their most recent therapy/intervention prior to enrollment
  5. * Clinical or radiographic progression on first-line FOLFIRINOX (or nanoliposomal irinotecan, fluorouracil, leucovorin, and oxaliplatin \[NALIRIFOX\]) for metastatic disease
  6. * Patients whose front-line chemotherapy was required to be simplified due to toxicity associated with any of the constituent components of FOLFIRINOX/NALIRIFOX (e.g. simplified to leucovorin calcium, fluorouracil, and oxaliplatin \[FOLFOX\], leucovorin calcium, fluorouracil, and irinotecan \[FOLFIRI\], fluorouracil \[5-FU\] \[including capecitabine\]) will be eligible
  7. * Patients with progressive disease while on maintenance PARP inhibitor treatment after FOLFIRINOX (or NALIRIFOX), irrespective of how long ago they received FOLFIRINOX/NALIRIFOX, will also be eligible
  8. * Patients who develop metastatic disease during or within 6 months after completing FOLFIRINOX/NALIRIFOX in either the locally advanced or adjuvant/neoadjuvant settings will be eligible
  9. * Patients may not have received prior cisplatin for their pancreatic cancer in any setting
  10. * Age \>= 18 years
  11. * Eastern Cooperative Oncology Group (ECOG) performance status 0-2 (Karnofsky performance status \>= 60)
  12. * Absolute neutrophil count \>= 1,500/mm\^3
  13. * Platelet count \>= 100,000/mm\^3
  14. * Hemoglobin \>= 8.0 g/dL
  15. * Creatinine =\< 1.8 x institutional upper limit of normal (ULN) or calculated creatinine clearance (Calc. CrCl) \> 40 mL/min
  16. * Total bilirubin =\< 2.0 x institutional ULN
  17. * Aspartate transaminase (AST)/alanine transaminase (ALT) =\< 3 x institutional ULN
  18. * Not pregnant and not nursing, because this study involves an agent that has known genotoxic, mutagenic and teratogenic effects
  19. * Patients with \> grade 2 peripheral sensory neuropathy are not eligible
  20. * Patients with a prior or concurrent malignancy whose natural history or treatment does not have the potential to interfere with the safety or efficacy assessment of the investigational regimen are eligible for this trial
  21. * Patients with treated brain metastases are eligible if follow-up brain imaging after central nervous system (CNS)-directed therapy shows no evidence of progression for at least 8-weeks.
  22. * Human immunodeficiency virus (HIV)-infected patients on effective anti-retroviral therapy with undetectable viral load anytime within 6 months prior to registration are eligible for this trial
  23. * For patients with evidence of chronic hepatitis B virus (HBV) infection, the HBV viral load must be undetectable on suppressive therapy, if indicated.
  24. * Concomitant chronic concomitant treatment with strong inhibitors of CYP3A4 is not allowed on this study. Patients on strong CYP3A4 inhibitors must discontinue the drug for 14 days prior to registration on the study
  25. * Chronic concomitant treatment with strong CYP3A4 inducers is not allowed. Patients must discontinue the drug 14 days prior to the start of study treatment
  1. * N/A

Contacts and Locations

Study Locations (Sites)

Anchorage Associates in Radiation Medicine
Anchorage, Alaska, 98508
United States
Anchorage Radiation Therapy Center
Anchorage, Alaska, 99504
United States
Alaska Breast Care and Surgery LLC
Anchorage, Alaska, 99508
United States
Alaska Oncology and Hematology LLC
Anchorage, Alaska, 99508
United States
Alaska Women's Cancer Care
Anchorage, Alaska, 99508
United States
Anchorage Oncology Centre
Anchorage, Alaska, 99508
United States
Katmai Oncology Group
Anchorage, Alaska, 99508
United States
Providence Alaska Medical Center
Anchorage, Alaska, 99508
United States
CTCA at Western Regional Medical Center
Goodyear, Arizona, 85338
United States
