COMPLETED

Single and Multiple Ascending Dose Study in Healthy Participants and Participants With an Autoimmune Disease

Conditions

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The main purpose of this study is to to evaluate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD), immunogenicity of LAD191 in healthy adults and in adults with an autoimmune disease.

Official Title

A Phase 1 Randomized, 3-Part, Placebo-Controlled, Single Ascending and Multiple Ascending Dose Study to Assess Safety, Tolerability, Pharmacokinetics, Immunogenicity, and Pharmacodynamics of LAD191 in Healthy Subjects and Subjects With an Autoimmune Disease

Quick Facts

Study Start:2022-07-29

Study Completion:2025-04-03

Study Type:Not specified

Phase:Not Applicable

Enrollment:Not specified

Status:COMPLETED

Study ID

NCT06488209

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 65 Years

Sexes Eligible for Study:ALL

Accepts Healthy Volunteers:Yes

Standard Ages:ADULT, OLDER_ADULT

Inclusion Criteria	Exclusion Criteria
1. Participant provides written informed consent prior to any protocol related procedures, including screening evaluations. Participant must be able to understand the consent form and instructions and to provide consent directly; no guardian/legal representative or caregiver may provide consent for the participant. 2. Male or female, greater than or equal to (\>=)18 and less than or equal to (\<=) 65 years of age, with a body mass index (BMI) within the range of 18.5 to 29.9 kilogram per square meter (kg/m\^2) (inclusive) and body weight of \>=50 kilograms (kg). 3. Participant is healthy, in the clinical judgement of the Investigator, based medical history, physical examination, vital signs, ECG, and laboratory investigations (i.e., has clinical laboratory tests that are within the reference ranges or are clinically acceptable per Investigator judgment). 4. Participant has a seated systolic blood pressure (SBP) \>=90 mm Hg and \<=140 mm Hg or a seated diastolic BP (DBP) \>=50 mm Hg or \<=90 mm Hg. 5. Participant is willing and able to understand and comply with all aspects of the protocol. 6. Participant must agree to the following requirements during the study: * Women of childbearing potential (WOCBP) must have a negative serum pregnancy test result within 7 days prior to first dosing plus a negative urine pregnancy test pre-dose on Day 1 and must be willing to use a highly effective form of contraception (ICH E8 Guideline, 1997; (ICH M3 \[R2\] Guidance, 2009; (FDA M3 \[R2\] Guidance, 2010) for the duration of the study and for at least 3 months after the last dose of study medication. Methods like periodic abstinence, post-ovulation procedures and withdrawal are not considered adequate. * Males with partners of childbearing potential must be willing to use condoms in combination with a second effective method of contraception during the study. Male participants must continue to use contraception (condoms plus a second effective method) for 165 days following administration of the study drug. * Male participants must agree not to donate sperm during the study and for 165 days following administration of the study drug. 1. Male or female, \>=18 to \<=65 years of age, with a BMI within the range 18.5 to 34.9 kg/ m\^2, and body weight of \>=50 kg. 2. Current diagnosis of an autoimmune disease by the Investigator and with signs and symptoms consistent with an autoimmune disease for at least 3 months prior to Day -1 (baseline).	1. Participant has received treatment with LAD191 previously. 2. Known hypersensitivity to LAD191 or any of its excipients. 3. Hypersensitivity or reaction to a prior biologic (antibody-based) therapy (regardless of indication), that was clinically significant, as per judgment of Investigator. 4. History of clinically significant hematological, renal, endocrine, pulmonary, gastrointestinal, cardiovascular, hepatic, psychiatric, neurologic, inflammatory, or allergic disease (including drug allergies, any active seizure disorder requiring therapy with antiepileptic drugs, active peptic ulcer disease, gastrointestinal bleeding, chronic gastritis, inflammatory bowel disease or chronic diarrhea, but excluding mild seasonal allergies or stable, well-controlled thyroiditis). Note that participants with thyroid hormone deficiency, hypertension, hyperlipidemia, or diabetes mellitus may be included in Part 3 of the study. 5. Active chronic or acute infection requiring treatment with systemic antimicrobials, antivirals, antiparasitics, antiprotozoals, or antifungals within 2 weeks before Day -1, or superficial skin infections within 4 weeks prior to Day -1, or fever \> 38°C during within 1 week before Day -1. 6. A positive test for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS CoV-2) on Day -1, or the second negative test after a previous SARS CoV-2 infection was \<=14 days before Day -1, or the participant's SARS CoV-2-associated symptoms resolved \<=14 days before Day -1. 7. Presence of skin comorbidities that may interfere with study assessments, in the opinion of the Investigator. 8. Participant has current tuberculosis (TB) or any history of active or latent TB, regardless of prior treatment. 