RECRUITING

A Research Study to Advance the CF Therapeutics Pipeline for People Without Modulators

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Conditions

Cystic Fibrosisineligible and/or not taking CFTR modulatorsPeople with CF

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The REACH study is for people with CF who do not take cystic fibrosis transmembrane conductance regulator (CFTR) modulators. The goal of the REACH study is to collect research data, including health data and specimens, from people with CF who do not take CFTR modulators. This data may be used to inform CF research, help design CF clinical trials and support the development of new treatments for people with CF who do not take CFTR modulators. Another goal of this study is to learn about research involvement for people with CF who do not take CFTR modulators, engage them in research, and give them an opportunity to learn about what is involved in participating in a CF research study.

Official Title

A Research Study to Advance the CF Therapeutics Pipeline for People Without Modulators

Quick Facts

Study Start:2024-09-18
Study Completion:2029-08-14
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06504589

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:12 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:CHILD, ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. Age 18 years or older
  2. Willing and able to provide informed consent
  3. Able to understand and follow study procedures
  4. Stable medical condition
  1. Pregnancy or breastfeeding
  2. Severe psychiatric disorders
  3. Active substance abuse
  4. Unstable medical conditions
  5. Inability to comply with study requirements

Contacts and Locations

Study Contact

Olena Boyarska
CONTACT
206-884-1681
olena.boyarska@seattlechildrens.org
Anna Mead
CONTACT
206-884-7531
anna.mead@seattlechildrens.org

Principal Investigator

Deepika Polineni, MD, MPH
PRINCIPAL_INVESTIGATOR
Washington University School of Medicine
Nicole Mayer-Hamblett, PhD
PRINCIPAL_INVESTIGATOR
Seattle Children's Hospital
Henna Budhwani, PhD, MPH
PRINCIPAL_INVESTIGATOR
Florida State University
Scott Donaldson, MD
PRINCIPAL_INVESTIGATOR
University of North Carolina, Chapel Hill
Felix Ratjen, MD
PRINCIPAL_INVESTIGATOR
University of Toronto

Study Locations (Sites)

