RECRUITING

Treatment With Aspirin After Preeclampsia: TAP Trial

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The objective of this research project is to conduct a single-site pilot trial to assess the feasibility and effect of low-dose aspirin to augment vascular recovery in the immediate postpartum period after preeclampsia through two specific aims: 1) to pilot test the feasibility of conducting a randomized controlled trial of postpartum low dose aspirin vs. placebo, and 2) to assess the effect of postpartum aspirin on endothelial function and blood pressure. Our central hypothesis is that postpartum administration of low-dose aspirin following preeclampsia will be feasible, improve endothelial function, and lower BP at 6 months postpartum. Subjects will undergo 3 study visits involving BP measurements, blood draws, questionnaires, and/or microiontophoresis. Up to 60 adult subjects will be enrolled at Magee-Women's Hospital.

Official Title

Treatment With Aspirin After Preeclampsia: TAP Trial

Quick Facts

Study Start:2024-05-29
Study Completion:2026-06-01
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06281665

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 55 Years
Sexes Eligible for Study:FEMALE
Accepts Healthy Volunteers:No
Standard Ages:ADULT
Inclusion CriteriaExclusion Criteria
  1. * Postpartum individuals ≥18 years old
  2. * Preeclampsia diagnosis
  1. * Fetal anomaly
  2. * Multiple gestation
  3. * Pre-pregnancy hypertension
  4. * Allergy or contraindication to low-dose aspirin
  5. * Pre-pregnancy diabetes

Contacts and Locations

Study Contact

Alisse K Hauspurg, MD
CONTACT
412-641-1381
janickia@upmc.edu
Sila Yavan, MS
CONTACT
4124174981
yavans@upmc.edu

Principal Investigator

Alisse K Hauspurg, MD
PRINCIPAL_INVESTIGATOR
UPMC Magee Women's Hospital

Study Locations (Sites)

University of Pittsburgh Magee-Womens Hospital
Pittsburgh, Pennsylvania, 15213
United States

Collaborators and Investigators

Sponsor: Alisse Hauspurg

  • Alisse K Hauspurg, MD, PRINCIPAL_INVESTIGATOR, UPMC Magee Women's Hospital

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2024-05-29
Study Completion Date2026-06-01

Study Record Updates

Study Start Date2024-05-29
Study Completion Date2026-06-01

Terms related to this study

Keywords Provided by Researchers

  • Hypertension

Additional Relevant MeSH Terms

  • Hypertensive Disorder of Pregnancy
  • Pre-Eclampsia
  • Hypertension
  • Eclampsia
  • Gestational Hypertension
  • Cardiovascular Diseases
  • Toxemia
  • Pregnancy Complications
  • Vascular Diseases
  • Hypertension, Pregnancy Induced
  • Hypertension;Pre-Eclamptic