9. History of malignancy, regardless of outcome. 10. Participant has any condition that, in the opinion of the Investigator, would interfere with the PK evaluation of LAD191 or participant safety or the interpretation of study results 11. Clinically significant ECG abnormality, including, but not limited to, the following: * An abnormal PR interval (\>=220 msec or \<=100 msec). * QTc prolongation (corrected QT interval by Fredericia's formula \[QTcF\] \>=450 msec). * Mean heart rate \<=45 bpm or \>100 bpm. 12. Known history of liver disease or clinically significant abnormal (as per judgment of Investigator) liver function test(s) at Screening (ALT, AST, alkaline phosphatase \[ALP\], or TBili \>1.5 x ULN). 13. Impaired renal function (laboratory values out of the normal range that are clinically significant, as judged by the Investigator). 14. Congenital or acquired immunosuppressive condition that would put participant at risk during the study, per Investigator judgment. 15. Neutropenia; defined as a neutrophil count \<2.0 x 10\^9/L, at Screening. 16. Participant has had major surgery (requiring general anesthesia) within 3 months prior to Day -1, or has major surgery planned during the study. For participants with an autoimmune disease may have had incision and drainage of abscesses up to 1 week before Day -1). 17. Participant has donated plasma or blood or has lost more than 450 ml blood in the 60 days prior to Day -1, or intends to donate blood during the study or in the 60 days after the last scheduled study visit. 18. Participant is pregnant or breastfeeding (or is planning to become pregnant or breastfeed during the study or within 90 days after the last dose of study drug). 19. History of, or positive test result at Screening for, hepatitis B surface antigen (HBsAg), antibody to hepatitis B core antigen (anti-HBcAg), antibody to the hepatitis C virus (anti-HCV), or antibody to the human immunodeficiency virus (HIV-1/2). 20. Participant has taken any medications, including over-the-counter (OTC) medications, within 14 days (or at least 5 half-lives, whichever is longer) before Day -1. (Note that hormonal contraceptives are allowed, and acetaminophen is permitted at doses \<=2 g/day up to 48 hours prior to each study visit). 21. Participant has received any type of live or attenuated vaccinations within 28 days prior to Screening, or is planning to receive any such vaccine during the study (inactive vaccines are allowed) or has received a SARS-CoV-2 vaccine within 14 days of Day 1. 22. Participant has received any investigational drug in any clinical study within 30 days (or at least 5 half-lives, whichever is longer) prior to Day -1, or is on extended follow-up from such a clinical study. 23. Participant has a history (within 2 years prior to Screening) of alcohol or drug abuse, as per Investigator judgment, or has a positive urine screen for drugs of abuse (opiates, cocaine, amphetamines, cannabinoids, barbiturates, benzodiazepines, cotinine, phencyclidine) at Screening or on Day -1, or a positive urine alcohol test at Screening or on Day -1. 24. Consumption of alcohol within 48 hours (2 days) before Day -1. 25. Participant is involved in strenuous physical activity or contact sports within 96 hours (4 days) prior to Day -1. 26. Consumption of any foods containing poppy seeds within 48 hours (2 days) prior to Screening and Day -1 as this could result in a false positive drug screen result. 27. Participant has any other serious or uncontrolled physical or mental dysfunction that, as judged by the Investigator, could place the participant at higher risk derived from his/her participation in the trial, could confound the results of the trial or is likely to prevent the participant from complying with the requirements of the trial or completing the trial. 28. Participant is an employee or relative of the Sponsor/vendors, clinical study site, or is an individual or employee directly involved with the conduct of the study or is an immediate family member of such an individual. * Systemic immunosuppressants/immunomodulators or other systemic treatments for autoimmune disease within 28 days or 5 half-lives (whichever is longer) before Day -1. * Systemic antivirals or antifungals within 28 days prior to Day -1, or systemic antibiotics within 28 days prior to Day -1. * Oral analgesics including opioids within 14 days prior to Day -1, except for acetaminophen at doses of \<=2 g/day for relief of autoimmune disease-associated pain. * Prescription and OTC medications other than those used for the treatment of an autoimmune disease within 14 days or 5 half-lives (whichever is longer) before Day -1, except for hormonal contraceptives, thyroid replacement medications, and medications used for the treatment of hypertension, diabetes mellitus (but not metformin), or hyperlipidemia which are permitted provided the medication(s) and dosage (dose and frequency) have been stable for at least 6 weeks prior to Day -1. Note that participants with thyroid hormone deficiency, hypertension, diabetes mellitus, or hyperlipidemia may be included in Part 3 of the study.

