RECRUITING

Optimizing Treatment of Adhesive Small Bowel Obstruction

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

Small bowel obstruction (SBO) is one of the most common causes of serious gastrointestinal disease in the US. Adhesion-related SBO (aSBO) is usually treated by the placement of a nasogastric tube (NGT) to decompress the stomach, administration of intravenous (IV) fluids and observation by a surgical team. The purpose of this feasibility study is to determine the potential for implementation of treatment protocols for aSBO and determine the feasibility of randomizing patients with aSBO to receive or not receive NGTs or water-soluble contrast (WSC). The investigators will also determine the ability to measure HRQOL as a main outcome for the treatment of aSBO. The studies outlined in this research program intend to address gaps in knowledge about how to determine who benefits from NGT placement, who can be managed without them, how to objectively determine when a bowel obstruction has resolved, how to reintroduce feeding to patients with aSBO, what criteria should be used for hospital discharge and what role cathartics such as WSC contrast have in the management of aSBO. This feasibility study will enroll a limited number of patients (n=40) who will be followed for up to 30 days.

Official Title

The Use of Nasogastric Tubes And Water-Soluble Contrast In The Management Of Small Bowel Obstruction: A Feasibility Study

Quick Facts

Study Start:2024-01-01
Study Completion:2025-12-15
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06182319

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. 1. Male or female ≥18 years of age.
  2. 2. Documentation of aSBO as evidenced by one or more clinical features meeting the following criteria: Nausea, emesis, abdominal pain, distended abdomen CT evidence of aSBO
  1. 1. Pregnant, breastfeeding, or unwilling to practice birth control during participation in the study.
  2. 2. Presence of a condition or abnormality that in the opinion of the investigator would compromise the safety of the patient or the quality of the data.
  3. 3. Unstable angina or recent myocardial infarction (MI)/stroke within 6 months
  4. 4. Nonadhesive SBO
  5. 1. Paralytic Ileus
  6. 2. Incarcerated hernia
  7. 3. Fecal impaction
  8. 4. Intra-abdominal malignancy Early aSBO within 4 weeks of a prior abdominal operation

Contacts and Locations

Study Contact

Steven Stokes
CONTACT
310-206-7436
sstokes@mednet.ucla.edu
Edward H Livingston, MD
CONTACT
310-794-7788

Study Locations (Sites)

University of California, Los Angeles, David Geffen School of Medicine
Los Angeles, California, 90024
United States

Collaborators and Investigators

Sponsor: University of California, Los Angeles

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2024-01-01
Study Completion Date2025-12-15

Study Record Updates

Study Start Date2024-01-01
Study Completion Date2025-12-15

Terms related to this study

Keywords Provided by Researchers

  • nasogastric tube (NGT)
  • water-soluble contrast (WSC)
  • Adhesion-related SBO (aSBO)
  • Small bowel obstruction (SBO)

Additional Relevant MeSH Terms

  • Adhesive Small Bowel Obstruction