RECRUITING

Endotypic Stability in CRS

Description

A Case control study with 150 cases and 50 controls will be conducted. Immunologic (cytokines measurements in nasal secretions and sinonasal tissues), histopathologic (tissue eosinophilia) and clinical parameters (Lund-Mackay and Lund-Kennedy score, lung function tests), surveys (SNOT- 22, SF-36 quality of life survey) will be compared between different groups of patients

Study Overview

Study Details

Study overview

A Case control study with 150 cases and 50 controls will be conducted. Immunologic (cytokines measurements in nasal secretions and sinonasal tissues), histopathologic (tissue eosinophilia) and clinical parameters (Lund-Mackay and Lund-Kennedy score, lung function tests), surveys (SNOT- 22, SF-36 quality of life survey) will be compared between different groups of patients

Comparison of Endotypic Stability in Various Populations With Chronic Sinusitis

Endotypic Stability in CRS

Condition
Chronic Sinusitis
Intervention / Treatment

-

Contacts and Locations

Philadelphia

Thomas Jefferson University Department of Otolaryngology, Philadelphia, Pennsylvania, United States, 19107

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Patients with Chronic sinusitis (with or without polyps)
  • * Undergoing endoscopic sinus surgery during the study period
  • * More than 18 years
  • * No chronic illness/ malignancy

Ages Eligible for Study

18 Years to 100 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Thomas Jefferson University,

Study Record Dates

2026-01-31