Cancer Center at Saint Joseph's
Phoenix, Arizona, 85004
United States
NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro
Jonesboro, Arkansas, 72401
United States
Mission Hope Medical Oncology - Arroyo Grande
Arroyo Grande, California, 93420
United States
Providence Saint Joseph Medical Center/Disney Family Cancer Center
Burbank, California, 91505
United States
Mercy Cancer Center - Carmichael
Carmichael, California, 95608
United States
Mercy San Juan Medical Center
Carmichael, California, 95608
United States
Mercy Cancer Center - Elk Grove
Elk Grove, California, 95758
United States
UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care
Irvine, California, 92612
United States
UC San Diego Moores Cancer Center
La Jolla, California, 92093
United States
UCI Health Laguna Hills
Laguna Hills, California, 92653
United States
Mercy Cancer Center
Merced, California, 95340
United States
Providence Queen of The Valley
Napa, California, 94558
United States
UC Irvine Health/Chao Family Comprehensive Cancer Center
Orange, California, 92868
United States
Mercy Cancer Center - Rocklin
Rocklin, California, 95765
United States
Mercy Cancer Center - Sacramento
Sacramento, California, 95816
United States
UC San Diego Medical Center - Hillcrest
San Diego, California, 92103
United States
UCSF Medical Center-Mission Bay
San Francisco, California, 94158
United States
Pacific Central Coast Health Center-San Luis Obispo
San Luis Obispo, California, 93401
United States
Mission Hope Medical Oncology - Santa Maria
Santa Maria, California, 93444
United States
Providence Medical Foundation - Santa Rosa
Santa Rosa, California, 95403
United States
Providence Santa Rosa Memorial Hospital
Santa Rosa, California, 95405
United States
Saint Joseph's Medical Center
Stockton, California, 95204
United States
Woodland Memorial Hospital
Woodland, California, 95695
United States
Penrose-Saint Francis Healthcare
Colorado Springs, Colorado, 80907
United States
Rocky Mountain Cancer Centers-Penrose
Colorado Springs, Colorado, 80907
United States
Saint Francis Cancer Center
Colorado Springs, Colorado, 80923
United States
CommonSpirit Cancer Center Mercy
Durango, Colorado, 81301
United States
Mercy Medical Center
Durango, Colorado, 81301
United States
Saint Anthony Hospital
Lakewood, Colorado, 80228
United States
Longmont United Hospital
Longmont, Colorado, 80501
United States
Saint Mary Corwin Medical Center
Pueblo, Colorado, 81004
United States
Saint Anthony North Hospital
Westminster, Colorado, 80023
United States
Mount Sinai Comprehensive Cancer Center at Aventura
Aventura, Florida, 33180
United States
Mount Sinai Medical Center
Miami Beach, Florida, 33140
United States
University Cancer and Blood Center LLC
Athens, Georgia, 30607
United States
Hawaii Cancer Care Inc - Waterfront Plaza
Honolulu, Hawaii, 96813
United States
Queen's Cancer Cenrer - POB I
Honolulu, Hawaii, 96813
United States
Queen's Medical Center
Honolulu, Hawaii, 96813
United States
Straub Clinic and Hospital
Honolulu, Hawaii, 96813
United States
University of Hawaii Cancer Center
Honolulu, Hawaii, 96813
United States
Hawaii Diagnostic Radiology Services LLC
Honolulu, Hawaii, 96817
United States
Kuakini Medical Center
Honolulu, Hawaii, 96817
United States
Queen's Cancer Center - Kuakini
Honolulu, Hawaii, 96817
United States
The Cancer Center of Hawaii-Liliha
Honolulu, Hawaii, 96817
United States
Kapiolani Medical Center for Women and Children
Honolulu, Hawaii, 96826
United States
Straub Medical Center - Kahului Clinic
Kahului, Hawaii, 96732
United States
Castle Medical Center
Kailua, Hawaii, 96734
United States
Wilcox Memorial Hospital and Kauai Medical Clinic
Lihue, Hawaii, 96766
United States
Hawaii Cancer Care - Westridge