Inclusion Criteria

Exclusion Criteria

1. Participant provides written informed consent prior to any protocol related procedures, including screening evaluations. Participant must be able to understand the consent form and instructions and to provide consent directly; no guardian/legal representative or caregiver may provide consent for the participant.
2. Male or female, greater than or equal to (\>=)18 and less than or equal to (\<=) 65 years of age, with a body mass index (BMI) within the range of 18.5 to 29.9 kilogram per square meter (kg/m\^2) (inclusive) and body weight of \>=50 kilograms (kg).
3. Participant is healthy, in the clinical judgement of the Investigator, based medical history, physical examination, vital signs, ECG, and laboratory investigations (i.e., has clinical laboratory tests that are within the reference ranges or are clinically acceptable per Investigator judgment).
4. Participant has a seated systolic blood pressure (SBP) \>=90 mm Hg and \<=140 mm Hg or a seated diastolic BP (DBP) \>=50 mm Hg or \<=90 mm Hg.
5. Participant is willing and able to understand and comply with all aspects of the protocol.
6. Participant must agree to the following requirements during the study:
* Women of childbearing potential (WOCBP) must have a negative serum pregnancy test result within 7 days prior to first dosing plus a negative urine pregnancy test pre-dose on Day 1 and must be willing to use a highly effective form of contraception (ICH E8 Guideline, 1997; (ICH M3 \[R2\] Guidance, 2009; (FDA M3 \[R2\] Guidance, 2010) for the duration of the study and for at least 3 months after the last dose of study medication. Methods like periodic abstinence, post-ovulation procedures and withdrawal are not considered adequate.
* Males with partners of childbearing potential must be willing to use condoms in combination with a second effective method of contraception during the study. Male participants must continue to use contraception (condoms plus a second effective method) for 165 days following administration of the study drug.
* Male participants must agree not to donate sperm during the study and for 165 days following administration of the study drug.
1. Male or female, \>=18 to \<=65 years of age, with a BMI within the range 18.5 to 34.9 kg/ m\^2, and body weight of \>=50 kg.
2. Current diagnosis of an autoimmune disease by the Investigator and with signs and symptoms consistent with an autoimmune disease for at least 3 months prior to Day -1 (baseline).

