ACTIVE_NOT_RECRUITING

Plant-based Diet for Kidney Transplant Recipients

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The goal of this clinical trial is to evaluate cardiometabolic and inflammatory parameters in kidney transplant recipients after transitioning to a plant-based diet (PBD). The main aims of the study are as follows: * To test the feasibility of transiting renal allograft recipients who are \> 3 months post-transplant to a PBD * To study the effect of a PBD on cardiometabolic parameters in kidney transplant recipients * To assess the effect of a PBD on peripheral blood Th17/Treg ratio and systemic inflammation in kidney transplant recipients Participants will be asked to: * Complete a 2-week investigator-designed PBD transition program * Follow a PBD for a minimum of 16 weeks * Consent for blood draws, urine samples, and fecal samples along with physical exams * Complete intermittent food frequency questionnaires and quality of life questionnaires * Periodically meet with investigators and other study participants Researchers will compare baseline measurements with future measurements for each participant.

Official Title

Effect of Plant-based Diet on Cardiometabolic and Inflammatory Parameters in Kidney Transplant Recipients

Quick Facts

Study Start:2024-02-29
Study Completion:2026-06-01
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:ACTIVE_NOT_RECRUITING

Study ID

NCT06186843

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 80 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * \> 3 months post-kidney transplant
  2. * On style immunosuppressive medication
  3. * Without evidence of active infection/ inflammatory conditions
  4. * Estimated glomerular filtration rate \> 45ml/min/1.73 m\^2
  5. * English speaking
  6. * Reliable internet access
  1. * Acute/ chronic allograft rejection
  2. * History of non-compliance
  3. * Advance heart failure
  4. * Liver disease
  5. * Pregnancy
  6. * Malignancy
  7. * Chronic Infection
  8. * Currently following a plant-based diet

Contacts and Locations

Principal Investigator

Muralidharan Jagadeesan, MD
PRINCIPAL_INVESTIGATOR
George Washington University

Study Locations (Sites)

Transplant Institute
Washington D.C., District of Columbia, 20037
United States

Collaborators and Investigators

Sponsor: George Washington University

  • Muralidharan Jagadeesan, MD, PRINCIPAL_INVESTIGATOR, George Washington University

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2024-02-29
Study Completion Date2026-06-01

Study Record Updates

Study Start Date2024-02-29
Study Completion Date2026-06-01

Terms related to this study

Keywords Provided by Researchers

  • Kidney transplant
  • Lifestyle change
  • Plant-based diet
  • Metabolic syndrome
  • Diabetes
  • Hypertension
  • Kidney function
  • Inflammatory states

Additional Relevant MeSH Terms

  • Kidney Disease, Chronic
  • Transplant Complication
  • Hypertension
  • Diabetes Mellitus
  • Metabolic Syndrome
  • Inflammation
  • Kidney Transplant Failure
  • Dietary Habits