RECRUITING

Dynamics of Colonization and Infection by Multidrug-Resistant Pathogens in Immunocompromised and Critically Ill Patients

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The goal of this observational study is to investigate how bacterial populations from the intestine and mouth of patients change during the hospitalization period and evaluate if some populations of specific bacteria increase or decrease the risk of acquiring an infection or becoming colonized by pathogenic bacteria. Participants will have the following samples collected during enrollment: stool samples (maximum 2x/week), blood draws (1x/week), oral swab (1x/week).

Official Title

Dynamics of Colonization and Infection by Multidrug-Resistant Pathogens in Immunocompromised and Critically Ill Patients

Quick Facts

Study Start:2020-12-08
Study Completion:2026-06
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06258551

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Admission to an intensive care unit or stem cell transplant unit (for allogeneic stem cell transplantation) within previous 24 hours
  1. * \<18 years of age
  2. * Pregnancy
  3. * History of inflammatory bowel disease (Crohn's disease, ulcerative colitis)
  4. * Gastrointestinal derivation (colostomy, ileostomy, etc.)

Contacts and Locations

Study Contact

Cesar A Arias, MD, PhD, Msc
CONTACT
346-238-4870
CAArias@Houstonmethodist.org

Principal Investigator

Cesar A Arias, MD, PhD, Msc
PRINCIPAL_INVESTIGATOR
The Methodist Hospital Research Institute

Study Locations (Sites)

Houston Methodist Hospital
Houston, Texas, 77030
United States
The University of Texas MD Anderson Cancer Center
Houston, Texas, 77030
United States

Collaborators and Investigators

Sponsor: The Methodist Hospital Research Institute

  • Cesar A Arias, MD, PhD, Msc, PRINCIPAL_INVESTIGATOR, The Methodist Hospital Research Institute

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2020-12-08
Study Completion Date2026-06

Study Record Updates

Study Start Date2020-12-08
Study Completion Date2026-06

Terms related to this study

Additional Relevant MeSH Terms

  • Antimicrobial Drug Resistance
  • Antibiotic Resistant Infection
  • Clostridium Difficile
  • Carbapenem-Resistant Enterobacteriaceae Infection
  • Extended Spectrum Beta-Lactamase Producing Bacteria Infection
  • Vancomycin Resistant Enterococci Infection
  • Carbapenem Resistant Bacterial Infection
  • Vancomycin-Resistant Enterococcal Infection