1. Participant has received treatment with LAD191 previously.
2. Known hypersensitivity to LAD191 or any of its excipients.
3. Hypersensitivity or reaction to a prior biologic (antibody-based) therapy (regardless of indication), that was clinically significant, as per judgment of Investigator.
4. History of clinically significant hematological, renal, endocrine, pulmonary, gastrointestinal, cardiovascular, hepatic, psychiatric, neurologic, inflammatory, or allergic disease (including drug allergies, any active seizure disorder requiring therapy with antiepileptic drugs, active peptic ulcer disease, gastrointestinal bleeding, chronic gastritis, inflammatory bowel disease or chronic diarrhea, but excluding mild seasonal allergies or stable, well-controlled thyroiditis). Note that participants with thyroid hormone deficiency, hypertension, hyperlipidemia, or diabetes mellitus may be included in Part 3 of the study.
5. Active chronic or acute infection requiring treatment with systemic antimicrobials, antivirals, antiparasitics, antiprotozoals, or antifungals within 2 weeks before Day -1, or superficial skin infections within 4 weeks prior to Day -1, or fever \> 38°C during within 1 week before Day -1.
6. A positive test for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS CoV-2) on Day -1, or the second negative test after a previous SARS CoV-2 infection was \<=14 days before Day -1, or the participant's SARS CoV-2-associated symptoms resolved \<=14 days before Day -1.
7. Presence of skin comorbidities that may interfere with study assessments, in the opinion of the Investigator.
8. Participant has current tuberculosis (TB) or any history of active or latent TB, regardless of prior treatment.
9. History of malignancy, regardless of outcome.
10. Participant has any condition that, in the opinion of the Investigator, would interfere with the PK evaluation of LAD191 or participant safety or the interpretation of study results
11. Clinically significant ECG abnormality, including, but not limited to, the following:
* An abnormal PR interval (\>=220 msec or \<=100 msec).
* QTc prolongation (corrected QT interval by Fredericia's formula \[QTcF\] \>=450 msec).
* Mean heart rate \<=45 bpm or \>100 bpm.
12. Known history of liver disease or clinically significant abnormal (as per judgment of Investigator) liver function test(s) at Screening (ALT, AST, alkaline phosphatase \[ALP\], or TBili \>1.5 x ULN).
13. Impaired renal function (laboratory values out of the normal range that are clinically significant, as judged by the Investigator).
14. Congenital or acquired immunosuppressive condition that would put participant at risk during the study, per Investigator judgment.
15. Neutropenia; defined as a neutrophil count \<2.0 x 10\^9/L, at Screening.
16. Participant has had major surgery (requiring general anesthesia) within 3 months prior to Day -1, or has major surgery planned during the study. For participants with an autoimmune disease may have had incision and drainage of abscesses up to 1 week before Day -1).
17. Participant has donated plasma or blood or has lost more than 450 ml blood in the 60 days prior to Day -1, or intends to donate blood during the study or in the 60 days after the last scheduled study visit.
18. Participant is pregnant or breastfeeding (or is planning to become pregnant or breastfeed during the study or within 90 days after the last dose of study drug).
19. History of, or positive test result at Screening for, hepatitis B surface antigen (HBsAg), antibody to hepatitis B core antigen (anti-HBcAg), antibody to the hepatitis C virus (anti-HCV), or antibody to the human immunodeficiency virus (HIV-1/2).
20. Participant has taken any medications, including over-the-counter (OTC) medications, within 14 days (or at least 5 half-lives, whichever is longer) before Day -1. (Note that hormonal contraceptives are allowed, and acetaminophen is permitted at doses \<=2 g/day up to 48 hours prior to each study visit).
21. Participant has received any type of live or attenuated vaccinations within 28 days prior to Screening, or is planning to receive any such vaccine during the study (inactive vaccines are allowed) or has received a SARS-CoV-2 vaccine within 14 days of Day 1.
22. Participant has received any investigational drug in any clinical study within 30 days (or at least 5 half-lives, whichever is longer) prior to Day -1, or is on extended follow-up from such a clinical study.
23. Participant has a history (within 2 years prior to Screening) of alcohol or drug abuse, as per Investigator judgment, or has a positive urine screen for drugs of abuse (opiates, cocaine, amphetamines, cannabinoids, barbiturates, benzodiazepines, cotinine, phencyclidine) at Screening or on Day -1, or a positive urine alcohol test at Screening or on Day -1.
24. Consumption of alcohol within 48 hours (2 days) before Day -1.
25. Participant is involved in strenuous physical activity or contact sports within 96 hours (4 days) prior to Day -1.
26. Consumption of any foods containing poppy seeds within 48 hours (2 days) prior to Screening and Day -1 as this could result in a false positive drug screen result.
27. Participant has any other serious or uncontrolled physical or mental dysfunction that, as judged by the Investigator, could place the participant at higher risk derived from his/her participation in the trial, could confound the results of the trial or is likely to prevent the participant from complying with the requirements of the trial or completing the trial.
28. Participant is an employee or relative of the Sponsor/vendors, clinical study site, or is an individual or employee directly involved with the conduct of the study or is an immediate family member of such an individual.
* Systemic immunosuppressants/immunomodulators or other systemic treatments for autoimmune disease within 28 days or 5 half-lives (whichever is longer) before Day -1.
* Systemic antivirals or antifungals within 28 days prior to Day -1, or systemic antibiotics within 28 days prior to Day -1.
* Oral analgesics including opioids within 14 days prior to Day -1, except for acetaminophen at doses of \<=2 g/day for relief of autoimmune disease-associated pain.
* Prescription and OTC medications other than those used for the treatment of an autoimmune disease within 14 days or 5 half-lives (whichever is longer) before Day -1, except for hormonal contraceptives, thyroid replacement medications, and medications used for the treatment of hypertension, diabetes mellitus (but not metformin), or hyperlipidemia which are permitted provided the medication(s) and dosage (dose and frequency) have been stable for at least 6 weeks prior to Day -1. Note that participants with thyroid hormone deficiency, hypertension, diabetes mellitus, or hyperlipidemia may be included in Part 3 of the study.

Contacts and Locations

Principal Investigator

Study Director

STUDY_DIRECTOR

Almirall, S.A.

Study Locations (Sites)

Doral Medical Research

Miami, Florida, 33165

United States

Jennifer Parish, MD

Philadelphia, Pennsylvania, 19103

United States

ICON Early Phase Services, LLC

San Antonio, Texas, 78209

United States

Collaborators and Investigators

Sponsor: Almirall, S.A.

Study Director, STUDY_DIRECTOR, Almirall, S.A.

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2022-07-29

Study Completion Date2025-04-03

Study Record Updates

Study Start Date2022-07-29

Study Completion Date2025-04-03

Terms related to this study

Additional Relevant MeSH Terms

Healthy Volunteers
Autoimmune Disease