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NeuroFLiPP: Parametric PET of Neuroinflammation in Fatty Liver Disease

Description

Alzheimer's Disease and related dementias (ADRD) affect about 6 million people in the U.S. and are the fifth leading cause of death for adults over 65. Recent research is investigating how chronic liver diseases like Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD), which affects one-third of the U.S. population, might influence ADRD through the liver-brain axis. MASLD shares risk factors with Alzheimer's, such as diabetes and hypertension, and studies have linked MASLD to increased risks of cognitive decline and ADRD. Mouse-model studies suggest that chronic liver inflammation in MASLD can induce neuroinflammation and accelerate Alzheimer's pathology, highlighting the importance of studying the liver-brain connection to identify new therapeutic targets for ADRD. The goal of this research is to develop a practical PET imaging method using 18F-FDG to simultaneously assess liver and brain inflammation in patients with MASLD-related ADRD. This approach leverages dynamic FDG-PET scanning and advanced tracer kinetic modeling to quantify glucose transport, overcoming limitations of traditional imaging methods that cannot noninvasively assess chronic liver inflammation. The new method aims to enable comprehensive imaging of liver-brain inflammation crosstalk, validated against the 18F-DPA-714 radiotracer. Success in this project could provide a valuable imaging tool for linking liver inflammation with neuroinflammation and cognitive decline, advancing clinical research and potentially uncovering new pathways for ADRD treatment

Conditions

Positron Emission Tomography
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Positron Emission Tomography

Study Overview

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Study Details

Study overview

Alzheimer's Disease and related dementias (ADRD) affect about 6 million people in the U.S. and are the fifth leading cause of death for adults over 65. Recent research is investigating how chronic liver diseases like Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD), which affects one-third of the U.S. population, might influence ADRD through the liver-brain axis. MASLD shares risk factors with Alzheimer's, such as diabetes and hypertension, and studies have linked MASLD to increased risks of cognitive decline and ADRD. Mouse-model studies suggest that chronic liver inflammation in MASLD can induce neuroinflammation and accelerate Alzheimer's pathology, highlighting the importance of studying the liver-brain connection to identify new therapeutic targets for ADRD. The goal of this research is to develop a practical PET imaging method using 18F-FDG to simultaneously assess liver and brain inflammation in patients with MASLD-related ADRD. This approach leverages dynamic FDG-PET scanning and advanced tracer kinetic modeling to quantify glucose transport, overcoming limitations of traditional imaging methods that cannot noninvasively assess chronic liver inflammation. The new method aims to enable comprehensive imaging of liver-brain inflammation crosstalk, validated against the 18F-DPA-714 radiotracer. Success in this project could provide a valuable imaging tool for linking liver inflammation with neuroinflammation and cognitive decline, advancing clinical research and potentially uncovering new pathways for ADRD treatment

NeuroFLiPP - Parametric PET of Neuroinflammation in Fatty Liver Disease

NeuroFLiPP: Parametric PET of Neuroinflammation in Fatty Liver Disease

Condition
Positron Emission Tomography
Intervention / Treatment

-

Contacts and Locations

Sacramento

UC Davis EXPLORER Molecular Imaging Center, Sacramento, California, United States, 95816

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Participants \>=18 years age
  • * Participants who have or have planned a liver biopsy as:
  • * standard of care for fatty liver disease with risk factors for metabolic dysfunction-associated steatohepatitis (MASH), or
  • * as part of another Clinical Trials study for MASH, or
  • * standard of care prior to undergoing bariatric surgery
  • * Liver biopsy needs to be within 6 months of planned study-related imaging
  • * Ability to provide informed consent.
  • * History of alcohol abuse, chronic hepatitis B or C, or other chronic liver disease other than non-alcoholic fatty liver disease.
  • * Uncontrolled claustrophobia
  • * Body weight \>225 kg due to limitations of the scanner bed
  • * Pregnant or breast-feeding (due to risks of ionizing radiation; urine pregnancy test will be administered prior to start of each PET/CT session for all participants between 18 to 60 years old who are able to get pregnant, unless documented hysterectomy is available)
  • * Concurrent or prior enrollment in a separate research study involving a PET scan performed within the last 12 months for research purposes only.
  • * Prisoners
  • * Any comorbidity that, in the opinion of the investigator, could compromise protocol objectives.
  • * Pre-existing neurodegenerative disorders and dementia
  • * Significant history of major skull concussion or repetitive head trauma
  • * Currently on anticoagulant therapy
  • * Metal implants (e.g., pacemaker) or claustrophobia that would preclude MRI scans

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

University of California, Davis,

Guobao Wang, PhD, PRINCIPAL_INVESTIGATOR, UC Davis Health Department of Radiology

Study Record Dates

2027-07