‘Aiea, Hawaii, 96701
United States
Pali Momi Medical Center
‘Aiea, Hawaii, 96701
United States
Queen's Cancer Center - Pearlridge
‘Aiea, Hawaii, 96701
United States
The Cancer Center of Hawaii-Pali Momi
‘Aiea, Hawaii, 96701
United States
The Queen's Medical Center - West Oahu
‘Ewa Beach, Hawaii, 96706
United States
Saint Alphonsus Cancer Care Center-Boise
Boise, Idaho, 83706
United States
Saint Luke's Cancer Institute - Boise
Boise, Idaho, 83712
United States
Saint Alphonsus Cancer Care Center-Caldwell
Caldwell, Idaho, 83605
United States
Kootenai Health - Coeur d'Alene
Coeur d'Alene, Idaho, 83814
United States
Walter Knox Memorial Hospital
Emmett, Idaho, 83617
United States
Saint Luke's Cancer Institute - Fruitland
Fruitland, Idaho, 83619
United States
Idaho Urologic Institute-Meridian
Meridian, Idaho, 83642
United States
Saint Luke's Cancer Institute - Meridian
Meridian, Idaho, 83642
United States
Saint Alphonsus Cancer Care Center-Nampa
Nampa, Idaho, 83687
United States
Saint Luke's Cancer Institute - Nampa
Nampa, Idaho, 83687
United States
Kootenai Clinic Cancer Services - Post Falls
Post Falls, Idaho, 83854
United States
Kootenai Clinic Cancer Services - Sandpoint
Sandpoint, Idaho, 83864
United States
Saint Luke's Cancer Institute - Twin Falls
Twin Falls, Idaho, 83301
United States
Rush-Copley Medical Center
Aurora, Illinois, 60504
United States
Illinois CancerCare-Bloomington
Bloomington, Illinois, 61704
United States
Illinois CancerCare-Canton
Canton, Illinois, 61520
United States
Memorial Hospital of Carbondale
Carbondale, Illinois, 62902
United States
SIH Cancer Institute
Carterville, Illinois, 62918
United States
Illinois CancerCare-Carthage
Carthage, Illinois, 62321
United States
Centralia Oncology Clinic
Centralia, Illinois, 62801
United States
Northwestern University
Chicago, Illinois, 60611
United States
University of Illinois
Chicago, Illinois, 60612
United States
University of Chicago Comprehensive Cancer Center
Chicago, Illinois, 60637
United States
Carle at The Riverfront
Danville, Illinois, 61832
United States
Cancer Care Specialists of Illinois - Decatur
Decatur, Illinois, 62526
United States
Decatur Memorial Hospital
Decatur, Illinois, 62526
United States
Northwestern Medicine Cancer Center Kishwaukee
DeKalb, Illinois, 60115
United States
Illinois CancerCare-Dixon
Dixon, Illinois, 61021
United States
Carle Physician Group-Effingham
Effingham, Illinois, 62401
United States
Crossroads Cancer Center
Effingham, Illinois, 62401
United States
Illinois CancerCare-Eureka
Eureka, Illinois, 61530
United States
Illinois CancerCare-Galesburg
Galesburg, Illinois, 61401
United States
Western Illinois Cancer Treatment Center
Galesburg, Illinois, 61401
United States
Northwestern Medicine Cancer Center Delnor
Geneva, Illinois, 60134
United States
Northwestern Medicine Glenview Outpatient Center
Glenview, Illinois, 60026
United States
Northwestern Medicine Grayslake Outpatient Center
Grayslake, Illinois, 60030
United States
Ingalls Memorial Hospital
Harvey, Illinois, 60426
United States
Illinois CancerCare-Kewanee Clinic
Kewanee, Illinois, 61443
United States
Northwestern Medicine Lake Forest Hospital
Lake Forest, Illinois, 60045
United States
Illinois CancerCare-Macomb
Macomb, Illinois, 61455
United States
Carle Physician Group-Mattoon/Charleston
Mattoon, Illinois, 61938
United States
UC Comprehensive Cancer Center at Silver Cross
New Lenox, Illinois, 60451
United States
Cancer Care Center of O'Fallon
O'Fallon, Illinois, 62269
United States
HSHS Saint Elizabeth's Hospital
O'Fallon, Illinois, 62269
United States
Northwestern Medicine Oak Brook
Oak Brook, Illinois, 60523
United States
Northwestern Medicine Orland Park
Orland Park, Illinois, 60462
United States
