RECRUITING

ARTEMIS - A Research Study to Look at How Ziltivekimab Works Compared to Placebo in People With a Heart Attack

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Conditions

Cardiovascular RiskAcute Myocardial Infarction (AMI)

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The research study is being done to see if ziltivekimab can be used to treat people who were admitted to hospital because of a heart attack. Ziltivekimab might reduce development of heart disease, thereby preventing new heart attacks or strokes. Participants will either get ziltivekimab (active medicine) or placebo (a dummy medicine which has no effect on the body). Which treatment participants get is decided by chance. The chance of getting ziltivekimab or placebo is the same. The participant will need to inject the study medicine into a flat skin surface in there stomach, thigh, or upper arm once every month. Ziltivekimab is not yet approved in any country or region in the world. It is a new medicine that doctors cannot prescribe. The study will last for about 2 years.

Official Title

ARTEMIS - Effects of Ziltivekimab Versus Placebo on Cardiovascular Outcomes in Patients With Acute Myocardial Infarction

Quick Facts

Study Start:2024-06-25
Study Completion:2026-09-03
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06118281

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. Age 18 years or older
  2. Willing and able to provide informed consent
  3. Able to understand and follow study procedures
  4. Stable medical condition
  1. Pregnancy or breastfeeding
  2. Severe psychiatric disorders
  3. Active substance abuse
  4. Unstable medical conditions
  5. Inability to comply with study requirements

Contacts and Locations

Study Contact

Novo Nordisk
CONTACT
(+1) 866-867-7178
clinicaltrials@novonordisk.com

Principal Investigator

Clinical Transparency dept. 2834
STUDY_DIRECTOR
Novo Nordisk A/S

Study Locations (Sites)

