RECRUITING

High-Risk Metachronous Oligometastatic Prostate Cancer Trial

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The purpose of this research study is to compare the effects, good and/or bad, of using the standard of care treatment, hormonal therapy + Stereotactic Ablative Radiation (SABR) to the metastatic lesions, compared to standard of care and addition of 6-months of niraparib/abiraterone acetate combination pills and prednisone for participants with recurrent metastatic prostate cancer.

Official Title

A Randomized Trial of High-risK metachroNous oligometastatIc Prostate Cancer With hiGh-risk Mutations Treated witH meTastasiS Directed Therapy and Niraparib/Abiraterone Acetate and Prednisone (KNIGHTS)

Quick Facts

Study Start:2024-04-17

Study Completion:2029-12-31

Study Type:Not specified

Phase:Not Applicable

Enrollment:Not specified

Status:RECRUITING

Study ID

NCT06212583

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years

Sexes Eligible for Study:MALE

Accepts Healthy Volunteers:No

Standard Ages:ADULT, OLDER_ADULT

Inclusion Criteria	Exclusion Criteria
1. ≥18 years of age (or the local legal age of consent). 2. Patient must have at least one and up to three asymptomatic metastatic tumor(s) of the bone, soft tissue, or extra-pelvic nodal region each \< 5 cm or \< 250 cm3 that develop within the past 6-months that are seen on imaging. A nodal lesion is defined to include nodal conglomerates located in the same nodal chain such that they can be treated in one SABR field. Up to five lesions are allowed on advanced functional imaging such as fluciclovine (Axumin), choline or Prostate Specific Membrane Antigen (PSMA) PET-CT scan. 1. CT or MRI scan within 6 months of enrollment 2. Bone scan within 6 months of enrollment 3. Fluciclovine (Axumin), choline, or PSMA PET-CT scan within 6 months of enrollment (PET-CT scan is reasonable for study entry imaging as an alternative to CT/MRI scan and bone scan) 3. Must have a high-risk pathogenic mutation (TP53, BRCA1/2, PALB2, ATM, BRIP1, CHEK2, FANCA, RAD51B, RAD54L, MUTYH) by next generation sequencing. ATM mutation enrollment will be capped at 5% of the overall population. 4. Histologic confirmation of prostate adenocarcinoma (primary or metastatic tumor). 5. Patient may have had prior systemic therapy and/or ADT so long as testosterone is \> 100 ng/dl prior to enrollment 6. PSA \> 0.5 but \<50 at enrollment. 7. Prostate Specific Antigen Doubling Time (PSADT) \< 15 months 8. Baseline testosterone \> 100 ng/dl 9. Patient must have a life expectancy ≥ 12 months. 10. Patient must have an ECOG performance status ≤ 2. 11. Adequate hematologic, renal, and hepatic function at screening defined as follows: * Platelet count ≥100 x 109/L * Creatinine \<2 x upper limit of normal (ULN) * Serum potassium ≥3.5 mmol/L * Serum total bilirubin ≤1.5× ULN or direct bilirubin ≤1 x ULN (Note: In participants with Gilbert's syndrome, if total bilirubin is \>1.5 × ULN, measure direct and indirect bilirubin, and if direct bilirubin is ≤1.5 × ULN, participant may be eligible) * AST or ALT ≤3 × ULN 12. Patient must have the ability to understand and the willingness to sign a written informed consent document 13. Able to swallow the study medication tablets whole. 14. While on study medication and for 4 months following the last dose of study medication, a male participant must agree to use condom and an adequate contraception method for female partner (WOCBP) A male participant must agree not to donate sperm while on study treatment and for a minimum of 4 months following the last dose of study medication. 