University of Chicago Medicine-Orland Park
Orland Park, Illinois, 60462
United States
Illinois CancerCare-Ottawa Clinic
Ottawa, Illinois, 61350
United States
Illinois CancerCare-Pekin
Pekin, Illinois, 61554
United States
Illinois CancerCare-Peoria
Peoria, Illinois, 61615
United States
Methodist Medical Center of Illinois
Peoria, Illinois, 61636
United States
Illinois CancerCare-Peru
Peru, Illinois, 61354
United States
Valley Radiation Oncology
Peru, Illinois, 61354
United States
Illinois CancerCare-Princeton
Princeton, Illinois, 61356
United States
Southern Illinois University School of Medicine
Springfield, Illinois, 62702
United States
Springfield Clinic
Springfield, Illinois, 62702
United States
Springfield Memorial Hospital
Springfield, Illinois, 62781
United States
Carle Cancer Center
Urbana, Illinois, 61801
United States
Northwestern Medicine Cancer Center Warrenville
Warrenville, Illinois, 60555
United States
Illinois CancerCare - Washington
Washington, Illinois, 61571
United States
Rush-Copley Healthcare Center
Yorkville, Illinois, 60560
United States
Northwest Cancer Center - Main Campus
Crown Point, Indiana, 46307
United States
UChicago Medicine Northwest Indiana
Crown Point, Indiana, 46307
United States
Northwest Oncology LLC
Dyer, Indiana, 46311
United States
Northwest Cancer Center - Hobart
Hobart, Indiana, 46342
United States
Saint Mary Medical Center
Hobart, Indiana, 46342
United States
Saint Catherine Hospital
Indianapolis, Indiana, 46312
United States
The Community Hospital
Munster, Indiana, 46321
United States
Women's Diagnostic Center - Munster
Munster, Indiana, 46321
United States
Northwest Cancer Center - Valparaiso
Valparaiso, Indiana, 46383
United States
Mary Greeley Medical Center
Ames, Iowa, 50010
United States
McFarland Clinic - Ames
Ames, Iowa, 50010
United States
UI Health Care Mission Cancer and Blood - Ankeny Clinic
Ankeny, Iowa, 50023
United States
McFarland Clinic - Boone
Boone, Iowa, 50036
United States
Mercy Hospital
Cedar Rapids, Iowa, 52403
United States
Oncology Associates at Mercy Medical Center
Cedar Rapids, Iowa, 52403
United States
Mercy Cancer Center-West Lakes
Clive, Iowa, 50325
United States
UI Health Care Mission Cancer and Blood - West Des Moines Clinic
Clive, Iowa, 50325
United States
Alegent Health Mercy Hospital
Council Bluffs, Iowa, 51503
United States
Heartland Oncology and Hematology LLP
Council Bluffs, Iowa, 51503
United States
Methodist Jennie Edmundson Hospital
Council Bluffs, Iowa, 51503
United States
Greater Regional Medical Center
Creston, Iowa, 50801
United States
Iowa Methodist Medical Center
Des Moines, Iowa, 50309
United States
UI Health Care Mission Cancer and Blood - Des Moines Clinic
Des Moines, Iowa, 50309
United States
Mercy Medical Center - Des Moines
Des Moines, Iowa, 50314
United States
UI Health Care Mission Cancer and Blood - Laurel Clinic
Des Moines, Iowa, 50314
United States
McFarland Clinic - Trinity Cancer Center
Fort Dodge, Iowa, 50501
United States
McFarland Clinic - Jefferson
Jefferson, Iowa, 50129
United States
McFarland Clinic - Marshalltown
Marshalltown, Iowa, 50158
United States
UI Health Care Mission Cancer and Blood - Waukee Clinic
Waukee, Iowa, 50263
United States
Mercy Medical Center-West Lakes
West Des Moines, Iowa, 50266
United States
Flaget Memorial Hospital
Bardstown, Kentucky, 40004
United States
Commonwealth Cancer Center-Corbin
Corbin, Kentucky, 40701
United States
Saint Joseph Hospital
Lexington, Kentucky, 40504
United States
Saint Joseph Radiation Oncology Resource Center
Lexington, Kentucky, 40504
United States
Saint Joseph Hospital East
Lexington, Kentucky, 40509
United States
Saint Joseph London
London, Kentucky, 40741
United States
Saint Joseph Mount Sterling
Mount Sterling, Kentucky, 40353
