RECRUITING

Stage II/III Colorectal Cancer Recurrence

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

This study will develop an assay to predict disease recurrence in patients with stage II/III CRC after receiving adjuvant chemotherapy, using genome-wide DNA methylation.

Official Title

Predicting Recurrence-Free Survival in Stage III and High-Risk Stage II Colorectal Cancer After Curative-Intent Treatment

Quick Facts

Study Start:2023-03-15
Study Completion:2025-03-15
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06314958

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Stage II (high-risk) or III colorectal cancer (TNM classification, 8th edition).
  2. * Received standard diagnostic, staging, and therapeutic procedures as per local guidelines
  3. * Received stage-specific curative-intent resection followed by adjuvant chemotherapy.
  4. * Confirmed cancer-free survivorship confirmed at the time of study inclusion.
  1. * Lack of written informed consent.
  2. * Development of recurrence in the first 6 months following adjuvant chemotherapy completion.
  3. * Hereditary colorectal cancer syndromes (identified through genetic testing)
  4. * Inflammatory bowel diseases

Contacts and Locations

Study Contact

Ajay Goel, PhD
CONTACT
6262183452
AJGOEL@COH.ORG

Principal Investigator

Ajay Goel, PhD
PRINCIPAL_INVESTIGATOR
City of Hope Medical Center

Study Locations (Sites)

City of Hope Medical Center
Monrovia, California, 91016
United States

Collaborators and Investigators

Sponsor: City of Hope Medical Center

  • Ajay Goel, PhD, PRINCIPAL_INVESTIGATOR, City of Hope Medical Center

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2023-03-15
Study Completion Date2025-03-15

Study Record Updates

Study Start Date2023-03-15
Study Completion Date2025-03-15

Terms related to this study

Keywords Provided by Researchers

  • Recurrence-free Survival (RFS)
  • Overall Survival (OS)
  • Methylation
  • DNA methylation
  • carcinoembryonic antigen (CEA)

Additional Relevant MeSH Terms

  • Colorectal Cancer
  • Colorectal Adenocarcinoma
  • Colorectal Cancer Stage II
  • Colorectal Cancer Stage III
  • Colorectal Cancer Recurrent