RECRUITING

Study to Understand Novel Biomarkers in Researching Dementia

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The purpose of this study is to determine the relationships between amyloid, tau, and neurodegeneration biomarkers in the blood and the presence of Alzheimer's disease (AD) pathology, clinical cognitive decline, and diagnosis. We aim to understand how well blood-based biomarkers can diagnose and predict Alzheimer's disease, which will help to further develop and validate blood tests for the disease.

Official Title

Blood Amyloid, Tau, and Neurodegeneration Biomarkers and Prediction of Clinical Onset, Cognitive Decline, and Dementia Diagnosis

Quick Facts

Study Start:2024-08-14
Study Completion:2028-12
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06547099

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:60 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * At least 60 years of age
  2. * 80% of the newly enrolled clinic-based cohort will have symptoms of forgetfulness, mild cognitive impairment, mild dementia, or Alzheimer's disease as determined by their medical chart and/or provider
  3. * All SEABIRD participants will be invited to participate regardless of their cognitive status
  1. * Unable to perform one or more basic activities of daily living (eating, bathing, dressing, ambulating, toileting) due to cognitive impairment
  2. * Uncontrolled hepatitis B, hepatitis C, or HIV at time of blood collection
  3. * Taking a disease-modifying drug for AD at time of enrollment
  4. * Blood transfusion in the last three months
  5. * Unwilling or unable to participate in all study activities

Contacts and Locations

Study Contact

Lisa Soke
CONTACT
314-747-4857
sunbirdstudy@wustl.edu

Principal Investigator

Randall Bateman, MD
PRINCIPAL_INVESTIGATOR
Washington University School of Medicine
David Carr, MD
STUDY_DIRECTOR
Washington University School of Medicine

Study Locations (Sites)

Washington University School of Medicine
Saint Louis, Missouri, 63110
United States

Collaborators and Investigators

Sponsor: Washington University School of Medicine

  • Randall Bateman, MD, PRINCIPAL_INVESTIGATOR, Washington University School of Medicine
  • David Carr, MD, STUDY_DIRECTOR, Washington University School of Medicine

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2024-08-14
Study Completion Date2028-12

Study Record Updates

Study Start Date2024-08-14
Study Completion Date2028-12

Terms related to this study

Additional Relevant MeSH Terms

  • Alzheimer Disease
  • Mild Cognitive Impairment
  • Dementia