United States
Hickman Cancer Center
Adrian, Michigan, 49221
United States
University of Michigan Rogel Cancer Center
Ann Arbor, Michigan, 48109
United States
Bronson Battle Creek
Battle Creek, Michigan, 49017
United States
University of Michigan - Brighton Center for Specialty Care
Brighton, Michigan, 48116
United States
Henry Ford Cancer Institute-Downriver
Brownstown, Michigan, 48183
United States
Henry Ford Macomb Hospital-Clinton Township
Clinton Township, Michigan, 48038
United States
Henry Ford Medical Center-Fairlane
Dearborn, Michigan, 48126
United States
Henry Ford Hospital
Detroit, Michigan, 48202
United States
Corewell Health Grand Rapids Hospitals - Butterworth Hospital
Grand Rapids, Michigan, 49503
United States
Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital
Grand Rapids, Michigan, 49503
United States
Trinity Health Grand Rapids Hospital
Grand Rapids, Michigan, 49503
United States
Allegiance Health
Jackson, Michigan, 49201
United States
Bronson Methodist Hospital
Kalamazoo, Michigan, 49007
United States
West Michigan Cancer Center
Kalamazoo, Michigan, 49007
United States
Beacon Kalamazoo Cancer Center
Kalamazoo, Michigan, 49009
United States
Beacon Kalamazoo
Kalamazoo, Michigan, 49048
United States
Toledo Clinic Cancer Centers-Monroe
Monroe, Michigan, 48162
United States
Trinity Health Muskegon Hospital
Muskegon, Michigan, 49444
United States
Corewell Health Lakeland Hospitals - Niles Hospital
Niles, Michigan, 49120
United States
Cancer and Hematology Centers of Western Michigan - Norton Shores
Norton Shores, Michigan, 49444
United States
Henry Ford Medical Center-Columbus
Novi, Michigan, 48377
United States
Corewell Health Reed City Hospital
Reed City, Michigan, 49677
United States
Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center
Saint Joseph, Michigan, 49085
United States
Corewell Health Lakeland Hospitals - Saint Joseph Hospital
Saint Joseph, Michigan, 49085
United States
Munson Medical Center
Traverse City, Michigan, 49684
United States
Henry Ford West Bloomfield Hospital
West Bloomfield, Michigan, 48322
United States
Henry Ford Wyandotte Hospital
Wyandotte, Michigan, 48192
United States
University of Michigan Health - West
Wyoming, Michigan, 49519
United States
Riverwood Healthcare Center
Aitkin, Minnesota, 56431
United States
Essentia Health - Baxter Clinic
Baxter, Minnesota, 56425
United States
Essentia Health Saint Joseph's Medical Center
Brainerd, Minnesota, 56401
United States
Minnesota Oncology - Burnsville
Burnsville, Minnesota, 55337
United States
Cambridge Medical Center
Cambridge, Minnesota, 55008
United States
Mercy Hospital
Coon Rapids, Minnesota, 55433
United States
Essentia Health - Saint Joseph's Crosslake Clinic
Crosslake, Minnesota, 56442
United States
Essentia Health - Deer River Clinic
Deer River, Minnesota, 56636
United States
Essentia Health Saint Mary's - Detroit Lakes Clinic
Detroit Lakes, Minnesota, 56501
United States
Essentia Health Cancer Center
Duluth, Minnesota, 55805
United States
Essentia Health Saint Mary's Medical Center
Duluth, Minnesota, 55805
United States
Miller-Dwan Hospital
Duluth, Minnesota, 55805
United States
Fairview Southdale Hospital
Edina, Minnesota, 55435
United States
Essentia Health - Ely Clinic
Ely, Minnesota, 55731
United States
Essentia Health - Fosston
Fosston, Minnesota, 56542
United States
Essentia Health Hibbing Clinic
Hibbing, Minnesota, 55746
United States
Essentia Health - International Falls Clinic
International Falls, Minnesota, 56649
United States
Fairview Clinics and Surgery Center Maple Grove
Maple Grove, Minnesota, 55369
United States
Minnesota Oncology Hematology PA-Maplewood
Maplewood, Minnesota, 55109
United States
Saint John's Hospital - Healtheast