The Children's Hospital Alabama, University of Alabama at Birmingham
Birmingham, Alabama, 35233
United States
Phoenix Children's Hospital
Phoenix, Arizona, 85016
United States
Tucson Cystic Fibrosis Center
Tucson, Arizona, 85724
United States
University of Arkansas for Medical Sciences
Little Rock, Arkansas, 72205
United States
University of California San Diego
La Jolla, California, 92093
United States
Childrens Hospital Los Angeles
Los Angeles, California, 90027
United States
Stanford University Medical Center
Palo Alto, California, 94304
United States
University of California, San Francisco - Adult Center
San Francisco, California, 94143
United States
University of California, San Francisco - Peds Center
San Francisco, California, 94158
United States
Children's Hospital Colorado
Aurora, Colorado, 80045
United States
National Jewish Health
Denver, Colorado, 80206
United States
University of Florida
Gainesville, Florida, 32610
United States
University of Miami
Miami, Florida, 33136
United States
Central Florida Pulmonary Group
Orlando, Florida, 32803
United States
Tampa General Hospital
Tampa, Florida, 33606
United States
Children's Healthcare of Atlanta and Emory University
Atlanta, Georgia, 30322
United States
Augusta University
Augusta, Georgia, 30912
United States
Saint Luke's Cystic Fibrosis Center of Idaho
Boise, Idaho, 83702
United States
Northwestern University
Chicago, Illinois, 60611
United States
Riley Hospital for Children
Indianapolis, Indiana, 46202
United States
University of Kansas Medical Center
Kansas City, Kansas, 66160
United States
University of Kentucky
Lexington, Kentucky, 40506
United States
Tulane University
Metairie, Louisiana, 70001
United States
John Hopkins Hospital
Baltimore, Maryland, 21287
United States
Massachusetts General Hospital
Boston, Massachusetts, 02114
United States
Boston Children's Hospital
Boston, Massachusetts, 02115
United States
University of Massachusetts Memorial Health Care
Worcester, Massachusetts, 01655
United States
University of Michigan, Michigan Medicine
Ann Arbor, Michigan, 48109
United States
Wayne State University Harper University Hospital
Detroit, Michigan, 48201
United States
Corewell Health Helen DeVos
Grand Rapids, Michigan, 49503
United States
The Minnesota Cystic Fibrosis Center
Minneapolis, Minnesota, 55455
United States
Washington University School of Medicine
Saint Louis, Missouri, 63110
United States
Billings Clinic
Billings, Montana, 59101
United States
University of Nebraska Medical Center
Omaha, Nebraska, 69198
United States
Morristown Medical Center
Morristown, New Jersey, 07960
United States
The Cystic Fibrosis Center of Western New York
Buffalo, New York, 14203
United States
Cohen Children's Medical Center of New York
Lake Success, New York, 11042
United States
Columbia University Cystic Fibrosis Program
New York, New York, 10032
United States
University of Rochester Medical Center Strong Memorial
Rochester, New York, 14642
United States
New York Medical College at Westchester Medical Center
Valhalla, New York, 10595
United States
University of North Carolina at Chapel Hill
Chapel Hill, North Carolina, 27599
United States
Atrium Health Wake Forest Baptist
Winston-Salem, North Carolina, 27157
United States
University of Cincinnati Medical Center
Cincinnati, Ohio, 45267
United States
Rainbow Babies and Children's Hospital/University Hospitals Cleveland Medical Center
Cleveland, Ohio, 44106
United States
Cleveland Clinic Cystic Fibrosis Program
Cleveland, Ohio, 44195
United States
Nationwide Children's Hospital
Columbus, Ohio, 43205
United States
Dayton Children's Hospital
Dayton, Ohio, 45404
United States
Oregon Health & Sciences University
Portland, Oregon, 97239
United States
Hershey Medical Center Pennsylvania State University
Hershey, Pennsylvania, 17033
United States
Children's Hospital of Philadelphia
Philadelphia, Pennsylvania, 19104
United States
University of Pennsylvania
Philadelphia, Pennsylvania, 19104
United States
University of Pittsburgh Medical Center
Pittsburgh, Pennsylvania, 15224
United States
Medical University of South Carolina
Charleston, South Carolina, 29425
United States
Prisma Health Children's Hospital - Midlands
Columbia, South Carolina, 29203
United States
Vanderbilt University Medical Center
Nashville, Tennessee, 37232
United States
Dell Children's Medical Center of Central Texas
Austin, Texas, 78723
United States
University of Texas Southwestern / Children's Health
Dallas, Texas, 75207
United States
University of Texas Southwestern
Dallas, Texas, 75390
United States
Cook Children's Medical Center
Fort Worth, Texas, 76104
United States
Baylor College of Medicine
Houston, Texas, 77030
United States
Adult Cystic Fibrosis Center at the University of Utah
Salt Lake City, Utah, 84132
United States
Inova L.J. Murphy Pediatric CF Program
Fairfax, Virginia, 22031
United States
Virginia Commonwealth University
Richmond, Virginia, 23219
United States
Seattle Children's Hospital
Seattle, Washington, 98105
United States
University of Washington Medical Center
Seattle, Washington, 98195
United States
Providence Medical Group, Cystic Fibrosis Clinic
Spokane, Washington, 99204
United States
West Virginia University - Morgantown
Morgantown, West Virginia, 26507
United States
University of Wisconsin
Madison, Wisconsin, 53792
United States

Collaborators and Investigators

Sponsor: Nicole Hamblett

  • Deepika Polineni, MD, MPH, PRINCIPAL_INVESTIGATOR, Washington University School of Medicine
  • Nicole Mayer-Hamblett, PhD, PRINCIPAL_INVESTIGATOR, Seattle Children's Hospital
  • Henna Budhwani, PhD, MPH, PRINCIPAL_INVESTIGATOR, Florida State University
  • Scott Donaldson, MD, PRINCIPAL_INVESTIGATOR, University of North Carolina, Chapel Hill
  • Felix Ratjen, MD, PRINCIPAL_INVESTIGATOR, University of Toronto

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2024-09-18
Study Completion Date2029-08-14

Study Record Updates

Study Start Date2024-09-18
Study Completion Date2029-08-14

Terms related to this study

Keywords Provided by Researchers

  • ineligible and/or not taking CFTR modulators
  • People with CF

Additional Relevant MeSH Terms

  • Cystic Fibrosis