RECRUITING

Study to Assess the Use of Tezampanel for Opioid Withdrawal Syndrome in Treatment-Seeking Patients With Opioid Use Disorder

Conditions

Opioid Use Disorder opioid OUD opioid withdrawal syndrome

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

This study is examining the use of Tezampanel (TZP) for treatment of Opioid Withdrawal Syndrome (OWS) in participants with Opioid Use Disorder (OUD). Participants will receive TZP or placebo (PBO) daily on Days 2 - 7 during a 7-day inpatient stay at the research center to determine safety, pharmacokinetic (PK) assessment, and efficacy of TZP for OWS.

Official Title

A Phase I, Single-Center, Single-Blind, Placebo-Controlled, Dose-Escalation Study to Assess the Safety, Pharmacokinetics and Efficacy of Tezampanel for Opioid Withdrawal Syndrome in Treatment-Seeking Patients With Opioid Use Disorder

Quick Facts

Study Start:2024-10-16

Study Completion:2025-11-30

Study Type:Not specified

Phase:Not Applicable

Enrollment:Not specified

Status:RECRUITING

Study ID

NCT06538558

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 65 Years

Sexes Eligible for Study:ALL

Accepts Healthy Volunteers:No

Standard Ages:ADULT, OLDER_ADULT

Inclusion Criteria	Exclusion Criteria
1. Male, female or non-binary, age 18 to 65 years of age at Screening. 2. Diagnosis of Opioid Use Disorder (OUD) 3. Positive Urine Drug Screen (UDS) for opioid(s) at the Screening and Baseline Visits. 4. Recent active/chronic use of short-acting illicit and/or prescribed opioids and/or long-acting Opioid Use Disorder (OUD) maintenance treatments buprenorphine or methadone at the Screening and Baseline Visits. 5. Already engaged and fully assessed in a longitudinal-outpatient treatment program that provides opioid addiction treatment encompassing the full spectrum of opioid maintenance and abstinence (injectable Vivitrol®) treatments, in which the host clinic is prepared and equipped to continue with: 1. maintenance treatment (methadone or buprenorphine treatment) for study non-completers, or 2. long-acting injectable naltrexone treatment (Vivitrol®), for completers with next dose delivered approximately 30 days after Study Day 6. 6. Post-menopausal/sterile or agree to use chemical or barrier methods of birth control from time of informed consent through 30 days post last treatment. 7. Stable concomitant medications. 8. Stable concomitant medications for depression, post-traumatic stress disorder, psychotic disorders, and bipolar spectrum disorders if one of the following: SSRI, SNRI, bupropion, MAOI, trazodone, Tricyclic, typical and atypical antipsychotics, lithium, antihistamine, alpha-adrenergic agent, nicotine replacement. 9. Stable concomitant medications: propranolol, prazosin, and clonidine if used for psychiatric reasons, and not to control hypertension at the Baseline Visit and unchanged on Study Day 1. 10. Provide informed consent. 11. Understand and follow Lifestyle Considerations per protocol.	1. Clinically at risk or unstable due to: 1. Active psychosis or mania that is impairing insight, decision-making, perception, or ability to provide informed consent as assessed by the PI or designee during the Screening or Baseline Visits, discussion with the outpatient treatment provider, or at Study Day 1. 2. Active suicidal ideation or intent as assessed by the PI or designee during the Baseline Visit interview or the C-SSRS on Study Day 1. 3. Chronic benzodiazepine use, or at significant risk for, or in a state of benzodiazepine withdrawal at the Screening or Baseline Visits, Study Day 1, or in discussion with the outpatient treatment provider. 4. Alcohol Use Disorder as assessed by the PI or designee with \> 14 drinks / week (average of \> 2 / day) at the Screening or Baseline Visits or Study Day 1 or in discussion with the outpatient treatment provider. 5. Seizure disorder; use of anti-convulsant for bipolar disorder, seizure, or chronic pain (including topiramate, gabapentin, carbamazepine, valproic acid) at the Screening or Baseline Visits or Study Day 1. 6. Cardiac abnormalities including arrythmia, conduction abnormality or baseline QTC prolongation (QTcF \> 450 males; 470 females); pacemaker, history of myocardial infarction at the Baseline Visit. 7. Hypertension, diabetes mellitus, cancer, liver, and/or kidney disease and associated medications at the Screening or Baseline Visits or at Study Day 1. 2. Abnormal safety laboratory results. 3. ALT or AST \> 3xs upper limit of normal at Baseline or Study Day 1. 4. Undiagnosed hypertension defined as: 1. Baseline Visit: BP \> 160 / 100 mmHg or heart rate \> 120 bpm 2. Study Day 1: BP ≥ 180 / 120 mmHg or heart rate ≥ 140 bpm that continues after 10 minutes of rest. 5. Temperature \> 38.1°C at the Baseline Visit. Temperature \> 38.9°C at the Study Day 1. 6. Medications that stimulate the dopamine system pre- or post-synaptically, including L-Dopa, lisdexamfetamine, modafinil, gabapentin, phenobarbital, etc.) at the Screening or Baseline Visits or Study Day 1. 7. Medications for addiction, ADHD, insomnia, or bipolar spectrum disorders involving dopamine system stimulants, benzodiazepines, barbiturates, or mood stabilizers active via GABA or glutamate receptor system (e.g. valproic acid, lamotrigine, carbamazepine, acamprosate, disulfiram) at the Screening or Baseline Visits or Study Day 1. 8. Use of naltrexone or acamprosate (active at opioid or glutamatergic receptors) at the Screening or Baseline Visits or Study Day 1. 9. Significant, active infection (e.g., positive for syphilis, tuberculosis, COVID-19, HBV) at the Baseline Visit. 10. Symptomatic HIV or HCV (detectable viral load) at the Baseline Visit. 11. Pregnancy or breastfeeding at the Screening or Baseline Visits or Study Day 1. 12. Poor venous access at the Baseline Visit or Study Day 1. 13. Participation in a research study involving another investigational drug in the last 3 months at the Screening Visit.