Maplewood, Minnesota, 55109
United States
Abbott-Northwestern Hospital
Minneapolis, Minnesota, 55407
United States
Hennepin County Medical Center
Minneapolis, Minnesota, 55415
United States
Health Partners Inc
Minneapolis, Minnesota, 55454
United States
Monticello Cancer Center
Monticello, Minnesota, 55362
United States
Essentia Health - Moose Lake Clinic
Moose Lake, Minnesota, 55767
United States
New Ulm Medical Center
New Ulm, Minnesota, 56073
United States
Essentia Health - Park Rapids
Park Rapids, Minnesota, 56470
United States
Essentia Health - Saint Joseph's Pequot Lakes Clinic
Pequot Lakes, Minnesota, 56472
United States
Essentia Health - Saint Joseph's Pine River Clinic
Pine River, Minnesota, 56474
United States
Fairview Northland Medical Center
Princeton, Minnesota, 55371
United States
North Memorial Medical Health Center
Robbinsdale, Minnesota, 55422
United States
Coborn Cancer Center at Saint Cloud Hospital
Saint Cloud, Minnesota, 56303
United States
Park Nicollet Clinic - Saint Louis Park
Saint Louis Park, Minnesota, 55416
United States
Regions Hospital
Saint Paul, Minnesota, 55101
United States
United Hospital
Saint Paul, Minnesota, 55102
United States
Essentia Health Sandstone
Sandstone, Minnesota, 55072
United States
Saint Francis Regional Medical Center
Shakopee, Minnesota, 55379
United States
Essentia Health - Saint Joseph's Staples Clinic
Staples, Minnesota, 56479
United States
Lakeview Hospital
Stillwater, Minnesota, 55082
United States
Essentia Health Virginia Clinic
Virginia, Minnesota, 55792
United States
Ridgeview Medical Center
Waconia, Minnesota, 55387
United States
Rice Memorial Hospital
Willmar, Minnesota, 56201
United States
Minnesota Oncology Hematology PA-Woodbury
Woodbury, Minnesota, 55125
United States
Fairview Lakes Medical Center
Wyoming, Minnesota, 55092
United States
Baptist Memorial Hospital and Cancer Center-Golden Triangle
Columbus, Mississippi, 39705
United States
Baptist Cancer Center-Grenada
Grenada, Mississippi, 38901
United States
Baptist Memorial Hospital and Cancer Center-Union County
New Albany, Mississippi, 38652
United States
Baptist Memorial Hospital and Cancer Center-Oxford
Oxford, Mississippi, 38655
United States
Baptist Memorial Hospital and Cancer Center-Desoto
Southhaven, Mississippi, 38671
United States
Mercy Cancer Center - Cape Girardeau
Cape Girardeau, Missouri, 63703
United States
Saint Francis Medical Center
Cape Girardeau, Missouri, 63703
United States
Parkland Health Center - Farmington
Farmington, Missouri, 63640
United States
Sainte Genevieve County Memorial Hospital
Sainte Genevieve, Missouri, 63670
United States
Missouri Baptist Medical Center
St Louis, Missouri, 63131
United States
Missouri Baptist Sullivan Hospital
Sullivan, Missouri, 63080
United States
BJC Outpatient Center at Sunset Hills
Sunset Hills, Missouri, 63127
United States
Community Hospital of Anaconda
Anaconda, Montana, 59711
United States
Billings Clinic Cancer Center
Billings, Montana, 59101
United States
Bozeman Health Deaconess Hospital
Bozeman, Montana, 59715
United States
Benefis Sletten Cancer Institute
Great Falls, Montana, 59405
United States
Great Falls Clinic
Great Falls, Montana, 59405
United States
Hi-Line Sletten Cancer Center
Havre, Montana, 59501
United States
Logan Health Medical Center
Kalispell, Montana, 59901
United States
Saint Patrick Hospital - Community Hospital
Missoula, Montana, 59802
United States
Community Medical Center
Missoula, Montana, 59804
United States
CHI Health Saint Francis
Grand Island, Nebraska, 68803
United States
CHI Health Good Samaritan
Kearney, Nebraska, 68847
United States
Saint Elizabeth Regional Medical Center
Lincoln, Nebraska, 68510
United States
Nebraska Cancer Specialists/Oncology Hematology West PC - MECC
