ACTIVE_NOT_RECRUITING

Study to Evaluate the Efficacy, Safety, and Tolerability of an Anti-MTBR Tau Monoclonal Antibody (BMS-986446) in Participants With Early Alzheimer's Disease

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Conditions

Alzheimer Disease, Early OnsetAlzheimer DiseaseBMS-986446Neurodegenerative diseaseDementiaBrain DiseasesAnti-MTBR tau monoclonal antibodyTargetTau-1Anti-tau therapy

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The purpose of this study is to assess the effectiveness, safety, and tolerability of BMS-986446 an Anti-MTBR Tau Monoclonal Antibody in participants with Early Alzheimer's Disease.

Official Title

A Randomized, Double-blind, Placebo-controlled, Global Proof-of-concept Study to Evaluate the Efficacy, Safety, and Tolerability of BMS-986446, an Anti-MTBR Tau Monoclonal Antibody, in Participants With Early Alzheimer's Disease (TargetTau-1)

Quick Facts

Study Start:2024-03-20
Study Completion:2027-03-18
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:ACTIVE_NOT_RECRUITING

Study ID

NCT06268886

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:50 Years to 80 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. Age 18 years or older
  2. Willing and able to provide informed consent
  3. Able to understand and follow study procedures
  4. Stable medical condition
  1. Pregnancy or breastfeeding
  2. Severe psychiatric disorders
  3. Active substance abuse
  4. Unstable medical conditions
  5. Inability to comply with study requirements

Contacts and Locations

Principal Investigator

Bristol-Myers Squibb
STUDY_DIRECTOR
Bristol-Myers Squibb

Study Locations (Sites)

