RECRUITING

Post-CA Neuroprotection With Magnesium

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The purpose of this pilot interventional study is to collect preliminary data on administering magnesium sulfate as a neuroprotective medication in patients who achieved Return of Spontaneous Circulation (ROSC) following Cardiac Arrest (CA). The primary aims are to assess the feasibility and safety of administering magnesium and measure serum markers of neuronal injury at prespecified time points in the post-cardiac arrest period. Because this is a pilot study with a limited sample size, the primary objective is to evaluate the precision and stability of the collected measures to inform the design and formal analysis in a larger trial.

Official Title

Neuroprotection Following Cardiac Arrest: A Randomized Control Trial of Magnesium

Quick Facts

Study Start:2025-03-25
Study Completion:2026-04-01
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06455514

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 85 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Documented post-cardiac arrest patient with Return of Spontaneous Circulation (ROSC) achieved \<2 hours prior to recruitment
  1. * Age \< 18 years or \> 85 years
  2. * Traumatic cardiac arrests
  3. * Unsustained ROSC (\<20 minutes)
  4. * Patient who is responsive/able to follow motor commands within 1 hour of achieving ROSC
  5. * Plan for withdrawal of life support within 72 hours of ROSC
  6. * Known pregnant women at the time of the cardiac arrest
  7. * Known prisoners at the time of the cardiac arrest
  8. * Subjects who have a medical o social condition that would make them inappropriate for the study based on the PI's or clinical team judgement.

Contacts and Locations

Study Contact

Anelly Gonzales
CONTACT
646-501-6923
resuscitationlab@nyulangone.org
Natalia Leontovich
CONTACT
646-501-6923
resuscitationlab@nyulangone.org

Principal Investigator

Sam Parnia
PRINCIPAL_INVESTIGATOR
NYU Langone Health

Study Locations (Sites)

NYU Langone Health
New York, New York, 10016
United States

Collaborators and Investigators

Sponsor: NYU Langone Health

  • Sam Parnia, PRINCIPAL_INVESTIGATOR, NYU Langone Health

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2025-03-25
Study Completion Date2026-04-01

Study Record Updates

Study Start Date2025-03-25
Study Completion Date2026-04-01

Terms related to this study

Additional Relevant MeSH Terms

  • Cardiac Arrest
  • Return of Spontaneous Circulation