Omaha, Nebraska, 68114
United States
Nebraska Methodist Hospital
Omaha, Nebraska, 68114
United States
Oncology Associates PC
Omaha, Nebraska, 68114
United States
Alegent Health Immanuel Medical Center
Omaha, Nebraska, 68122
United States
Alegent Health Bergan Mercy Medical Center
Omaha, Nebraska, 68124
United States
Alegent Health Lakeside Hospital
Omaha, Nebraska, 68130
United States
Creighton University Medical Center
Omaha, Nebraska, 68131
United States
Midlands Community Hospital
Papillion, Nebraska, 68046
United States
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center
Lebanon, New Hampshire, 03756
United States
Dartmouth Cancer Center - Nashua
Nashua, New Hampshire, 03063
United States
University of New Mexico Cancer Center
Albuquerque, New Mexico, 87106
United States
Glens Falls Hospital
Glens Falls, New York, 12801
United States
NYU Langone Hospital - Long Island
Mineola, New York, 11501
United States
Laura and Isaac Perlmutter Cancer Center at NYU Langone
New York, New York, 10016
United States
Essentia Health Cancer Center-South University Clinic
Fargo, North Dakota, 58103
United States
Essentia Health - Jamestown Clinic
Jamestown, North Dakota, 58401
United States
Good Samaritan Hospital - Cincinnati
Cincinnati, Ohio, 45220
United States
Bethesda North Hospital
Cincinnati, Ohio, 45242
United States
TriHealth Cancer Institute-Westside
Cincinnati, Ohio, 45247
United States
TriHealth Cancer Institute-Anderson
Cincinnati, Ohio, 45255
United States
Toledo Clinic Cancer Centers-Maumee
Maumee, Ohio, 43537
United States
Toledo Clinic Cancer Centers-Toledo
Toledo, Ohio, 43623
United States
University of Oklahoma Health Sciences Center
Oklahoma City, Oklahoma, 73104
United States
Oklahoma Cancer Specialists and Research Institute-Tulsa
Tulsa, Oklahoma, 74146
United States
Saint Alphonsus Cancer Care Center-Baker City
Baker City, Oregon, 97814
United States
Saint Charles Health System
Bend, Oregon, 97701
United States
Clackamas Radiation Oncology Center
Clackamas, Oregon, 97015
United States
Providence Cancer Institute Clackamas Clinic
Clackamas, Oregon, 97015
United States
Bay Area Hospital
Coos Bay, Oregon, 97420
United States
Providence Hood River Memorial Hospital
Hood River, Oregon, 97031
United States
Providence Newberg Medical Center
Newberg, Oregon, 97132
United States
Saint Alphonsus Cancer Care Center-Ontario
Ontario, Oregon, 97914
United States
Providence Willamette Falls Medical Center
Oregon City, Oregon, 97045
United States
Providence Portland Medical Center
Portland, Oregon, 97213
United States
Providence Saint Vincent Medical Center
Portland, Oregon, 97225
United States
Saint Charles Health System-Redmond
Redmond, Oregon, 97756
United States
Roper Hospital
Charleston, South Carolina, 29401
United States
Charleston Oncology - Roper
Charleston, South Carolina, 29403
United States
Bon Secours Saint Francis Hospital
Charleston, South Carolina, 29414
United States
Charleston Oncology - Saint Francis
Charleston, South Carolina, 29414
United States
Baptist Memorial Hospital and Cancer Center-Collierville
Collierville, Tennessee, 38017
United States
Baptist Memorial Hospital and Cancer Center-Memphis
Memphis, Tennessee, 38120
United States
Parkland Memorial Hospital
Dallas, Texas, 75235
United States
UT Southwestern Simmons Cancer Center - RedBird
Dallas, Texas, 75237
United States
UT Southwestern/Simmons Cancer Center-Dallas
Dallas, Texas, 75390
United States
UT Southwestern/Simmons Cancer Center-Fort Worth
Fort Worth, Texas, 76104
United States
UT Southwestern Clinical Center at Richardson/Plano
Richardson, Texas, 75080
United States
Dartmouth Cancer Center - North
Saint Johnsbury, Vermont, 05819
United States
Inova Schar Cancer Institute