Inclusion Criteria

Exclusion Criteria

1. Male, female or non-binary, age 18 to 65 years of age at Screening.
2. Diagnosis of Opioid Use Disorder (OUD)
3. Positive Urine Drug Screen (UDS) for opioid(s) at the Screening and Baseline Visits.
4. Recent active/chronic use of short-acting illicit and/or prescribed opioids and/or long-acting Opioid Use Disorder (OUD) maintenance treatments buprenorphine or methadone at the Screening and Baseline Visits.
5. Already engaged and fully assessed in a longitudinal-outpatient treatment program that provides opioid addiction treatment encompassing the full spectrum of opioid maintenance and abstinence (injectable Vivitrol®) treatments, in which the host clinic is prepared and equipped to continue with:
1. maintenance treatment (methadone or buprenorphine treatment) for study non-completers, or
2. long-acting injectable naltrexone treatment (Vivitrol®), for completers with next dose delivered approximately 30 days after Study Day 6.
6. Post-menopausal/sterile or agree to use chemical or barrier methods of birth control from time of informed consent through 30 days post last treatment.
7. Stable concomitant medications.
8. Stable concomitant medications for depression, post-traumatic stress disorder, psychotic disorders, and bipolar spectrum disorders if one of the following: SSRI, SNRI, bupropion, MAOI, trazodone, Tricyclic, typical and atypical antipsychotics, lithium, antihistamine, alpha-adrenergic agent, nicotine replacement.
9. Stable concomitant medications: propranolol, prazosin, and clonidine if used for psychiatric reasons, and not to control hypertension at the Baseline Visit and unchanged on Study Day 1.
10. Provide informed consent.
11. Understand and follow Lifestyle Considerations per protocol.

1. Clinically at risk or unstable due to:
1. Active psychosis or mania that is impairing insight, decision-making, perception, or ability to provide informed consent as assessed by the PI or designee during the Screening or Baseline Visits, discussion with the outpatient treatment provider, or at Study Day 1.
2. Active suicidal ideation or intent as assessed by the PI or designee during the Baseline Visit interview or the C-SSRS on Study Day 1.
3. Chronic benzodiazepine use, or at significant risk for, or in a state of benzodiazepine withdrawal at the Screening or Baseline Visits, Study Day 1, or in discussion with the outpatient treatment provider.
4. Alcohol Use Disorder as assessed by the PI or designee with \> 14 drinks / week (average of \> 2 / day) at the Screening or Baseline Visits or Study Day 1 or in discussion with the outpatient treatment provider.
5. Seizure disorder; use of anti-convulsant for bipolar disorder, seizure, or chronic pain (including topiramate, gabapentin, carbamazepine, valproic acid) at the Screening or Baseline Visits or Study Day 1.
6. Cardiac abnormalities including arrythmia, conduction abnormality or baseline QTC prolongation (QTcF \> 450 males; 470 females); pacemaker, history of myocardial infarction at the Baseline Visit.
7. Hypertension, diabetes mellitus, cancer, liver, and/or kidney disease and associated medications at the Screening or Baseline Visits or at Study Day 1.
2. Abnormal safety laboratory results.
3. ALT or AST \> 3xs upper limit of normal at Baseline or Study Day 1.
4. Undiagnosed hypertension defined as:
1. Baseline Visit: BP \> 160 / 100 mmHg or heart rate \> 120 bpm
2. Study Day 1: BP ≥ 180 / 120 mmHg or heart rate ≥ 140 bpm that continues after 10 minutes of rest.
5. Temperature \> 38.1°C at the Baseline Visit. Temperature \> 38.9°C at the Study Day 1.
6. Medications that stimulate the dopamine system pre- or post-synaptically, including L-Dopa, lisdexamfetamine, modafinil, gabapentin, phenobarbital, etc.) at the Screening or Baseline Visits or Study Day 1.
7. Medications for addiction, ADHD, insomnia, or bipolar spectrum disorders involving dopamine system stimulants, benzodiazepines, barbiturates, or mood stabilizers active via GABA or glutamate receptor system (e.g. valproic acid, lamotrigine, carbamazepine, acamprosate, disulfiram) at the Screening or Baseline Visits or Study Day 1.
8. Use of naltrexone or acamprosate (active at opioid or glutamatergic receptors) at the Screening or Baseline Visits or Study Day 1.
9. Significant, active infection (e.g., positive for syphilis, tuberculosis, COVID-19, HBV) at the Baseline Visit.
10. Symptomatic HIV or HCV (detectable viral load) at the Baseline Visit.
11. Pregnancy or breastfeeding at the Screening or Baseline Visits or Study Day 1.
12. Poor venous access at the Baseline Visit or Study Day 1.
13. Participation in a research study involving another investigational drug in the last 3 months at the Screening Visit.

Contacts and Locations

Study Contact

Christopher Toombs

CONTACT

206-957-7321

ctoombs@proniras.com

Study Locations (Sites)

Indiana University School of Medicine

Indianapolis, Indiana, 46202

United States

Collaborators and Investigators

Sponsor: Proniras Corporation

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2024-10-16

Study Completion Date2025-11-30

Study Record Updates

Study Start Date2024-10-16

Study Completion Date2025-11-30

Terms related to this study

Keywords Provided by Researchers

opioid
OUD
opioid withdrawal syndrome

Additional Relevant MeSH Terms

Opioid Use Disorder