Advanced Cardiovascular, LLC
Alexander City, Alabama, 35010
United States
Birmingham VA Medical Center
Birmingham, Alabama, 35233
United States
Grandview Medical Center
Birmingham, Alabama, 35243
United States
Eastern Shore Rsrch Inst, LLC
Fairhope, Alabama, 36532
United States
Heart Center Rsrch_Hunstville
Huntsville, Alabama, 35801
United States
Mobile Heart USA Health Cardiology Clinic
Mobile, Alabama, 36606
United States
Mercy Gilbert Medical Center
Gilbert, Arizona, 85297
United States
Mayo Clinic Arizona
Phoenix, Arizona, 85054
United States
Honor Health
Scottsdale, Arizona, 85258
United States
Arkansas Cardiology Clinic
Little Rock, Arkansas, 72205
United States
Valley Clinical Trials
Covina, California, 91723
United States
Valley Clinical Trials
Covina, California, 91723
United States
Loma Linda University Faculty Medical Clinics
Loma Linda, California, 92354
United States
VA Greater Los Angeles Hlthcare System
Los Angeles, California, 90073
United States
University of Californ LA-UCLA
Los Angeles, California, 90095
United States
University Of California Irvine
Orange, California, 92868
United States
UCSD Medical Center
San Diego, California, 92103
United States
Kaiser Permanente Viewridge Medical Offices
San Diego, California, 92123
United States
San Diego Cardiac Center
San Diego, California, 92123
United States
San Francisco V.A. Medical Center
San Francisco, California, 94121
United States
LA BioMed Harbor UCLA Med Cenr
Torrance, California, 90502
United States
Torrance Memorial Medical Center
Torrance, California, 90505
United States
Interventional Cardiology Medical Group
West Hills, California, 91307
United States
University of CO - Division of Cardiology
Aurora, Colorado, 80045
United States
S Denver Cardiology Associates
Littleton, Colorado, 80120
United States
Advanced Heart & Vein Center
Thornton, Colorado, 80023
United States
Bridgeport Hospital
Bridgeport, Connecticut, 06610
United States
Danbury Hospital - Cardiology Department
Danbury, Connecticut, 06810
United States
Yale Ctr for Clin Invest
New Haven, Connecticut, 06519
United States
Cardiology Associates of Fairfield County
Stamford, Connecticut, 06905
United States
Christiana Care Health Services, Inc.
Newark, Delaware, 19718
United States
MedStar Hlth Res Institute
Washington, District of Columbia, 20010
United States
Holy Cross Hospital
Fort Lauderdale, Florida, 33308
United States
University of Florida
Gainesville, Florida, 32608
United States
Memorial Healthcare
Hollywood, Florida, 33021
United States
UF Hepatology Jacksonville
Jacksonville, Florida, 32209
United States
Mayo Clinic Jacksonville
Jacksonville, Florida, 32224
United States
Baptist Heart Specialists
Jacksonville, Florida, 32258
United States
Baptist Hospital Cardiology
Pensacola, Florida, 32503
United States
Ascension Sacred Heart
Pensacola, Florida, 32504
United States
Intercoastal Medical Group
Sarasota, Florida, 34232
United States
Winter Haven Hospital
Winter Haven, Florida, 33881
United States
Emory University Hospital
Atlanta, Georgia, 30322-1059
United States
Augusta University
Augusta, Georgia, 30912
United States
Atlanta VAMC
Decatur, Georgia, 30033
United States
Northeast Georgia Medical Ctr
Gainesville, Georgia, 30501
United States
Cardio. Consult. of S. GA
Thomasville, Georgia, 31792
United States
St. Luke's Idaho Cardiology Associates
Meridian, Idaho, 83642
United States
Endeavor Health Glenbook Hosp
Evanston, Illinois, 60201
United States
OSF HealthCare_Cardiovasc Inst
Rockford, Illinois, 61107
United States
Prairie Cardiovascular Consultants, Ltd.
Springfield, Illinois, 62701
United States
Indiana University Health Methodist Hosptial
Indianapolis, Indiana, 46202
United States
Reid Physician Associates
Richmond, Indiana, 47374
United States
University Of Kansas Hospital
Kansas City, Kansas, 66160
United States
Midwest Heart and Vascular Specialists
Overland Park, Kansas, 66211
United States
Midwest Heart and Vascular Specialists
Overland Park, Kansas, 66211
United States
Saint Elizabeth Medical Center
Edgewood, Kentucky, 41017
United States
University Of Louisville
Louisville, Kentucky, 40202
United States
University Medical Center New Orleans
New Orleans, Louisiana, 70112
United States
Overton Brooks V.A. Medical Center
Shreveport, Louisiana, 71101-4295
United States
Northern Light Eastern Maine Medical Center