Fairfax, Virginia, 22031
United States
Inova Fair Oaks Hospital
Fairfax, Virginia, 22033
United States
Inova Fairfax Hospital
Falls Church, Virginia, 22042
United States
Providence Regional Cancer System-Aberdeen
Aberdeen, Washington, 98520
United States
PeaceHealth Saint Joseph Medical Center
Bellingham, Washington, 98225
United States
Providence Regional Cancer System-Centralia
Centralia, Washington, 98531
United States
Swedish Cancer Institute-Edmonds
Edmonds, Washington, 98026
United States
Providence Regional Cancer Partnership
Everett, Washington, 98201
United States
Swedish Cancer Institute-Issaquah
Issaquah, Washington, 98029
United States
Kadlec Clinic Hematology and Oncology
Kennewick, Washington, 99336
United States
Providence Regional Cancer System-Lacey
Lacey, Washington, 98503
United States
PeaceHealth Saint John Medical Center
Longview, Washington, 98632
United States
Skagit Regional Health Cancer Care Center
Mount Vernon, Washington, 98274
United States
Swedish Medical Center-Ballard Campus
Seattle, Washington, 98107
United States
Swedish Medical Center-Cherry Hill
Seattle, Washington, 98122-5711
United States
Swedish Medical Center-First Hill
Seattle, Washington, 98122
United States
PeaceHealth United General Medical Center
Sedro-Woolley, Washington, 98284
United States
Providence Regional Cancer System-Shelton
Shelton, Washington, 98584
United States
Saint Michael Cancer Center
Silverdale, Washington, 98383
United States
Cancer Care Northwest - Spokane South
Spokane, Washington, 99202
United States
Cancer Care Northwest-Valley
Spokane, Washington, 99216
United States
Cancer Care Northwest-North Spokane
Spokane, Washington, 99218
United States
PeaceHealth Southwest Medical Center
Vancouver, Washington, 98664
United States
Providence Saint Mary Regional Cancer Center
Walla Walla, Washington, 99362
United States
Providence Regional Cancer System-Yelm
Yelm, Washington, 98597
United States
Duluth Clinic Ashland
Ashland, Wisconsin, 54806
United States
Northwest Wisconsin Cancer Center
Ashland, Wisconsin, 54806
United States
Marshfield Medical Center-EC Cancer Center
Eau Claire, Wisconsin, 54701
United States
Essentia Health-Hayward Clinic
Hayward, Wisconsin, 54843
United States
Tamarack Health Hayward Medical Center
Hayward, Wisconsin, 54843
United States
Marshfield Medical Center-Marshfield
Marshfield, Wisconsin, 54449
United States
Marshfield Medical Center - Minocqua
Minocqua, Wisconsin, 54548
United States
Cancer Center of Western Wisconsin
New Richmond, Wisconsin, 54017
United States
Marshfield Medical Center-Rice Lake
Rice Lake, Wisconsin, 54868
United States
Essentia Health-Spooner Clinic
Spooner, Wisconsin, 54801
United States
Marshfield Medical Center-River Region at Stevens Point
Stevens Point, Wisconsin, 54482
United States
Essentia Health Saint Mary's Hospital - Superior
Superior, Wisconsin, 54880
United States
Marshfield Medical Center - Weston
Weston, Wisconsin, 54476
United States
Memorial Hospital of Laramie County
Cheyenne, Wyoming, 82001
United States
Billings Clinic-Cody
Cody, Wyoming, 82414
United States
Welch Cancer Center
Sheridan, Wyoming, 82801
United States

Collaborators and Investigators

Sponsor: Alliance for Clinical Trials in Oncology

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2024-08-13
Study Completion Date2029-12-09

Study Record Updates

Study Start Date2024-08-13
Study Completion Date2029-12-09

Terms related to this study

Additional Relevant MeSH Terms

  • Pancreatic Acinar Cell Carcinoma
  • Pancreatic Adenocarcinoma
  • Pancreatic Adenosquamous Carcinoma
  • Pancreatic Carcinoma
  • Pancreatic Ductal Adenocarcinoma
  • Pancreatic Squamous Cell Carcinoma
  • Stage IV Pancreatic Cancer AJCC v8