RECRUITING

Exercise Rehabilitation Program in MS Who Use Wheelchairs as a Primary Mobility Device

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

Approximately 50% of people with multiple sclerosis (MS) use a wheelchair within 30 years of the initial diagnosis. Wheelchair use in MS is often associated with fatigue as a consequence of muscle weakness. Indeed, fatigue, a prevalent consequence of MS, often becomes debilitating and exhausts energetic resources when carrying-out tasks of daily life and/or interacting with the community, as these require ambulatory mobility. This experience of excessive fatigue has its roots in muscle weakness and results in reliance on a wheelchair for mobility, and the dependency on a wheelchair may further reduce muscular strength, particularly of the lower extremities. We propose that wheelchair users with MS can increase muscular strength through a personalized exercise rehabilitation, and this in turn will improve ambulatory performance and possibly reduce fatigue. To date, no research has examined the effects of this specific exercise rehabilitation program (GH method) on physical function and other disease-related outcomes in persons with MS who use wheelchairs as a primary mobility device.

Official Title

Randomized Pilot Study Evaluating the Effect of a 6-Month Exercise Rehabilitation Program on Physical and Cognitive Function in Persons With MS Who Use Wheelchairs as a Primary Mobility Device

Quick Facts

Study Start:2024-04-29
Study Completion:2027-07-31
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06410261

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * diagnosis of MS
  2. * age above 18 years
  3. * no relapse within last 30 days
  4. * use of wheelchair for mobility in the community
  5. * ability to walk at least 50 feet (or 65 steps) using an assistive device
  6. * low risk for contraindications of physical activity indicated by no more than a single "yes"
  7. * response on the Physical Activity Readiness Questionnaire (PAR-Q)
  8. * willingness to complete the assessments and undergo randomization
  1. * no diagnosis of MS
  2. * less than 18 years of age
  3. * not relapse-free within the last 30 days
  4. * no use of wheelchair as primary mobility device
  5. * no ability to walk for at least 50 feet (or 65 steps)
  6. * high risk for contraindications based on more than a single "yes" response on the PAR-Q
  7. * not willing to complete the testing procedures and undergo randomization

Contacts and Locations

Study Contact

Enrico Benedetti, MD
CONTACT
312-355-1493
enrico@uic.edu
Ilaria Santi
CONTACT
312-285-9653
isanti@uic.edu

Principal Investigator

Enrico Benedetti, MD
PRINCIPAL_INVESTIGATOR
University of Illinois Chicago

Study Locations (Sites)

University of Illinois at Chicago
Chicago, Illinois, 60612
United States

Collaborators and Investigators

Sponsor: University of Illinois at Chicago

  • Enrico Benedetti, MD, PRINCIPAL_INVESTIGATOR, University of Illinois Chicago

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2024-04-29
Study Completion Date2027-07-31

Study Record Updates

Study Start Date2024-04-29
Study Completion Date2027-07-31

Terms related to this study

Keywords Provided by Researchers

  • Exercise
  • Rehabilitation
  • Physical function
  • Cognition

Additional Relevant MeSH Terms

  • Multiple Sclerosis