Pharmacokinetics of Butyrate Tablet BKR-017

Eligibility Criteria

• * Men and women, ages 18-70 inclusive
• * Subjects currently on statin treatments.
• * Presence of cirrhosis, or other causes of liver disease
• * Substantial alcohol consumption (\>20 g/day for women or \>30 g/day for men)
• * History of bariatric or intestinal surgery
• * Active gastrointestinal disease including but not limited to irritable bowel syndrome, inflammatory bowel disease (e.g., Crohn's disease and ulcerative colitis), diverticulitis, gastroparesis.
• * Active and clinically significant pancreatic disease, or renal disease as determined by the investigator.
• * History of heart disease that in the opinion of the investigator should exclude the subject from the study.
• * Untreated or uncontrolled hyperthyroidism or hypothyroidism, or other significant thyroid disease
• * Active significant infection as determined by the investigator.
• * Known allergy to butyrate or any of the components of the tablets.
• * Participation in a clinical trial and/or Dosing with an investigational drug during the 30 days before screening, or within 5 half-lives of receipt of an investigational drug or twice the duration of the biological effect of any investigational drug (whichever is longer)
• * Pregnant, nursing, or trying to become pregnant.
• * In the investigator's judgment, the subject is not suitable for the study for any other reason or cannot commit to the requirements of the study.
• * Taking part in another clinical trial or being in the exclusion period of a previous clinical trial.