RECRUITING

Early Onset Colorectal Cancer Detection

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

Colorectal cancer (CRC) once predominantly affected older individuals, but in recent years has witnessed a progressive increase in incidence among young adults. Once rare, early-onset colorectal cancer (EOCRC, that is, a CRC diagnosed before the age of 50) now constitutes 10-15% of all newly diagnosed CRC cases and it stands as the first cause of cancer-related death in young men and the second for young women. This study aims to detect EOCRC with a non-invasive test, using a blood-based molecular assay based on microRNA (ribonucleic acid)

Official Title

Development and Validation fo an Exosome-Based and Machine Learning Powered Liquid Biopsy for the Detection of Early-Onset Colorectal Cancer

Quick Facts

Study Start:2023-04-15
Study Completion:2025-10-15
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06342401

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 50 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:ADULT
Inclusion CriteriaExclusion Criteria
  1. * Stage I, II, III, IV colorectal cancer (TNM classification, 8th edition) diagnosed before the age of 50 (EOCRC cases)
  2. * Received standard diagnostic and staging procedures as per local guidelines, and at least one sample was drawn before receiving any curative-intent treatment
  3. * Colonoscopy-proven cancer-free status at the time of study inclusion (Non-disease controls)
  1. * Hereditary colorectal cancer syndromes (identified through genetic testing)
  2. * Inflammatory bowel diseases
  3. * Lack of written informed consent

Contacts and Locations

Study Contact

Ajay Goel, PhD
CONTACT
626-218-3452
AJGOEL@COH.ORG

Principal Investigator

Ajay Goel, PhD
PRINCIPAL_INVESTIGATOR
City of Hope Medical Center

Study Locations (Sites)

City of Hope Medical Center
Duarte, California, 91010
United States

Collaborators and Investigators

Sponsor: City of Hope Medical Center

  • Ajay Goel, PhD, PRINCIPAL_INVESTIGATOR, City of Hope Medical Center

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2023-04-15
Study Completion Date2025-10-15

Study Record Updates

Study Start Date2023-04-15
Study Completion Date2025-10-15

Terms related to this study

Keywords Provided by Researchers

  • Early onset
  • Young onset
  • Young adult
  • micro-RNA
  • Rectal cancer
  • Cancer of the young
  • Cancer detection
  • Liquid biopsy

Additional Relevant MeSH Terms

  • Colorectal Cancer
  • Colorectal Neoplasms
  • Colorectal Adenocarcinoma
  • Colorectal Cancer Stage I
  • Colorectal Cancer Stage IV
  • Colorectal Cancer Stage II
  • Colorectal Cancer Stage III
  • Colorectal Neoplasms Malignant