1. Castration-resistant prostate cancer (CRPC). 2. Prior radiation therapy to an overlapping site of a target lesion that would preclude further radiation therapy 3. Spinal cord compression or impending spinal cord compression. 4. Suspected intracranial and/or liver metastases (\>10 mm in largest axis). 5. Patient receiving any other investigational agents. 6. Inability to receive any form of systemic therapy in the opinion of a treating medical oncologist. 7. Unable to lie flat during or tolerate PET/MRI, PET/CT or SABR. 8. Radiographical evidence of cranial parenchymal metastasis. 9. Active second primary malignancy; AML/MDS in medical history. 10. Uncontrolled hypertension and myocardial infarction/PE/cardiac failure in last 6 months. 11. Prior treatment with PARP inhibitor 12. Refusal to sign informed consent. 13. Pathological finding consistent with small cell or neuroendocrine carcinoma of the prostate. 14. History of adrenal dysfunction 15. Long-term use of systemically administered corticosteroids (\>5mg of prednisone or the equivalent) during the study is not allowed. Short-term use (≤4 weeks, including taper) and locally administered steroids (eg, inhaled, topical, ophthalmic, and intra-articular) are allowed, if clinically indicated. 16. Active malignancies (ie, progressing or requiring treatment change in the last 24 months) other than the disease being treated under study. The only allowed exceptions are: * non-muscle invasive bladder cancer. * skin cancer (non-melanoma or melanoma) treated within the last 24 months that is considered completely cured. * malignancy that is considered cured with minimal risk of recurrence. * History or current diagnosis of MDS/AML. 17. Current evidence within 6 months prior to randomization of any of the following: 18. Presence of sustained uncontrolled hypertension (systolic blood pressure \>160 mm Hg or diastolic blood pressure \>100 mm Hg). Participants with a history of hypertension are allowed, provided that blood pressure is controlled to within these limits by an antihypertensive treatment. 19. Known allergies, hypersensitivity, or intolerance to the excipients of niraparib/abiraterone acetate tablets 20. Current evidence of any medical condition that would make prednisone use contraindicated. 21. Received an investigational intervention (including investigational vaccines) or used an invasive investigational medical device within 30 days before the planned first dose of study medication. 22. Participants who have had the following ≤28 days prior to randomization: 23. Human immunodeficiency virus positive participants with 1 or more of the following: * Receiving antiretroviral therapy that may interfere with the study medication * CD4 count \<350 at screening. * An acquired immunodeficiency syndrome-defining opportunistic infection within 6 months of the start of screening. * Human immunodeficiency virus load \>400 copies/mL 24. Active or symptomatic viral hepatitis or chronic liver disease; encephalopathy, ascites or bleeding disorders secondary to hepatic dysfunction. 25. Moderate or severe hepatic impairment (Class B and C per Child-Pugh classification system.	Pregnancy or breastfeeding Severe psychiatric disorders Active substance abuse Unstable medical conditions Inability to comply with study requirements

