ACTIVE_NOT_RECRUITING

Lung Cancer Risk Assessment and Etiology

Conditions

Quick Navigation

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

This study examines the biological and social determinants that may increase the risk for lung cancer in patients and never-smoking individuals. Biological characteristics of a person can include their genetics and social determinants of a person can include their education, income, and environment, all of which can impact their health. Information collected in this study may help increase early detection of lung cancer.

Official Title

Lung Cancer Risk Assessment &Amp; Etiology

Quick Facts

Study Start:2021-07-02

Study Completion:2029-06-15

Study Type:Not specified

Phase:Not Applicable

Enrollment:Not specified

Status:ACTIVE_NOT_RECRUITING

Study ID

NCT06328621

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years

Sexes Eligible for Study:ALL

Accepts Healthy Volunteers:Yes

Standard Ages:ADULT, OLDER_ADULT

Inclusion Criteria	Exclusion Criteria
* Have had clinical germline genetic testing and/or have consented or expressed a willingness to consent to the City of Hope (COH) General Research Protocol COH IRB # 07047 * Age \>= 18 years * Willing to have about 30 mL of blood (approximately 2 tablespoons) drawn during the aspiration visit * Speak English, Spanish, or Mandarin * Lung cancer patients: meeting at least one of the following criteria: * Be a never-smoker with lung cancer (excludes atypical/typical carcinoid and small cell tumors) * Be diagnosed with lung cancer =\< 50 years of age * Have a germline alteration known/suspected to be associated with elevated lung cancer risk * Have a strong family history of lung cancer (\>= one first, second or third degree relative with never-smoking lung cancer, \>= three first, second or third degree relative with lung cancer in one lineage \[side of the family\], \>= one first, second or third degree relative diagnosed with lung cancer under the age of 50. Patients may also be considered eligible if they meet the family history criteria in part and have a truncated family structure \[e.g., only one first and one second degree relative with lung cancer in a small family\]) * Unaffected patients (i.e., those without a lung cancer diagnosis and other cancer diagnosis for the past 5 years) who are at least 50 years of age or at most age 10 years younger than the first case of lung cancer in the family, meeting at least one of the following criteria: * Have a germline alteration known/suspected to be associated with elevated lung cancer risk * Have a strong family history of lung cancer (\>= one first, second or third degree relative with never-smoking lung cancer, \>= three first, second or third degree relative with lung cancer in one lineage \[side of the family\], \>= one first, second or third degree relative diagnosed with lung cancer under the age of 50. Patients may also be considered eligible if they meet the family history criteria in part and have a truncated family structure \[e.g., only one first and one second degree relative with lung cancer in a small family\]) * Of East Asian descent with any family history of lung cancer * Documented informed consent of the participant	* Unable to provide informed consent * Patients who fall under the unaffected cohort criteria but received chest imaging (except chest x-ray) within the last year

Inclusion Criteria

Exclusion Criteria

* Have had clinical germline genetic testing and/or have consented or expressed a willingness to consent to the City of Hope (COH) General Research Protocol COH IRB # 07047
* Age \>= 18 years
* Willing to have about 30 mL of blood (approximately 2 tablespoons) drawn during the aspiration visit
* Speak English, Spanish, or Mandarin
* Lung cancer patients: meeting at least one of the following criteria:
* Be a never-smoker with lung cancer (excludes atypical/typical carcinoid and small cell tumors)
* Be diagnosed with lung cancer =\< 50 years of age
* Have a germline alteration known/suspected to be associated with elevated lung cancer risk
* Have a strong family history of lung cancer (\>= one first, second or third degree relative with never-smoking lung cancer, \>= three first, second or third degree relative with lung cancer in one lineage \[side of the family\], \>= one first, second or third degree relative diagnosed with lung cancer under the age of 50. Patients may also be considered eligible if they meet the family history criteria in part and have a truncated family structure \[e.g., only one first and one second degree relative with lung cancer in a small family\])
* Unaffected patients (i.e., those without a lung cancer diagnosis and other cancer diagnosis for the past 5 years) who are at least 50 years of age or at most age 10 years younger than the first case of lung cancer in the family, meeting at least one of the following criteria:
* Have a germline alteration known/suspected to be associated with elevated lung cancer risk
* Have a strong family history of lung cancer (\>= one first, second or third degree relative with never-smoking lung cancer, \>= three first, second or third degree relative with lung cancer in one lineage \[side of the family\], \>= one first, second or third degree relative diagnosed with lung cancer under the age of 50. Patients may also be considered eligible if they meet the family history criteria in part and have a truncated family structure \[e.g., only one first and one second degree relative with lung cancer in a small family\])
* Of East Asian descent with any family history of lung cancer
* Documented informed consent of the participant

* Unable to provide informed consent
* Patients who fall under the unaffected cohort criteria but received chest imaging (except chest x-ray) within the last year

Contacts and Locations

Principal Investigator

Stacy W Gray

PRINCIPAL_INVESTIGATOR

City of Hope Medical Center

Study Locations (Sites)

City of Hope Medical Center

Duarte, California, 91010

United States

Collaborators and Investigators

Sponsor: City of Hope Medical Center

Stacy W Gray, PRINCIPAL_INVESTIGATOR, City of Hope Medical Center

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2021-07-02

Study Completion Date2029-06-15

Study Record Updates

Study Start Date2021-07-02

Study Completion Date2029-06-15

Terms related to this study

Additional Relevant MeSH Terms

Lung Carcinoma