Bangor, Maine, 04401
United States
Maine Medical Center Bramhall
Portland, Maine, 04102
United States
Adventist HealthCare Shady Grove Medical Center
Rockville, Maryland, 20850
United States
Jadestone Clinical Research, LLC
Silver Spring, Maryland, 20904
United States
Brigham & Women's Hospital
Boston, Massachusetts, 02115
United States
McLaren Bay Region
Bay City, Michigan, 48708
United States
Wayne State University/University Health Center
Detroit, Michigan, 48201
United States
WMU Homer Stryker MD School of Medicine
Kalamazoo, Michigan, 49008
United States
McLaren Greater Lansing
Lansing, Michigan, 48910
United States
MidMic Medical Cntr - Midland
Midland, Michigan, 48670
United States
McLaren Macomb Health Care
Mount Clemens, Michigan, 48043
United States
McLaren Northern MI Hosp
Petoskey, Michigan, 49770
United States
Corewell Health
Royal Oak, Michigan, 48073
United States
Ascension St. Mary's Research Institute - Michigan
Southfield, Michigan, 48075
United States
Trinity Health Michigan Heart
Ypsilanti, Michigan, 48197
United States
Essentia Health
Duluth, Minnesota, 55805
United States
Fairview Health Services
Maplewood, Minnesota, 55109
United States
Abbott Northwestern Hospital
Minneapolis, Minnesota, 55407
United States
Regions Hospital
Saint Paul, Minnesota, 55101
United States
Jackson Heart Clinic
Jackson, Mississippi, 39216
United States
Univ of Mississippi Med Center
Jackson, Mississippi, 39216
United States
Cardiolg Assoc Rsch LLC_Tupelo
Tupelo, Mississippi, 38801
United States
North Mississippi Medical Center
Tupelo, Mississippi, 38801
United States
North Kansas City Hospital
North Kansas City, Missouri, 64116
United States
Washington University School of Medicine_St. Louis
Saint Louis, Missouri, 63110
United States
Mercy Research
Springfield, Missouri, 65904
United States
Methodist Physicians Clinic
Omaha, Nebraska, 681114
United States
UMC of Southern Nevada
Las Vegas, Nevada, 89102
United States
Dartmouth-Hitchcock Med Ctr
Lebanon, New Hampshire, 03756
United States
Advanced Heart Care LLC
Bridgewater, New Jersey, 08807-3064
United States
Virtua Health
Camden, New Jersey, 08103
United States
Hackensack Meridian Health
Hackensack, New Jersey, 07601
United States
The Heart House Haddon Heights
Haddon Heights, New Jersey, 08035
United States
Jersey City Med Center
Jersey City, New Jersey, 07302
United States
Inspira Health
Mullica Hill, New Jersey, 08062
United States
AtlantiCare Regional Medi Cnt
Pomona, New Jersey, 08240
United States
Holy Name Medical Center
Teaneck, New Jersey, 07666
United States
Cardiovascular Associates of the Delaware Valley
Vineland, New Jersey, 08360
United States
Jacobi Medical Center
Bronx, New York, 10461
United States
Trinity Medical WNY, PC
Buffalo, New York, 14220
United States
Saint Joseph's Hospital Health Center
Liverpool, New York, 13088
United States
NYU Grossman School of Med
New York, New York, 10016
United States
The New York Hospital
New York, New York, 10021
United States
Mount Sinai Morningside
New York, New York, 10025
United States
University of Rochester
Rochester, New York, 14642
United States
St Francis Hospital Lindner Research Center
Roslyn, New York, 11576
United States
Stony Brook University Hospital
Stony Brook, New York, 11794
United States
Westchester Medical Center
Valhalla, New York, 10595
United States
Cardiology Associates_Asheville
Asheville, North Carolina, 28803
United States
UNC Hospital HVC_Meadowmont
Chapel Hill, North Carolina, 27599-7075
United States
Duke University Medical Center
Durham, North Carolina, 27710
United States
Moses H. Cone Mem Hosp
Greensboro, North Carolina, 27401
United States
Wake Forest Uni Hlth Sciences
High Point, North Carolina, 27262
United States
NC Heart and Vascular Research
Raleigh, North Carolina, 27697
United States
Novant Hlth Cardio - Kimel Park
Winston-Salem, North Carolina, 27103
United States
Sanford Health - Fargo
Fargo, North Dakota, 58102
United States
Trinity Medical Group
Minot, North Dakota, 58701
United States
Aultman Hospital
Canton, Ohio, 44710
United States
Lindner Center,Christ Hospital
Cincinnati, Ohio, 45219
United States
University of Cincinnati/UC Health
Cincinnati, Ohio, 45241
United States
University Hospitals Of Cleveland Medical Center
Cleveland, Ohio, 44106-1716
United States
Louis Stokes Clvlnd VA Med Ctr