Local Institution - 0068
Chandler, Arizona, 85226-3732
United States
Local Institution - 0102
Gilbert, Arizona, 85297-0441
United States
Local Institution - 0019
Phoenix, Arizona, 85004
United States
Local Institution - 0018
Scottsdale, Arizona, 85253
United States
Local Institution - 0026
Scottsdale, Arizona, 85258-4595
United States
Local Institution - 0077
Tucson, Arizona, 85718-6522
United States
Local Institution - 0038
Tucson, Arizona, 85718-6632
United States
Local Institution - 0164
Encino, California, 91316-1511
United States
Local Institution - 0139
Fullerton, California, 92835-1040
United States
Local Institution - 0191
Irvine, California, 92614-9403
United States
Local Institution - 0234
Long Beach, California, 90804-2128
United States
Local Institution - 0142
Los Alamitos, California, 90720-3589
United States
Local Institution - 0037
Napa, California, 94558-2415
United States
Local Institution - 0209
Sacramento, California, 95816
United States
Local Institution - 0052
San Francisco, California, 94143-2350
United States
Local Institution - 0137
Santa Ana, California, 92705-8675
United States
Local Institution - 0046
Sherman Oaks, California, 91403-2131
United States
Local Institution - 0106
Danbury, Connecticut, 06810-4088
United States
Local Institution - 0148
New Haven, Connecticut, 06510
United States
Local Institution - 0056
New Haven, Connecticut, 06511-5249
United States
Local Institution - 0153
Stamford, Connecticut, 06905-1206
United States
Local Institution - 0022
Altamonte Springs, Florida, 32714-2436
United States
Local Institution - 0048
Atlantis, Florida, 33462-6631
United States
Local Institution - 0228
Boca Raton, Florida, 33428-2236
United States
Local Institution - 0250
Boca Raton, Florida, 33487-3626
United States
Local Institution - 0224
Bradenton, Florida, 34205
United States
Local Institution - 0020
Clermont, Florida, 34711-5933
United States
Local Institution - 0009
Daytona Beach, Florida, 32117-5532
United States
Local Institution - 0213
Fort Myers, Florida, 33912-4302
United States
Local Institution - 0059
Greenacres City, Florida, 33467
United States
Local Institution - 0207
Hialeah, Florida, 33012-4170
United States
Local Institution - 0212
Hialeah, Florida, 33015-5110
United States
Local Institution - 0198
Hialeah, Florida, 33016-1814
United States
Local Institution - 0151
Lady Lake, Florida, 32159
United States
Local Institution - 0146
Lakeland, Florida, 33805-2208
United States
Local Institution - 0192
Maitland, Florida, 32751-3320
United States
Local Institution - 0143
Maitland, Florida, 32751
United States
Local Institution - 0027
Merritt Island, Florida, 32952-3616
United States
Local Institution - 0197
Miami Springs, Florida, 33166-7225
United States
Local Institution - 0203
Miami, Florida, 33032
United States
Local Institution - 0058
Miami, Florida, 33122-1335
United States
Local Institution - 0034
Miami, Florida, 33125-4719
United States
Local Institution - 0211
Miami, Florida, 33126
United States
Local Institution - 0195
Miami, Florida, 33133-4231
United States
Local Institution - 0014
Miami, Florida, 33135-2957
United States
Local Institution - 0005
Miami, Florida, 33135-2968
United States
Local Institution - 0208
Miami, Florida, 33135-4759
United States
Local Institution - 0013
Miami, Florida, 33135
United States
Local Institution - 0008
Miami, Florida, 33137-2706
United States
Local Institution - 0199
Miami, Florida, 33144
United States
Local Institution - 0206
Miami, Florida, 33155-4630
United States
Local Institution - 0176
Miami, Florida, 33155-6540
United States
Local Institution - 0071
Miami, Florida, 33166-2710
United States
Local Institution - 0156
Miami, Florida, 33175-3598
United States
Local Institution - 0249
Miami, Florida, 33176-2151
United States
Local Institution - 0039
Miami, Florida, 33176-7947
United States
Local Institution - 0225
Miami, Florida, 33176
United States
Local Institution - 0217
Naples, Florida, 34105
United States
Local Institution - 0017
New Port Richey, Florida, 34652-4020
United States
Local Institution - 0144
Ocala, Florida, 34471
United States
Local Institution - 0202
Orlando, Florida, 32806-8521
United States
Local Institution - 0219
Orlando, Florida, 32807
United States
Local Institution - 0035
Orlando, Florida, 32819-8031
United States
Local Institution - 0238
Orlando, Florida, 32832
United States
Local Institution - 0210
Port Orange, Florida, 32127-5170
United States
Local Institution - 0204
Sarasota, Florida, 34239-3228
United States
Local Institution - 0012
Stuart, Florida, 34997-5765
United States
Local Institution - 0136
Stuart, Florida, 34997-6405
United States
Local Institution - 0200
Tampa, Florida, 33607-6210
United States
Local Institution - 0080
Tampa, Florida, 33607-6616
United States
Local Institution - 0087
Tampa, Florida, 33609-4049
United States
Local Institution - 0042
Tampa, Florida, 33613-4808
United States
Local Institution - 0194
Viera, Florida, 32940-7948
United States
Local Institution - 0011
Wellington, Florida, 33414-9320
United States
Local Institution - 0223
West Palm Beach, Florida, 33407-3234
United States
Local Institution - 0149
West Palm Beach, Florida, 33409-6611
United States
Local Institution - 0029
Windermere, Florida, 34786-8919
United States
Local Institution - 0101
Winter Park, Florida, 32789-1848
United States
Local Institution - 0154
Winter Park, Florida, 32792
United States
Local Institution - 0105
Columbus, Georgia, 31909-1692
United States
Local Institution - 0236
Chicago, Illinois, 60611-2818
United States
Local Institution - 0021
Chicago, Illinois, 60640-2831
United States
Local Institution - 0161
Elk Grove Village, Illinois, 60007-3362
United States
Local Institution - 0003
Gurnee, Illinois, 60031
United States
Local Institution - 0145
Park Ridge, Illinois, 60068
United States
Local Institution - 0081
Springfield, Illinois, 62702-4968
United States
Local Institution - 0235
Boston, Massachusetts, 02116
United States
Local Institution - 0025
Boston, Massachusetts, 02131-2515
United States
Local Institution - 0015
Braintree, Massachusetts, 02184
United States
Local Institution - 0174
Foxboro, Massachusetts, 02035-1309
United States
Local Institution - 0118
Methuen, Massachusetts, 01844-5864
United States
Local Institution - 0040
Newton, Massachusetts, 02459-3328
United States
Local Institution - 0120
Plymouth, Massachusetts, 02360-7223
United States
Local Institution - 0045
Watertown, Massachusetts, 02472-4153
United States
Local Institution - 0119
Portsmouth, New Hampshire, 03801-6822
United States
Local Institution - 0031
Princeton, New Jersey, 08540-2859
United States
Local Institution - 0062
Toms River, New Jersey, 08755-5043
United States
Local Institution - 0060
Albany, New York, 12208-3464
United States
Local Institution - 0157
Amherst, New York, 14226-1727
United States
Local Institution - 0061
Manhasset, New York, 11030-3816
United States
Local Institution - 0205
New York, New York, 10029-5611
United States
Local Institution - 0214
New York, New York, 10029-5611
United States
Local Institution - 0104
New York, New York, 10029-6504
United States
Local Institution - 0133
New York, New York, 10032-3726
United States
Local Institution - 0043
Matthews, North Carolina, 28105-8336
United States
Local Institution - 0215
Dayton, Ohio, 45459-4296
United States
Local Institution - 0155
Independence, Ohio, 44131
United States
Local Institution - 0023
Plymouth Meeting, Pennsylvania, 19462-7401
United States
Local Institution - 0024
East Providence, Rhode Island, 02914
United States
Local Institution - 0163
Providence, Rhode Island, 02906-4800
United States
Local Institution - 0132
Cordova, Tennessee, 38018-4254
United States
Local Institution - 0140
Franklin, Tennessee, 37067-5922
United States
Local Institution - 0222
Nashville, Tennessee, 37212
United States
Local Institution - 0069
Austin, Texas, 78757-8046
United States
Local Institution - 0033
Beaumont, Texas, 77702
United States
Local Institution - 0051
Dallas, Texas, 75231-4316
United States
Local Institution - 0016
Houston, Texas, 77074-1812
United States
Local Institution - 0196
Fairfax, Virginia, 22031-5216
United States
Local Institution - 0168
Richmond, Virginia, 23294
United States

Collaborators and Investigators

Sponsor: Bristol-Myers Squibb

  • Bristol-Myers Squibb, STUDY_DIRECTOR, Bristol-Myers Squibb

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2024-03-20
Study Completion Date2027-03-18

Study Record Updates

Study Start Date2024-03-20
Study Completion Date2027-03-18

Terms related to this study

Keywords Provided by Researchers

  • Alzheimer Disease
  • BMS-986446
  • Neurodegenerative disease
  • Dementia
  • Brain Diseases
  • Anti-MTBR tau monoclonal antibody
  • TargetTau-1
  • Anti-tau therapy

Additional Relevant MeSH Terms

  • Alzheimer Disease, Early Onset