Inclusion Criteria

Exclusion Criteria

1. ≥18 years of age (or the local legal age of consent).
2. Patient must have at least one and up to three asymptomatic metastatic tumor(s) of the bone, soft tissue, or extra-pelvic nodal region each \< 5 cm or \< 250 cm3 that develop within the past 6-months that are seen on imaging. A nodal lesion is defined to include nodal conglomerates located in the same nodal chain such that they can be treated in one SABR field. Up to five lesions are allowed on advanced functional imaging such as fluciclovine (Axumin), choline or Prostate Specific Membrane Antigen (PSMA) PET-CT scan.
1. CT or MRI scan within 6 months of enrollment
2. Bone scan within 6 months of enrollment
3. Fluciclovine (Axumin), choline, or PSMA PET-CT scan within 6 months of enrollment (PET-CT scan is reasonable for study entry imaging as an alternative to CT/MRI scan and bone scan)
3. Must have a high-risk pathogenic mutation (TP53, BRCA1/2, PALB2, ATM, BRIP1, CHEK2, FANCA, RAD51B, RAD54L, MUTYH) by next generation sequencing. ATM mutation enrollment will be capped at 5% of the overall population.
4. Histologic confirmation of prostate adenocarcinoma (primary or metastatic tumor).
5. Patient may have had prior systemic therapy and/or ADT so long as testosterone is \> 100 ng/dl prior to enrollment
6. PSA \> 0.5 but \<50 at enrollment.
7. Prostate Specific Antigen Doubling Time (PSADT) \< 15 months
8. Baseline testosterone \> 100 ng/dl
9. Patient must have a life expectancy ≥ 12 months.
10. Patient must have an ECOG performance status ≤ 2.
11. Adequate hematologic, renal, and hepatic function at screening defined as follows:
* Platelet count ≥100 x 109/L
* Creatinine \<2 x upper limit of normal (ULN)
* Serum potassium ≥3.5 mmol/L
* Serum total bilirubin ≤1.5× ULN or direct bilirubin ≤1 x ULN (Note: In participants with Gilbert's syndrome, if total bilirubin is \>1.5 × ULN, measure direct and indirect bilirubin, and if direct bilirubin is ≤1.5 × ULN, participant may be eligible)
* AST or ALT ≤3 × ULN
12. Patient must have the ability to understand and the willingness to sign a written informed consent document
13. Able to swallow the study medication tablets whole.
14. While on study medication and for 4 months following the last dose of study medication, a male participant must agree to use condom and an adequate contraception method for female partner (WOCBP) A male participant must agree not to donate sperm while on study treatment and for a minimum of 4 months following the last dose of study medication.
1. Castration-resistant prostate cancer (CRPC).
2. Prior radiation therapy to an overlapping site of a target lesion that would preclude further radiation therapy
3. Spinal cord compression or impending spinal cord compression.
4. Suspected intracranial and/or liver metastases (\>10 mm in largest axis).
5. Patient receiving any other investigational agents.
6. Inability to receive any form of systemic therapy in the opinion of a treating medical oncologist.
7. Unable to lie flat during or tolerate PET/MRI, PET/CT or SABR.
8. Radiographical evidence of cranial parenchymal metastasis.
9. Active second primary malignancy; AML/MDS in medical history.
10. Uncontrolled hypertension and myocardial infarction/PE/cardiac failure in last 6 months.
11. Prior treatment with PARP inhibitor
12. Refusal to sign informed consent.
13. Pathological finding consistent with small cell or neuroendocrine carcinoma of the prostate.
14. History of adrenal dysfunction
15. Long-term use of systemically administered corticosteroids (\>5mg of prednisone or the equivalent) during the study is not allowed. Short-term use (≤4 weeks, including taper) and locally administered steroids (eg, inhaled, topical, ophthalmic, and intra-articular) are allowed, if clinically indicated.
16. Active malignancies (ie, progressing or requiring treatment change in the last 24 months) other than the disease being treated under study. The only allowed exceptions are:
* non-muscle invasive bladder cancer.
* skin cancer (non-melanoma or melanoma) treated within the last 24 months that is considered completely cured.
* malignancy that is considered cured with minimal risk of recurrence.
* History or current diagnosis of MDS/AML.
17. Current evidence within 6 months prior to randomization of any of the following:
18. Presence of sustained uncontrolled hypertension (systolic blood pressure \>160 mm Hg or diastolic blood pressure \>100 mm Hg). Participants with a history of hypertension are allowed, provided that blood pressure is controlled to within these limits by an antihypertensive treatment.
19. Known allergies, hypersensitivity, or intolerance to the excipients of niraparib/abiraterone acetate tablets
20. Current evidence of any medical condition that would make prednisone use contraindicated.
21. Received an investigational intervention (including investigational vaccines) or used an invasive investigational medical device within 30 days before the planned first dose of study medication.
22. Participants who have had the following ≤28 days prior to randomization:
23. Human immunodeficiency virus positive participants with 1 or more of the following:
* Receiving antiretroviral therapy that may interfere with the study medication
* CD4 count \<350 at screening.
* An acquired immunodeficiency syndrome-defining opportunistic infection within 6 months of the start of screening.
* Human immunodeficiency virus load \>400 copies/mL
24. Active or symptomatic viral hepatitis or chronic liver disease; encephalopathy, ascites or bleeding disorders secondary to hepatic dysfunction.
25. Moderate or severe hepatic impairment (Class B and C per Child-Pugh classification system.

Pregnancy or breastfeeding
Severe psychiatric disorders
Active substance abuse
Unstable medical conditions
Inability to comply with study requirements

Contacts and Locations

Study Contact

Phuoc Tran, MD

CONTACT

410-328-6080

phuoc.tran@umm.edu

Caitlin Eggleston

CONTACT

410-328-7586

caitlineggleston@umm.edu

Study Locations (Sites)

University of Maryland Greenebaum Cancer Center

Baltimore, Maryland, 21201

United States

Collaborators and Investigators

Sponsor: University of Maryland, Baltimore

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2024-04-17

Study Completion Date2029-12-31

Study Record Updates

Study Start Date2024-04-17

Study Completion Date2029-12-31

Terms related to this study

Additional Relevant MeSH Terms

Prostate Cancer
Oligometastatic Disease