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TIDE Project: Biomarker Discovery for Chronic Tinnitus Diagnosis

Description

Research in clinical neuroscience is founded on the conviction that a better understanding of tinnitus related changes of brain function will improve our ability to diagnose and treat tinnitus. Although considerable advances have been made in understanding the mechanisms of tinnitus, the clinical management of tinnitus remains largely based on a 'trial and error' approach. The identification and validation of a biomarker for tinnitus is thought to be the crucial step in the development of a personalized approach to the diagnosis and treatment of tinnitus. The overarching goal of this study is to incorporate advanced technologies to provide an objective, data-driven, personalized approach to the diagnosis of chronic tinnitus. This should lead to a clinically applicable tool that can be widely and easily used.

Conditions

Tinnitus
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Related Conditions:

Tinnitus

Study Overview

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Study Details

Study overview

Research in clinical neuroscience is founded on the conviction that a better understanding of tinnitus related changes of brain function will improve our ability to diagnose and treat tinnitus. Although considerable advances have been made in understanding the mechanisms of tinnitus, the clinical management of tinnitus remains largely based on a 'trial and error' approach. The identification and validation of a biomarker for tinnitus is thought to be the crucial step in the development of a personalized approach to the diagnosis and treatment of tinnitus. The overarching goal of this study is to incorporate advanced technologies to provide an objective, data-driven, personalized approach to the diagnosis of chronic tinnitus. This should lead to a clinically applicable tool that can be widely and easily used.

Identification and Validation of a Biomarker for Tinnitus: an Objective Data-driven Personalized Approach to Diagnosis of Chronic Tinnitus - The Tinnitus Detection (TIDE) Project

TIDE Project: Biomarker Discovery for Chronic Tinnitus Diagnosis

Condition
Tinnitus
Intervention / Treatment

-

Contacts and Locations

Champaign

University of Illinois, Champaign, Illinois, United States, 61820

Austin

University of Texas, Austin, Texas, United States, 78712

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * (2) for controls: never experienced tinnitus
  • * (3) age 18 -70;
  • * (4) ability to understand and consent to the research;
  • * (5) ability to participate (hearing ability);
  • * (6) MoCa Test ≥ 26;
  • * (7) hyperacusis questionnaire score \< 22
  • * (1) objective tinnitus; heartbeat-synchronous tinnitus as primary complaint;
  • * (2) otosclerosis; acoustic neuroma or other relevant ear disorders with fluctuating hearing;
  • * (3) acute ear nose and throat infections (acute otitis media, otitis externa, acute sinusitis);
  • * (4) Meniere's disease or similar syndromes;
  • * (5) vestibular migraine;
  • * (6) serious internal, neurological or psychiatric conditions;
  • * (7) epilepsy or other CNS disorders (brain tumor, encephalitis);
  • * (8) clinically relevant drug, medication or alcohol abuse up to 12 weeks before study start;
  • * (9) severe hearing loss - inability to communicate properly in the course of the study;
  • * (10) one deaf ear;

Ages Eligible for Study

18 Years to 70 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

University of Regensburg,

Sven Vanneste, Prof., PRINCIPAL_INVESTIGATOR, Trinnitus College Dublin

Study Record Dates

2025-12-31