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CHARGE Study: CHoice ARchitecture Genetic tEsting

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Conditions

Hereditary Cancercascade genetic testinghybrid type Ifeasibility

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

CHARGE is a hybrid type I feasibility study to compare a choice architecture intervention for cascade genetic testing to usual care.

Official Title

CHARGE: CHOICE ARCHITECTURE IN GENETIC TESTING

Quick Facts

Study Start:2024-02-16
Study Completion:2025-07-31
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:COMPLETED

Study ID

NCT06284330

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Have a newly reported pathogenic or likely pathogenic variant in one or more of the following genes: APC, ATM, BRCA1, BRCA2, CDH1, CHEK2, PALB2, MLH1, MSH2, MSH6, PMS2, PTEN, TP53
  2. * 18 years of age or older
  3. * English fluency
  4. * Have at least 1 adult living genetically related relative who resides in Texas
  1. * Referred for genetic testing by a relative with a pathogenic variant
  2. * Unwilling to be randomized to a study arm

Contacts and Locations

Principal Investigator

Sukh Makhnoon, PhD, MS
PRINCIPAL_INVESTIGATOR
UT Southwestern Medical Center

Study Locations (Sites)

UT Southwestern Medical Center
Dallas, Texas, 75390
United States

Collaborators and Investigators

Sponsor: University of Texas Southwestern Medical Center

  • Sukh Makhnoon, PhD, MS, PRINCIPAL_INVESTIGATOR, UT Southwestern Medical Center

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2024-02-16
Study Completion Date2025-07-31

Study Record Updates

Study Start Date2024-02-16
Study Completion Date2025-07-31

Terms related to this study

Keywords Provided by Researchers

  • cascade genetic testing
  • hybrid type I
  • feasibility

Additional Relevant MeSH Terms

  • Hereditary Cancer