Cleveland, Ohio, 44106
United States
MetroHealth Medical Center
Cleveland, Ohio, 44109
United States
Cleveland Clinic_Cleveland
Cleveland, Ohio, 44195
United States
Wright State University
Fairborn, Ohio, 45324
United States
Kettering Medical Center
Kettering, Ohio, 45429
United States
Mercy Health - St. Vincent Medical Center
Toledo, Ohio, 43608
United States
University of Toledo
Toledo, Ohio, 43614
United States
Genesis Health Care System
Zanesville, Ohio, 43701
United States
South Oklahoma Heart Research, LLC
Oklahoma City, Oklahoma, 73135
United States
South Oklahoma Heart Research, LLC
Oklahoma City, Oklahoma, 73135
United States
Penn State Hlth Holy Spirit Med Ctr
Camp Hill, Pennsylvania, 17001
United States
Chambersburg Hospital
Chambersburg, Pennsylvania, 17201
United States
Geisinger Medical Center
Danville, Pennsylvania, 17822
United States
Penn State Hershey Medical Center
Hershey, Pennsylvania, 17033
United States
Robert Packer Hospital
Sayre, Pennsylvania, 18840
United States
Reading Hospital
West Reading, Pennsylvania, 19611
United States
Rhode Island Hospital
Providence, Rhode Island, 02903
United States
Prism Hlth Carolina Card Cons
Greenville, South Carolina, 29605
United States
Monument Health Clinical Rsrch
Rapid City, South Dakota, 57701
United States
Sanford Research
Sioux Falls, South Dakota, 57105
United States
Chattanooga Heart Institute
Chattanooga, Tennessee, 37404
United States
Knoxville Heart Group
Knoxville, Tennessee, 37916
United States
Tennova HC Turkey Creek MC
Knoxville, Tennessee, 37934
United States
Baptist Clin Res Institute
Memphis, Tennessee, 38120
United States
Saint Thomas Hospital
Nashville, Tennessee, 37205
United States
Vanderbilt University Medical Center
Nashville, Tennessee, 37232
United States
Parkway Cardiology Associates, PC
Oak Ridge, Tennessee, 37830
United States
CV Research of Knoxville
Powell, Tennessee, 37849
United States
PharmaTex Research, LLC
Amarillo, Texas, 79106
United States
Austin Heart
Austin, Texas, 78705
United States
Liver Ins@ Mthdist DTX Med Cen
Dallas, Texas, 75203
United States
Dallas VA Medical Center
Dallas, Texas, 75216
United States
University of Texas Southwestern Medical Center
Dallas, Texas, 75390-9302
United States
University of Texas Medical Branch
Galveston, Texas, 77555
United States
Houston Medical Center
Houston, Texas, 77004
United States
Houston Methodist Hospital
Houston, Texas, 77030
United States
Texas Heart Inst Medical Ctr
Houston, Texas, 77030
United States
UT Health University of Texas
Houston, Texas, 77030
United States
Prolato Clinical Research Cntr
Houston, Texas, 77054
United States
HCA Research Institute
McAllen, Texas, 78503-1299
United States
Heart & Vascular Inst._Titus
Mount Pleasant, Texas, 75455
United States
Baylor Scott & White Res Inst
Plano, Texas, 75093
United States
Methodist Healthcare System of San Antonio
San Antonio, Texas, 78229
United States
Christus Heart and Vascular Institute
Tyler, Texas, 75701
United States
Intermountain Medical Center
Murray, Utah, 84107-5701
United States
University of Virginia
Charlottesville, Virginia, 22908
United States
Inova Fairfax Medical Campus
Falls Church, Virginia, 22042
United States
Sentara Bayside Hospital
Norfolk, Virginia, 23507
United States
Chippenham Medical Center
Richmond, Virginia, 23225
United States
Bon Secours St. Mary's Hospital of Richmond, LLC
Richmond, Virginia, 23226
United States
McGuire VA Medical Center
Richmond, Virginia, 23249
United States
Virginia Commonwealth University Health System
Richmond, Virginia, 23298
United States
VA Medical Center_Salem
Salem, Virginia, 24153-6404
United States
Valley Health Link
Winchester, Virginia, 22601
United States
Swedish Medical Center_Seattle
Seattle, Washington, 98122-5789
United States
University Of Washington_Seattle
Seattle, Washington, 98195
United States
Aurora St. Luke's Medi Ctr
Milwaukee, Wisconsin, 53215
United States

Collaborators and Investigators

Sponsor: Novo Nordisk A/S

  • Clinical Transparency dept. 2834, STUDY_DIRECTOR, Novo Nordisk A/S

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2024-06-25
Study Completion Date2026-09-03

Study Record Updates

Study Start Date2024-06-25
Study Completion Date2026-09-03

Terms related to this study

Additional Relevant MeSH Terms

  • Cardiovascular Risk
  • Acute Myocardial Infarction (AMI)