RECRUITING

Long-Term Follow-up Study for Subjects With CHB Previously Treated With Imdusiran (AB729)

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

This is a long term follow-up study for chronic hepatitis B (CHB) subjects who have received imdusiran treatment in a prior clinical trial, stopped NA therapy during that trial, and remain off therapy. Subjects may enroll after completing the end of study visit (baseline visit within 12 weeks ± 1 week from the end of study \[EOS\] visit) from their imdusiran clinical trial (the "parent study"). No interventions will be performed in this study other than blood sample collections, review of current medications, and reporting of any adverse events related to study procedures or NA therapy if restarted. Study participation will be for approximately 2 years (to complete a total of at least 3 years of follow-up while off NA therapy, inclusive of parent study participation).

Official Title

A Long-Term Follow-up Study for Subjects With Chronic Hepatitis B Previously Treated With Imdusiran (AB-729)

Quick Facts

Study Start:2024-07-11
Study Completion:2029-10-30
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06277037

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:20 Years to 70 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Have participated in a prior imdusiran clinical trial,
  2. * Have discontinued NA therapy in that trial and remain off NA therapy,
  3. * Have completed less than 3 years of follow-up visits after NA discontinuation in the parent study.
  4. * Have the ability to review and provide signed informed consent which includes compliance with all protocol-specified visit schedules and requirements.
  1. * Not applicable

Contacts and Locations

Study Contact

Michael Child
CONTACT
267-332-6213
mchild@arbutusbio.com

Study Locations (Sites)

Research and Education Inc.
San Diego, California, 92105
United States
University of Miami Miller School of Medicine
Miami, Florida, 33136
United States
Infectious Disease Care
Hillsborough, New Jersey, 08844
United States

Collaborators and Investigators

Sponsor: Arbutus Biopharma Corporation

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2024-07-11
Study Completion Date2029-10-30

Study Record Updates

Study Start Date2024-07-11
Study Completion Date2029-10-30

Terms related to this study

Additional Relevant MeSH Terms

  • Long Term Follow-up