RECRUITING

Outcomes of High-risk Non-muscle Invasive Bladder Cancer Treated With Blue Light Resection

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

Comparing white-light cystoscopy (WLC) and blue-light cystoscopy (BLC) in TURBT for high risk (HR) non-muscle invasive bladder cancer (NMIBC) patients is crucial to determine the most effective method for reducing residual disease burden and improving recurrence-free survival. Enhanced visualization with BLC may lead to more accurate resections, potentially decreasing recurrence rates and improving long-term outcomes for bladder cancer patients. Patients will be randomized to either WLC TURBT or BLC TURBT, and outcomes will be measured using standard-of-care testing with cystoscopy and cytology, along with minimal residual disease (MRD) burden evaluation using urine next-generation sequencing.

Official Title

Outcomes of High-risk Non-muscle Invasive Bladder Cancer Treated With Blue Light Resection

Quick Facts

Study Start:2024-12-20
Study Completion:2028-01-04
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06525571

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Patients undergoing TURBT for radiographic or cystoscopic positive tumor
  2. * 18+ years old
  3. * Upper tract evaluated using standard of care throughout duration of the study
  4. * Induction intravesical therapy initiated within four weeks of TURBT
  1. * Variant histology consisting of less than 50% urothelial carcinoma
  2. * History, or current diagnosis, of upper tract tumor or muscle-invasive bladder cancer
  3. * Prior history of pelvic radiation
  4. * Active urinary tract infection (UTI)
  5. * Patients who are noncompliant with the study protocol

Contacts and Locations

Study Contact

Riziki Covington
CONTACT
2026605561
rcoving5@jh.edu
Armine Smith, MD
CONTACT
2026605561
asmit165@jhmi.edu

Principal Investigator

Armine Smith, MD
PRINCIPAL_INVESTIGATOR
Sibley Memorial Hospital

Study Locations (Sites)

Sibley Memorial Hospital
Washington, District of Columbia, 20016
United States
Johns Hopkins University School of Medicine
Baltimore, Maryland, 21287
United States

Collaborators and Investigators

Sponsor: Johns Hopkins University

  • Armine Smith, MD, PRINCIPAL_INVESTIGATOR, Sibley Memorial Hospital

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2024-12-20
Study Completion Date2028-01-04

Study Record Updates

Study Start Date2024-12-20
Study Completion Date2028-01-04

Terms related to this study

Keywords Provided by Researchers

  • Blue light cystoscopy
  • Cysview

Additional Relevant MeSH Terms

  • Bladder Cancer