RECRUITING

Vaccine Immunity and Inflammation in the Aging Person Living With HIV

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

This study will track immune responsiveness to conjugate pneumococcal vaccines over time to help determine how long protection from this vaccine lasts in individuals with chronic medical conditions (in this study - HIV) and with age.

Official Title

Vaccine Immunity and Inflammation in the Aging Person Living With HIV

Quick Facts

Study Start:2024-07-01

Study Completion:2030-12-14

Study Type:Not specified

Phase:Not Applicable

Enrollment:Not specified

Status:RECRUITING

Study ID

NCT06514547

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 95 Years

Sexes Eligible for Study:ALL

Accepts Healthy Volunteers:Yes

Standard Ages:ADULT, OLDER_ADULT

Inclusion Criteria	Exclusion Criteria
* Age\>=18 years * HIV Diagnosis * On Antiretroviral Therapy with HIV Viral Load\<200 within last year	* Other significant immunosuppressing condition * Age\< 18 years * Pregnancy (at enrollment) * Contraindication to pneumococcal vaccination * Known contraindication to non-clinical blood draws (severe anemia last hemoglobin \<8g/dl) * Subjects who, in the opinion of the Investigator, may be non-adherent to study schedules or procedures. * Adults unable to consent * Individuals with impaired ability to consent * Incarceration at time of enrollment

Inclusion Criteria

Exclusion Criteria

* Age\>=18 years
* HIV Diagnosis
* On Antiretroviral Therapy with HIV Viral Load\<200 within last year

* Other significant immunosuppressing condition
* Age\< 18 years
* Pregnancy (at enrollment)
* Contraindication to pneumococcal vaccination
* Known contraindication to non-clinical blood draws (severe anemia last hemoglobin \<8g/dl)
* Subjects who, in the opinion of the Investigator, may be non-adherent to study schedules or procedures.
* Adults unable to consent
* Individuals with impaired ability to consent
* Incarceration at time of enrollment

Contacts and Locations

Study Contact

Anne Frosch, MD

CONTACT

(612)-283-4349

Anne.Frosch@hcmed.org

Marya Abd El Hadi, BSc

CONTACT

(612)-873-6252

MAbdElHadi@hhrinstitute.org

Study Locations (Sites)

Hennepin Healthcare System

Minneapolis, Minnesota, 55415

United States

Collaborators and Investigators

Sponsor: Hennepin Healthcare Research Institute

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2024-07-01

Study Completion Date2030-12-14

Study Record Updates

Study Start Date2024-07-01

Study Completion Date2030-12-14

Terms related to this study

Additional Relevant MeSH Terms

HIV Infections
Age